Exposure to Diabetes in Utero Is Associated with Earlier Pubertal Timing and Faster Pubertal Growth in the Offspring: The EPOCH Study

Hockett, Christine W.; Bedrick, Edward J.; Zeitler, Philip; Crume, Tessa; Daniels, Stephen R.; Dabelea, Dana

doi:10.1016/j.jpeds.2018.10.053

Cited by 19 publications

(36 citation statements)

References 41 publications

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“…Adiposity and 'over-nutrition' can be considered predictors of pubertal timing and principal determinants for the initiation and maintenance of pubertal maturational events (32), hence, the association between maternal GDM and offspring pubertal timing could be mediated by offspring adiposity and pre-adolescence BMI. This is supported by the analysis by Hockett et al (26), in which the association between maternal GDM and age at PHV is attenuated by adjustment for offspring BMI z-score.…”

Section: Discussionmentioning

confidence: 55%

“…Of the remaining 248, were not relevant to the research question and were excluded on the basis of title and abstract, leaving 18 studies for full-text assessment. Eleven articles were excluded at this stage: four articles were conference proceedings, oral presentations or commentary articles (13)(14)(15)(16); two articles did not include any of the outcomes we were interested in (17,18); one article did not analyse GDM as a predictor for pubertal timing due to an insufficient number of subjects with GDM (19); two articles did not provide a comparator cohort (20,21); two articles only reported Tanner stage at baseline and did not consider age/timing of puberty (22,23). The seven remaining studies were included in the review (Fig.…”

Section: Literature Search Resultsmentioning

confidence: 99%

“…age of transition to PH3 was 12.6 (95%CI 12.4, 12.7) for boys born to mothers with GDM compared to the entire cohort's median age of 12.8 (95%CI 12.7, 12.8). In the model with height and weight anthropometrics instead of BMI, median age of transition to PH3 for boys born to mothers with GDM was 12.8 [95%CI 12.6, 13.0] compared to the entire cohort's median Hockett et al(26) did not find a significant association between the age at PHV among boys and the GDM status of their mothers. However, they reported was a 4% increased PHV among boys born to mothers with GDM compared to boys born to mothers without GDM after adjusting for race/ethnicity (Table 3).…”

mentioning

confidence: 93%

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Pubertal timing in boys and girls born to mothers with gestational diabetes mellitus: a systematic review

Subramanian

Idkowiak

Toulis

et al. 2020

Preprint

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Context: The incidence of gestational diabetes mellitus (GDM) has been on the rise, driven by maternal obesity. In parallel, pubertal tempo has increased in the general population, driven by childhood obesity. Ojective: To evaluate the available evidence on pubertal timing of boys and girls born to mothers with GDM. Data Sources: We searched MEDLINE, EMBASE, CINAHL Plus, Cochrane library and grey literature for observational studies up to October 2019. Study selection and extraction: Two reviewers independently selected studies, collected data and appraised study quality. Results were tabulated and narratively described as reported in the primary studies. Results: Seven articles (six for girls and four for boys) were included. Study quality score was mostly moderate (ranging from 4 to 10 out of 11). In girls born to mothers with GDM, estimates suggest earlier timing of pubarche, thelarche and menarche although for each of these outcomes only one study each showed a statistically significant association. In boys, there was some association between maternal GDM and earlier pubarche, but inconsistency in the direction of shift of age at onset of genital and testicular development and first ejaculation. Only a single study analysed growth patterns in children of mothers with GDM, describing a 3-month advancement in the age of attainment of peak height velocity and a slight increase in pubertal tempo. Conclusions: Pubertal timing may be influenced by the presence of maternal GDM, though current evidence is sparse and of limited quality. Prospective cohort studies should be conducted, ideally coupled with objective biochemical tests.

