2022
DOI: 10.3390/ijerph19063737
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Exposure to Antineoplastic Drugs in Occupational Settings: A Systematic Review of Biological Monitoring Data

Abstract: The high toxicity of antineoplastic drugs (ADs) makes them dangerous not only for patients, but also for exposed workers. Therefore, the aim of this review was to provide an updated overview of the biological monitoring of occupational AD exposure in order to extrapolate information useful to improve risk assessment and management strategies in workplaces. Several studies demonstrated that remarkable portions of healthcare workers may have traces of these substances or their metabolites in biological fluids, a… Show more

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Cited by 18 publications
(11 citation statements)
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“…In addition, most of the available data relate to pharmacists, pharmacy technicians, and nurses. A systematic review of ANDs biological monitoring data was performed recently by [ 11 ].…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…In addition, most of the available data relate to pharmacists, pharmacy technicians, and nurses. A systematic review of ANDs biological monitoring data was performed recently by [ 11 ].…”
Section: Discussionmentioning
confidence: 99%
“…The choice was driven mainly by the frequency and amount handled. In addition, CP, IF, MTX, and 5FU were among the most studied ANDs for exposure assessment [ 11 ]. However, these markers were not systematically handled at the same time by all participants.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The exposure is primarily caused by skin contact with contaminated surfaces. Subsequent biological ( 3 ) and toxicological ( 4 ) research also confirm that healthcare practitioners continue to be exposed to residual levels of contaminants. Hence, it's critical to manage and reduce the risk of exposure for healthcare professionals.…”
Section: Introductionmentioning
confidence: 91%
“…In western countries, injectable chemotherapy preparations are mainly centralized in hospital pharmacies. It has led to the implementation of additional protective measures throughout the chemotherapy process and setting of environmental monitoring ( 5 ) or healthcare workers biological fluids monitoring ( 3 ). Nevertheless, a lack of adherence to safety protecting measures and cleaning procedures ( 6 9 ), and poor knowledge of contamination risk ( 10 12 ) still described in healthcare population.…”
Section: Introductionmentioning
confidence: 99%