Exposure to environmental chemical mixtures is associated with nasal colonization by Staphylococcus aureus: NHANES 2001–2004

Eggers, Shoshannah; Gennings, Chris; Malecki, Kristen; Safdar, Nasia; Arora, Manish

doi:10.1016/j.envres.2020.109994

Cited by 6 publications

(3 citation statements)

References 35 publications

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“…There are two main reasons for this approach. First, adding further adjustments for variables that are already accounted for in the calculation of sampling weights (such as age, race/ethnicity, and sex) in our regression analyses may decrease the precision of our estimates and potentially introduce an over-adjustment bias [24] . Secondly, the current version of the R package for WQS regression does not support the incorporation of variables related to complex survey structures [25] .…”

Section: Discussionmentioning

confidence: 99%

Association of exposure to per- and polyfluoroalkyl substances with liver injury in American adults

Yan,

Zhang,

et al. 2024

J Biomed Res

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Epidemiological data is scarce regarding the association between exposure to mixtures of per-and polyfluoroalkyl substances (PFASs) and liver injury in the general populace. The current research used data from the National Health and Nutrition Examination Survey (2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018). The PFAS exposure levels were defined by the serum concentrations of PFASs with > 70% detection in samples, namely perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorohexane sulfonic acid (PFHxS), perfluorodecanoic acid (PFDeA), and perfluorooctane sulfonic acid (PFOS). Liver injury was assessed from two aspects: first, the degree of liver inflammation was determined based on serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), glutamyltransferase (GGT), and total bilirubin (TBIL) levels; second, the degree of liver fibrosis was determined based on fibrosis-4 (FIB-4) index. We assessed the associations between individual or total PFAS exposure and these outcomes using multivariable linear regression models and logistic regression models, restricted cubic splines, and weighted quantile sum regression. Among the samples of 7484 American adults, the median concentration of PFOS was the highest, followed by PFOA and PFHxS. Using multivariable linear regression, a positive correlation was observed between all PFASs and liver enzymes such as ALT, AST, and TBIL. Additionally, the weighted quantile sum model indicated an overall positive association between the five PFASs and liver injury indicators. For liver function biomarkers and liver fibrosis, PFNA and PFOS were the most heavily weighting chemicals, respectively. Our findings provide new epidemiological evidence indicating a potential association between PFAS exposure and adverse effects on liver injury biomarkers, highlighting the potentially harmful effects of PFAS exposure on liver health.

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Section: Discussionmentioning

confidence: 99%

Association of exposure to per- and polyfluoroalkyl substances with liver injury in American adults

Yan,

Zhang,

et al. 2024

J Biomed Res

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“…In this community-based study, urban environmental factors had a more significant effect on SA carriage than individual host factors. In a study based on the National Health and Nutrition Examination Survey (NHANES), 2001–2004 data showed that mixtures within metals, phthalates, and phenols were associated with SA carriage [ 11 ]. Particulate matter (PM), such as black carbon, has also been reported to be associated with the nasal microbiome change including SA in the nasopharynx [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Differences between Staphylococcus aureus nasal carriage and IgE-sensitization to Staphylococcus aureus enterotoxin on risk factors and effects in adult population

Park

Yoo

Kim

et al. 2022

Allergy Asthma Clin Immunol

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Background Staphylococcus aureus (SA) nasal carriage (SA carriage) and IgE-sensitization to SA enterotoxin (SE IgE-sensitization) are known to be associated with chronic airway disease. Objective This study aimed to evaluate the differences in risk factors, type 2 inflammation and respiratory symptoms between SA carriage and SE IgE-sensitization. Methods We conducted a cross-sectional study of a community-based adult population to evaluate the environmental exposure and health impact of the Pohang Industrial Complex, Korea. Participants were examined based on self-reported questionnaires, nasal swab, and blood sampling. Results There were 307 participants, and the overall prevalence of SA carriage and SE IgE-sensitization was 26.1% (80/307) and 25.7% (79/307), respectively. An urban environment was significantly correlated with SA carriage, whereas age and obesity were significantly correlated with SE IgE-sensitization. SA carriage was not associated with an increase in total IgE and blood eosinophil count, whereas SE IgE-sensitization was associated with an increased total IgE and blood eosinophil count. SA carriage was significantly correlated with cough persisting for more than three weeks (OR, 3.044; 95% CI, 1.137–8.153) and sputum (OR, 2.429; 95% CI, 1.008–5.854). SE IgE-sensitization was a significant correlation with only sputum (OR, 2.452; 95% CI, 1.066–5.640). SA carriage and SE IgE-sensitization showed a synergistic effect on the prevalence of cough and sputum. Conclusion SA carriage was associated with the urban environment, and SE IgE-sensitization was associated with the elderly and obesity. SA carriage and SE IgE-sensitization had different correlation with type 2 inflammation and airway symptoms.

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“…Prenatal PBDE levels were associated with changes in microbiome profiles. Additionally, one study analysed cross‐sectional NHANES data on one component of the nasal microbiome: Staphylococcus aureus (Eggers et al., 2020 ). Eleven PBDEs (including BDE‐28 , ‐ 47 , ‐ 99 , ‐ 100 , ‐ 153 , ‐ 154 and ‐ 183 ) were evaluated in a mixture analysis in 1756 subjects and were not associated with the nasal colonisation by S. aureus .…”

Section: Assessmentmentioning

confidence: 99%

Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food

Schrenk,

Bignami,

Bodin

et al. 2024

EFS2

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The European Commission asked EFSA to update its 2011 risk assessment on polybrominated diphenyl ethers (PBDEs) in food, focusing on 10 congeners: BDE‐28, ‐47, ‐49, ‐99, ‐100, ‐138, ‐153, ‐154, ‐183 and ‑209. The CONTAM Panel concluded that the neurodevelopmental effects on behaviour and reproductive/developmental effects are the critical effects in rodent studies. For four congeners (BDE‐47, ‐99, ‐153, ‐209) the Panel derived Reference Points, i.e. benchmark doses and corresponding lower 95% confidence limits (BMDLs), for endpoint‐specific benchmark responses. Since repeated exposure to PBDEs results in accumulation of these chemicals in the body, the Panel estimated the body burden at the BMDL in rodents, and the chronic intake that would lead to the same body burden in humans. For the remaining six congeners no studies were available to identify Reference Points. The Panel concluded that there is scientific basis for inclusion of all 10 congeners in a common assessment group and performed a combined risk assessment. The Panel concluded that the combined margin of exposure (MOET) approach was the most appropriate risk metric and applied a tiered approach to the risk characterisation. Over 84,000 analytical results for the 10 congeners in food were used to estimate the exposure across dietary surveys and age groups of the European population. The most important contributors to the chronic dietary Lower Bound exposure to PBDEs were meat and meat products and fish and seafood. Taking into account the uncertainties affecting the assessment, the Panel concluded that it is likely that current dietary exposure to PBDEs in the European population raises a health concern.

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Exposure to environmental chemical mixtures is associated with nasal colonization by Staphylococcus aureus: NHANES 2001–2004

Cited by 6 publications

References 35 publications

Association of exposure to per- and polyfluoroalkyl substances with liver injury in American adults

Association of exposure to per- and polyfluoroalkyl substances with liver injury in American adults

Differences between Staphylococcus aureus nasal carriage and IgE-sensitization to Staphylococcus aureus enterotoxin on risk factors and effects in adult population

Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food

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