Exposure to cobalt and nickel in the hard-metal production industry

Scansetti, G; Maina, Giovanni; Botta, Gianni; Bambace, Paolo; Spinelli, P.

doi:10.1007/s004200050251

Cited by 50 publications

(24 citation statements)

References 9 publications

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“…In general, the documented levels of metal ions in blood, plasma or urine of different types of implant [5][6][7][8][9][10][11][12][13] or correlated conditions like loosening [14,15] are not comparable with those observed in professionally exposed workers, due to the way of absorption (usually inhalation) and also the excretion rate is very different [16][17][18]. However, in both situations the risks connected with intoxication have been considered so far as potential.…”

Section: Introductionmentioning

confidence: 99%

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Cobalt, chromium and molybdenum ions kinetics in the human body: data gained from a total hip replacement with massive third body wear of the head and neuropathy by cobalt intoxication

Pazzaglia

Apostoli

Congiu

et al. 2011

Arch Orthop Trauma Surg

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Introduction A patient with a total hip replacement developed optic, acoustic and peripheral neuropathy from metal ions intoxication, due to the wear products released from the prosthesis. Subsequently the kinetics of the metal ions was studied. Materials and methods Massive wear and acute intoxication allowed a study of the metal ions kinetics and of EDTA treatment. Results Plasma and other organic fluids were saturated by each of the metal ions released from the exposed surface according to the solubility of each ion; a larger fraction of Co ions was bound within red cells, while the plasmatic fraction appeared more movable. In a patient with a prosthesis subjected to wear, the ions released are from the prosthetic and from the debris surface (spread in the body). The latter is a function of the number and size of particles. Discussion Revision of the prosthesis from the point of view of the metal ions kinetics corresponded to a reduction of the releasing surface because of debris washed out by irrigation and tissue excision; however, the metal particles spread by lymphatic circulation continued to release ions even though the source of wear had been removed. Early diagnosis of high metal wear can be ascertained with mass spectrometry and after revision high levels of metal ions can only be reduced with repeated chelating treatment. It is preferable not to revise fractured ceramic components with a polyethylene-metal articulation.

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Section: Introductionmentioning

confidence: 99%

“…It nevertheless was an interesting case to apply and analyse the effects of the therapy with chelating agent (EDTA), which is already been studied and currently used only in occupational metal intoxications [16][17][18]25] but never before in a THR.…”

Section: Introductionmentioning

confidence: 99%

Cobalt, chromium and molybdenum ions kinetics in the human body: data gained from a total hip replacement with massive third body wear of the head and neuropathy by cobalt intoxication

Pazzaglia

Apostoli

Congiu

et al. 2011

Arch Orthop Trauma Surg

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“…Nickel is excreted mainly through the bile and urine. The nickel concentration in urine of normal human subjects is between 0.1 and 13.3 µg/L, whereas in urine of welders, nickel was found at concentrations > 18.5 µg/L (9,10).…”

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confidence: 99%

Effect of nickel sulfate on testicular steroidogenesis in rats during protein restriction.

Das

Dasgupta

2002

Environ Health Perspect

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Nickel, a widely used heavy metal, exerts potent toxic effects on peripheral tissues as well as on the reproductive system. Low dietary protein coupled with exposure to this metal induces more severe changes, including biochemical defects, structural disorders, and altered physiologic functions. This study was designed to assess the effects of nickel sulfate on testicular steroidogenesis and to ascertain whether such alterations are reversible with normal protein and protein-restricted dietary regime. Nickel sulfate [2 mg/100 g body weight (bw)] dissolved in double-distilled water was administered on alternate days for 10 doses in a normal protein diet (18% casein) and a protein-restricted diet (5% casein) to Wistar male albino rats (bw 160 +/- 5 g). Two groups, one with a normal protein diet and the other with a protein-restricted diet, served as controls. Twenty-four hours after the last treatment, all the animals except those in withdrawal groups were sacrificed by decapitation. We observed a significant reduction in the activities of the testicular steroidogenic enzymes and plasma testosterone concentration accompanied by a significant elevation in cholesterol and ascorbic acid level in both dietary groups. After 15 days of withdrawal from the nickel sulfate treatment, the testicular steroidogenic enzymes, along with plasma testosterone level, improved significantly in both normal protein-fed and protein-restricted dietary groups. The effects of nickel on testicular cholesterol and ascorbic acid concentration were also reduced after withdrawal. Our results indicate that nickel sulfate affects the steroidogenic enzymes, causing alteration in the formation of testosterone in both dietary groups, which was manifested in the elevated cholesterol and ascorbic acid level with decreased activities of steroidogenic enzymes in adult rats testes. However, these alterations were reversible in both groups of animals fed normal protein diets and protein-restricted diets.

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“…[1][2][3][4] Among the techniques available for the determination of trace metals in biological fluids, electrothermal atomic absorption spectrometry (ETAAS) is used by most clinical and occupational laboratories because of its speed, minimum need for sample preparation, possibility of automation and good sensitivity.5 However, the determination of cobalt and nickel in biological materials by ETAAS often suffers from matrix interference. 6 The interference, especially in the analysis of serum or plasm samples which constitute complicated protein matrices, will greatly affect the analytical results.…”

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Electrothermal Atomic Absorption Spectrometric Determination of Cobalt and Nickel in Serum with Deproteinization Technique

1999

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The determination of cobalt and nickel in biological and environmental samples has been done by various analytical methods. [1][2][3][4] Among the techniques available for the determination of trace metals in biological fluids, electrothermal atomic absorption spectrometry (ETAAS) is used by most clinical and occupational laboratories because of its speed, minimum need for sample preparation, possibility of automation and good sensitivity.5 However, the determination of cobalt and nickel in biological materials by ETAAS often suffers from matrix interference. 6 The interference, especially in the analysis of serum or plasm samples which constitute complicated protein matrices, will greatly affect the analytical results. 7,8 Many authors used background correction systems, matrix modifiers or various techniques to separate cobalt and nickel from the matrix to eliminate the spectral or chemical interference. 9,[10][11][12] The deproteinization technique for the determination of serum nickel has been described by Sunderman et al. 8 and appears to be the most sensitive and was clinically well documented. However, the serum cobalt analysis by the deproteinization technique, to our knowledge, has not been described.The aim of our investigation was to develop an ETAAS procedure with deproteinized pretreatment for the determination of cobalt and nickel in serum samples. The proposed and validated method was also applied to analyze the concentrations of cobalt and nickel in normal individuals, workers exposed to nickel, and patients with breast cancer.

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Exposure to cobalt and nickel in the hard-metal production industry

Cited by 50 publications

References 9 publications

Cobalt, chromium and molybdenum ions kinetics in the human body: data gained from a total hip replacement with massive third body wear of the head and neuropathy by cobalt intoxication

Cobalt, chromium and molybdenum ions kinetics in the human body: data gained from a total hip replacement with massive third body wear of the head and neuropathy by cobalt intoxication

Effect of nickel sulfate on testicular steroidogenesis in rats during protein restriction.

Electrothermal Atomic Absorption Spectrometric Determination of Cobalt and Nickel in Serum with Deproteinization Technique

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