Exposure to chlorinated solvents and lung cancer: results of the ICARE study

Mattei, Francesca; Guida, Florence; Matrat, M.; Cénée, Sylvie; Cyr, Diane; Sanchez, Marie; Radoï, Loredana; Menvielle, Gwenn; Jellouli, Fatima; Carton, Matthieu; Bara, Simona; Marrer, Émilie; Luce, Danièle; Stücker, Isabelle

doi:10.1136/oemed-2014-102182

Cited by 21 publications

(14 citation statements)

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“…Chlorinated organic solvents have been associated with numerous adverse health effects, including acute and chronic neurotoxicity, hepatitis, renal injury, dermatitis haematological effects, and lung cancer [24][25][26]. Furthermore, solvent exposure has been linked in epidemiological studies to the development of systemic sclerosis, a known cause of PVOD.…”

Section: Discussionmentioning

confidence: 99%

Occupational exposure to organic solvents: a risk factor for pulmonary veno-occlusive disease

et al. 2015

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Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension characterised by predominant remodelling of pulmonary venules. Bi-allelic mutations in the eukaryotic translation initiation factor 2α kinase 4 (EIF2AK4) gene were recently described as the major cause of heritable PVOD, but risk factors associated with PVOD remain poorly understood. Occupational exposures have been proposed as a potential risk factor for PVOD, but epidemiological studies are lacking.A case-control study was conducted in consecutive PVOD (cases, n=33) and pulmonary arterial hypertension patients (controls, n=65). Occupational exposure was evaluated via questionnaire interview with blinded assessments using an expert consensus approach and a job exposure matrix ( JEM).Using the expert consensus approach, PVOD was significantly associated with occupational exposure to organic solvents (adjusted OR 12.8, 95% CI 2.7-60.8), with trichloroethylene being the main agent implicated (adjusted OR 8.2, 95% CI 1.4-49.4). JEM analysis independently confirmed the association between PVOD and trichloroethylene exposure. Absence of significant trichloroethylene exposure was associated with a younger age of disease (54.8±21.4 years, p=0.037) and a high prevalence of harbouring bi-allelic EIF2AK4 mutations (41.7% versus 0%, p=0.015).Occupational exposure to organic solvents may represent a novel risk factor for PVOD. Genetic background and environmental exposure appear to influence the phenotypic expression of the disease. @ERSpublications Occupational exposure to organic solvents is a novel risk factor for pulmonary veno-occlusive disease

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Section: Discussionmentioning

confidence: 99%

Occupational exposure to organic solvents: a risk factor for pulmonary veno-occlusive disease

et al. 2015

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“…Among the 4047 eligible head and neck cancer cases, 596 (14.7%) patients could not be located, 299 (7.4%) died before the interview, and 225 (5.6%) could not be interviewed due to poor health. Among the 2927 potential subjects who were contacted, 2415 (82.5%) agreed to participate and were interviewed, on average, within three months of diagnosis [15, 16]. The present study was restricted to men, as women were analyzed separately [17], and to squamous cell carcinomas of the oral cavity (Codes of the International Classification of Diseases for Oncology, third edition (ICD-O-3): oral cavity (C00.3–9; C02.0–3; C03.0–1; C03.9, C04.0–1; C04.8–9; C05.0; C06.0–2; C06.8–9),oropharynx (C01.9; C02.4; C05.1–2; C09.0–1; C09.8–9; C10.0–4; C10.8–9), hypopharynx (C12.9; C13.0–2; C13.8; C13.9), oral cavity or pharynx not otherwise specified or overlapping (C02.8, C02.9, C05.8, C05.9, C14.0, C14.2, C14.8) and larynx (C32.0–3; C 32.8–9).…”

Section: Methodsmentioning

confidence: 99%

Occupational exposure to chlorinated solvents and risk of head and neck cancer in men: a population-based case-control study in France