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Section: Discussionmentioning

confidence: 55%

Section: Literature Search Resultsmentioning

confidence: 99%

mentioning

confidence: 93%

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Pubertal timing in boys and girls born to mothers with gestational diabetes mellitus: a systematic review

Subramanian

Idkowiak

Toulis

et al. 2020

Preprint

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“…He concluded that height during puberty needs to be measured only annually and, with slightly lower precision, just four biennial measurements can be sufficient [7]. aPHV and PHV were modeled using the SITAR method and they found that median aPHV was reached approximately three months earlier in youth exposed to maternal diabetes compared with unexposed youth (p < 0.03) [15]. Youth exposed to maternal diabetes had a faster PHV than unexposed youth: exposed girls had a 10.5% greater median PHV compared with unexposed girls, and exposed boys had a 4.0% greater median PHV compared with unexposed boys (p < 0.001 for exposure by sex interaction) [15].…”

Section: Discussionmentioning

confidence: 99%

Using the SITAR Method to Estimate Age at Peak Height Velocity of Children in Rural South Africa: Ellisras Longitudinal Study

et al. 2020

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Various studies have been conducted on children using the Ellisras Longitudinal Study Survey in South Africa, but none of these has addressed growth variations of children in this rural location. The aim of this paper is to assess the age at peak height velocity using the superimposition by translation and rotation (SITAR) method for both boys and girls in rural South Africa. The study is part of the on-going Ellisras Longitudinal Study, and has employed secondary data during the period from November 1996 to November 2003. The data was collected biannually in May and November each year. The Ellisras study initially followed a cluster sampling method. All participating children underwent a series of anthropometric measurements of height and weight according to the standard procedures recommended by the International Society for the Advancement of Kinanthropometry. The analysis was done using the SITAR model. Age at peak height velocity for Ellisras rural children was at 14.45 years for boys at 11.82 years for girls. Ellisras rural girls had their age at peak height velocity way earlier than Ellisras rural boys did by an estimated 2.63 years. Ellisras rural children and their growth variations were comparable to other studies.

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“…Pubic hair development/Pubarche: There was an inconsistent association between maternal GDM and pubarche in girls based on the four primary articles that studied this association. Age at peak height velocity: Hockett et al (27) examined the association between maternal GDM and pubertal timing in the daughters as reflected by growth parameters including peak height velocity (PHV) and age at PHV (APHV). APHV was 10.85 years in girls born to mothers with GDM and 11.12 years in girls born to mothers without GDM, with overlapping confidence intervals ( Table 2).…”

Section: Association Between Maternal Gestational Diabetes and Pubertmentioning

confidence: 99%

Pubertal timing in boys and girls born to mothers with gestational diabetes mellitus: a systematic review

Subramanian

Idkowiak

Toulis

et al. 2021

European Journal of Endocrinology

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Context: The incidence of gestational diabetes mellitus (GDM) has been on the rise, driven by maternal obesity. In parallel, pubertal tempo has increased in the general population, driven by childhood obesity. Objective: To evaluate the available evidence on pubertal timing of boys and girls born to mothers with GDM. Data Sources: We searched MEDLINE, EMBASE, CINAHL Plus, Cochrane library and grey literature for observational studies up to October 2019. Study selection and extraction: Two reviewers independently selected studies, collected data and appraised the studies for risk of bias. Results were tabulated and narratively described. Results: Seven studies (six for girls and four for boys) were included. Study quality score was mostly moderate (ranging from 4 to 10 out of 11). In girls born to mothers with GDM, estimates suggest earlier timing of pubarche, thelarche and menarche although for each of these outcomes only one study each showed a statistically significant association. In boys, there was some association between maternal GDM and earlier pubarche, but inconsistency in the direction of shift of age at onset of genital and testicular development and first ejaculation. Only a single study analysed growth patterns in children of mothers with GDM, describing a 3-month advancement in the age of attainment of peak height velocity and a slight increase in pubertal tempo. Conclusions: Pubertal timing may be influenced by the presence of maternal GDM, though current evidence is sparse and of limited quality. Prospective cohort studies should be conducted, ideally coupled with objective biochemical tests.

show abstract

Exposure to Diabetes in Utero Is Associated with Earlier Pubertal Timing and Faster Pubertal Growth in the Offspring: The EPOCH Study

Cited by 19 publications

References 41 publications

Pubertal timing in boys and girls born to mothers with gestational diabetes mellitus: a systematic review

Pubertal timing in boys and girls born to mothers with gestational diabetes mellitus: a systematic review

Using the SITAR Method to Estimate Age at Peak Height Velocity of Children in Rural South Africa: Ellisras Longitudinal Study

Pubertal timing in boys and girls born to mothers with gestational diabetes mellitus: a systematic review

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