Exposure characteristics of phthalate metabolites among the Zunyi cohort of pregnant women in Southwest China

Liao, Juan; Fang, Derong; Liu, Yijun; Xiong, Shimin; Wang, Xia; Tian, Yingkuan; Zhang, Haonan; An, Senyou; He, Caidie; Chen, Wei; Liu, Xiang; Wu, Nian; Tian, Kunming; Wang, Linglu; Zhang, Ya; Yuan, Hongyu; Zhang, Li; Li, Quan; Shen, Xubo; Zhou, Yuanzhong

doi:10.1007/s11356-022-19990-6

Cited by 8 publications

(8 citation statements)

References 52 publications

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“…Previous studies have shown that general population who individually or jointly expose to phthalates might add the risk of rising serum uric acid, urinary albumin creatinine ratio (UACR) and microalbumin (Tsai et al, 2022;Tan et al, 2022;. The suppose that pregnant women in southwest China were frequently exposed to phthalates has been proven by the high detection frequency of phthalate metabolites (Liao et al, 2022). And the detectable rates of the ten phthalate metabolites ranges from 61.7 to 100% in our research population.…”

Section: Discussionmentioning

confidence: 63%

“…Although pregnant women in southwest China are widely exposed to phthalates (Liao et al, 2022), no previous research has clari ed whether there is a correlation between maternal serum uric acid levels and the environmental toxins. The results showed that higher MBP, MOP and MBZP were associated with an increase in SUA among pregnant women during the third trimester.…”

Section: Discussionmentioning

confidence: 99%

“…The aim of Zunyi Birth Cohort is to evaluate the impact of environmental factors on pregnant women and fetuses. The detailed information about ZBC has been illustrated in previous articles (Liao et al, 2022). After excluding the population lack of basic data on uric acid, creatinine, phthalate metabolites, covariance information and chronic kidney disease, 851 participants were selected in the further analysis.…”

Section: Study Populationmentioning

confidence: 99%

“…The urine of pregnant women was collected and stored at -80 ℃ before the environmental pollutants were measured. The details of the speci c analysis process have been described in the previous article (Liao et al, 2022).…”

Section: Measurement Of Phthalate Metabolitesmentioning

confidence: 99%

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Association between Urinary Phthalate Metabolites and Serum Uric Acid in the Third Trimester of Pregnant Women

Hong,

Pu,

et al. 2023

Preprint

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Background Phthalates exposure associates with increased serum uric acid levels in the general population, and whether this association also exists in pregnant women has not been explored yet. Methods we conducted a cross-sectional population-based study including 851 pregnant women from a ZunYi birth cohort in southwestern China. Multiple linear regression models were used to explore single relationship between ten urinary phthalate metabolites with SUA and eGFR. Moreover, the overall relationship of ten urinary phthalate metabolites with SUA and eGFR were determined by principal component analysis (PCA) and quantitative g-computation (Q-g) analysis, respectively. Besides, the potential effect modification factors were explored by employing the subgroup analysis. Results The multivariable linear regression showed that MBP, MOP and MBzP were positively associated with SUA, while MEHP and MEHHP were associated with increased eGFR level. Moreover, mixed phthalate metabolites were positively associated with SUA, evidence by PCA analysis, of which MOP, MBzP and MEHP exhibited the major contributors. Furthermore, Q-g regression showed each quantile increase in mixture of phthalate was associated with 3.27% higher SUA (95% CI: 0.21%, 6.41%), but not significant with eGFR. Conclusion pregnant women’s exposure to phthalates was associated with a higher serum uric acid, in which MBP, MBzP and MOP might play important roles. Our results imply that positive perinatal health should be seriously taken to counteract the environment-associated impaired kidney function.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Study Populationmentioning

confidence: 99%

Section: Measurement Of Phthalate Metabolitesmentioning

confidence: 99%

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Association between Urinary Phthalate Metabolites and Serum Uric Acid in the Third Trimester of Pregnant Women

Hong,

Pu,

et al. 2023

Preprint

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“…It has high sensitivity, strong qualitative and quantitative capability, stable and durable performance, the ability to detect large batches, short detection time and simple operation for the analysis of detection data. In this work, we develop a protocol based on GC-MS-MS for the detection of PAHs and PAEs in bulk, as well as a robust method for the pretreatment of urine, which has been used with satisfactory results in several publications [ 30 , 31 , 32 , 33 ]. However, matrix effects affecting the detection of PAHs and PAEs in the placenta are more complex, with a greater variety of chemicals in placental tissues (e.g., clotting factors, hormones, enzymes and amino acids) and lower concentrations of PAHs and PAEs, as well as, more importantly, the fact that solid-state processing is more complex and difficult than liquid processing (solid–liquid conversion requires special treatments such as rapid freezing, grinding, etc.…”

Section: Introductionmentioning

confidence: 99%

Determination of Polycyclic Aromatic Hydrocarbons (PAHs) and Phthalates in Human Placenta by Mixed Hexane/Ether Extraction and Gas Chromatography–Mass Spectrometry/Mass Spectrometry (GC-MS/MS)

Tao,

Tian,

Liao

et al. 2023

Metabolites

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In this study, we evaluated the extraction effect of three different extractants, namely hexane + ether (v/v = 3:1), acetonitrile and ethyl acetate, on polycyclic aromatic hydrocarbons (PAHs) and phthalic acid esters (PAEs) in placenta detected and analysed by triple quadrupole gas chromatography–mass spectrometry (GC-MS/MS). The results showed that n-hexane + ether (v/v = 3:1) had the highest extraction efficiency. Under the optimal conditions, the limits of detection (LOD) for the 10 PAHs were 0.003–0.0167 μg/L with relative standard deviations (RSD) of 1.4–5.48% and detection rates of 68.19–107.05%, and the correlation coefficients were (R2, 0.9982–0.9999). The LODs for the nine PAEs were 0.0015–3.5714 μg/L and the correlation coefficients were (R2, 0.9982–0.9999). The limits of detection (S/N = 3) for the nine PAHs were 0.0015–0.5714 μg/L with relative standard deviations (RSD) of 3.15–8.37%, and the detection rates were 80.45–112.59% with correlations of (R2, 0.9972–0.9998). The method was applied to the analysis of PAHs and phthalates in placenta samples from pregnant women. The method’s accuracy and applicability were demonstrated. In comparison with other methods for the detection of PAEs and PAHs, the method proposed in this paper has a wider linear range, lower minimum detection limit and comparable recovery with good correlation. This paper is dedicated to providing another method for improving the performance of extracting solid tissues.

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Risk assessment and environmental determinants of urinary phthalate metabolites in pregnant women in Southwest China

Lin

Tian

et al. 2023

Environ Sci Pollut Res

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Exposure characteristics of phthalate metabolites among the Zunyi cohort of pregnant women in Southwest China

Cited by 8 publications

References 52 publications

Association between Urinary Phthalate Metabolites and Serum Uric Acid in the Third Trimester of Pregnant Women

Association between Urinary Phthalate Metabolites and Serum Uric Acid in the Third Trimester of Pregnant Women

Determination of Polycyclic Aromatic Hydrocarbons (PAHs) and Phthalates in Human Placenta by Mixed Hexane/Ether Extraction and Gas Chromatography–Mass Spectrometry/Mass Spectrometry (GC-MS/MS)

Risk assessment and environmental determinants of urinary phthalate metabolites in pregnant women in Southwest China

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