et al. 2017

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BackgroundFew epidemiological studies have investigated the link between occupational exposure to solvents and head and neck cancer risk, and available findings are sparse and inconsistent. The objective of this study was to examine the association between occupational exposure to chlorinated solvents and head and neck cancer risk.MethodsWe analyzed data from 4637 men (1857 cases and 2780 controls) included in a population-based case-control study, ICARE (France). Occupational exposure to five chlorinated solvents (perchloroethylene [PCE], trichloroethylene [TCE], methylene chloride [MC], chloroform [CF], and carbon tetrachloride [CT]) was assessed through job-exposure matrices. Odds ratios (ORs) and confidence intervals (95% CI) were estimated by unconditional logistic regression, adjusted for age, tobacco smoking, alcohol consumption, asbestos exposure, and other potential confounders.ResultsWe observed no association between chlorinated solvent exposure and head and neck cancer risk, despite a non-significant increase in risk among subjects who had the highest cumulative level of exposure to PCE, (OR = 1.81; 95% CI = 0.68 to 4.82). In subsite analysis, the risk of laryngeal cancer increased with cumulative exposure to PCE (p for trend = 0.04). The OR was 3.86 (95% CI = 1.30 to 11.48) for those exposed to the highest levels of PCE. A non-significant elevated risk of hypopharyngeal cancer was also observed in subjects exposed to the highest levels of MC (OR = 2.36; 95% CI = 0.98 to 5.85).ConclusionOur findings provide evidence that high exposure to PCE increases the risk of laryngeal cancer, and suggest an association between exposure to MC and hypopharyngeal cancer. Exposure to other chlorinated solvents was not associated with the risk of head and neck cancer.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-017-0286-5) contains supplementary material, which is available to authorized users.

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“…A Swedish study conducted in a cohort of dyers and dry cleaners showed a significant 30% increase in the risk of lung cancer compared to expected frequencies, and the increase was stronger in women than men [48]. Similarly, two case-control studies found an increased risk in lung cancer related to perchloroethylene exposure [49, 50]. …”

Section: Introductionmentioning

confidence: 99%

“…insulators, ship builders, construction workers), however women also may have been exposed. For example, 64% of men and 23% of women were found to have a non-null probability of exposure to asbestos in a large case-control study conducted in France [50]. …”

Section: Introductionmentioning

confidence: 99%

Women Epidemiology Lung Cancer (WELCA) study: reproductive, hormonal, occupational risk factors and biobank

et al. 2017

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BackgroundLung cancer aetiology and clinical aspects have been mainly studied in men, although specific risk factors probably exist in women. Here we present the rationale, design and organization of the WELCA study (Women Epidemiology Lung CAncer) that has been launched to investigate lung cancer in women, focusing particularly on hormonal and occupational factors.Methods/DesignWELCA is a population based case-control study and planned to recruit 1000 cases and 1000 controls in three years, based on study power calculation. Eligible cases are female patients newly diagnosed with lung cancer, living in Paris and the Ile de France area and aged up to 75 years. Almost all Parisian pneumology and oncology clinical departments are involved. The control group is a random sample of the population living in the same area, frequency-matched on age and additionally stratified on the distribution of socio-professional categories of women residing there. After acquisition of written consent, research nurses administer standardized computer assisted questionnaires to all the subjects in face-to-face interviews and acquire anthropometric measures. Besides usual socio-demographic characteristics, information is gathered about menstrual and reproductive factors, hormonal treatments, lifestyle and leisure characteristics, occupational history, personal and familial medical history. Biological samples are also collected, in order to establish a biobank for molecular epidemiology studies. Molecular characteristics of the tumours will be obtained and patients will be followed up for five years.DiscussionThe WELCA study aims to answer key questions in lung cancer aetiology and clinical characteristics specifically in women. The role of hormonal impregnation is investigated, and the interactions with cigarette smoking or body mass index (BMI) will be analyzed in detail. The occupational history of the subjects is carefully reconstructed, focusing in particular on the service sector. The creation of a biobank for collection of serum, plasma, DNA and tumour tissue will allow the genetic and biochemical characterization of both the subjets and the tumours. The follow-up of the patients will help in disentangling the role of hormonal factors and tumour molecular characteristics in survival.

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Exposure to chlorinated solvents and lung cancer: results of the ICARE study

Abstract: These results suggest that exposure to PCE may constitute a risk factor for lung cancer, especially among women, who seem to have a higher prevalence of exposure than men.

Cited by 21 publications

References 29 publications

Occupational exposure to organic solvents: a risk factor for pulmonary veno-occlusive disease

Occupational exposure to organic solvents: a risk factor for pulmonary veno-occlusive disease

Occupational exposure to chlorinated solvents and risk of head and neck cancer in men: a population-based case-control study in France

Women Epidemiology Lung Cancer (WELCA) study: reproductive, hormonal, occupational risk factors and biobank

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