Exposure During Pregnancy to Glycol Ethers and Chlorinated Solvents and the Risk of Congenital Malformations

Cordier, Sylvaine; Garlantézec, Ronan; Labat, Laurence; Rouget, Florence; Monfort, Christine; Bonvallot, Nathalie; Roig, Benoît; Pulkkinen, Juha; Chevrier, Cécile; Multigner, Luc

doi:10.1097/ede.0b013e31826c2bd8

Cited by 47 publications

(32 citation statements)

References 27 publications

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“…The common limiting factor of previous population-based epidemiological studies of the association between maternal occupational exposure to solvents and FGR, including our study, is exposure misclassification inherent in indirect, retrospective exposure assessment. In the future, studies with improved exposure assessment, such as studies that could directly assess exposure using biomarkers in prospectively collected biological samples during pregnancy,42 should add a unique contribution to our understanding of the potential effects of solvent exposure during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Assessed occupational exposure to chlorinated, aromatic and Stoddard solvents during pregnancy and risk of fetal growth restriction

et al. 2015

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Objectives Previous experimental and epidemiological research suggests that maternal exposure to some organic solvents during pregnancy may increase the risk of fetal growth restriction (FGR). We evaluated the association between expert-assessed occupational solvent exposure and risk of small for gestational age (SGA) infants in a population-based sample of women in the National Birth Defects Prevention Study. Methods We analysed data from 2886 mothers and their infants born between 1997 and 2002. Job histories were self-reported. Probability of exposure to six chlorinated, three aromatic and one petroleum solvent was assessed by industrial hygienists. SGA was defined as birthweight<10th centile of birthweight-by-gestational age in a national reference. Logistic regression was used to estimate ORs and 95% CIs to assess the association between SGA and exposure to any solvent(s) or specific solvent classes, adjusting for maternal age and education. Results Approximately 8% of infants were SGA. Exposure prevalence to any solvent was 10% and 8% among mothers of SGA and non-SGA infants, respectively. Among women with ≥50% probability of exposure, we observed elevated but imprecise associations between SGA and exposure to any solvent(s) (1.71; 0.86 to 3.40), chlorinated solvents (1.70; 0.69 to 4.01) and aromatic solvents (1.87; 0.78 to 4.50). Conclusions This is the first population-based study in the USA to investigate the potential association between FGR and assessed maternal occupational exposure to distinct classes of organic solvents during pregnancy. The potential associations observed between SGA and exposure to chlorinated and aromatic solvents are based on small numbers and merit further investigation.

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Section: Discussionmentioning

confidence: 99%

Assessed occupational exposure to chlorinated, aromatic and Stoddard solvents during pregnancy and risk of fetal growth restriction

et al. 2015

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“…They all reported higher risks of male genital anomalies associated with maternal solvent exposure, although this risk was statistically significant in only one study 7. Most published studies have not focused on specific chemical classes of solvents and all except one9 used indirect exposure assessment methods.…”

Section: Introductionmentioning

confidence: 99%

“…Only one previous prospective study has used alkoxy acid metabolites as a specific urinary biomarker to evaluate associations between prenatal exposure to GE and the risk of male genital anomalies9: it showed higher risk of male genital anomalies with exposure to some GE metabolites but the associations did not reach statistical significance. Due to its small sample size, however, it had limited statistical power and did not allow us to study subtypes of genital anomalies (ie, cryptorchidism and hypospadias), despite known difference in the mechanisms of these two anomalies.…”

Section: Introductionmentioning

confidence: 99%

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Prenatal exposure to glycol ethers and cryptorchidism and hypospadias: a nested case–control study

et al. 2017

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“…The most common risk factors reported were maternal exposure to tobacco products [81,82], alcohols [83], some viral infections [70], pesticides [84], and teratogens in the workplace or at home in early pregnancy [85][86][87]. Recognized teratogens included rare exposures such as phenytoin, valproic acid, thalidomide, and herbicides such as dioxin.…”

Section: Maternal Exogenous Exposuresmentioning

confidence: 99%

8 Epidemiology of Cleft Lip and Palate

Losee¹,

Kirschner²

2016

Comprehensive Cleft Care, Volume 1

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Orofacial cleft (OFC) anomalies are amongst the most common congenital anomalies and the most common craniofacial anomalies. Despite their poorly characterized etiologies, cases of OFC are usually grouped by epidemiological studies as cleft lip, with or without cleft palate (CL/P), and cleft palate alone (CPO). Incidence of CL/P and CPO differs according to gender and ancestry and may vary widely across studies. Cases of OFC are characterized as either "syndromic" or "nonsyndromic," with further classification of nonsyndromic cases into isolated cases and cases that present with additional malformations. The genetic bases for many syndromic cases of OFC have been previously elucidated. Genetic associations have been described for nonsyndromic OFC as well. Importantly, etiology of OFC is known to involve interaction between genetic and environmental factors, including maternal nutrition and exposure to teratogenic agents. Furthermore, evidence points toward epigenetic as well as genetic factors influencing OFC etiology. Recent studies have begun to explore the association between CL/P and cancer. These studies report higher incidence of cancer among patients with CL/P and their family members as well as identification of common genetic markers mediating this increased risk, although much remains unknown about this link.

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Exposure During Pregnancy to Glycol Ethers and Chlorinated Solvents and the Risk of Congenital Malformations

Cited by 47 publications

References 27 publications

Assessed occupational exposure to chlorinated, aromatic and Stoddard solvents during pregnancy and risk of fetal growth restriction

Assessed occupational exposure to chlorinated, aromatic and Stoddard solvents during pregnancy and risk of fetal growth restriction

Prenatal exposure to glycol ethers and cryptorchidism and hypospadias: a nested case–control study

8 Epidemiology of Cleft Lip and Palate

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