Exposure to Famine in Early Life and Nonalcoholic Fatty Liver Disease in Adulthood

Wang, Ningjian; Chen, Yi; Zhang, Ning; Qin, Li; Han, Bing; Zhu, Chunfang; Xia, Fangzhen; Jiang, Boren; Wang, Bingshun; Wang, Xiaojin; Jensen, Michael D.; Lu, Yingli

doi:10.1210/jc.2016-1076

Cited by 93 publications

(95 citation statements)

References 35 publications

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“…Our data (n = 6899) were from the SPECT-China study 54, 55 . The sampling method was described in detail in our previous study 23 .…”

Section: Methodsmentioning

confidence: 99%

“…The questionnaires about demographic characteristics, medical history and lifestyle risk factors and anthropometric data were constructed by the same trained staff as previously described 54, 55 . Body weight, height and the calculation of BMI were calculated consistently with the previous study 23 .…”

Section: Methodsmentioning

confidence: 99%

“…Venous blood samples were drawn, processed and shipped as previously described 54, 55 . Serum UA levels were measured using the uricase method with a Beckman Coulter AU 680 (Germany).…”

Section: Methodsmentioning

confidence: 99%

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Cadmium exposure and its association with serum uric acid and hyperuricemia

Sun

Wang

Chen

et al. 2017

Sci Rep

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Few studies have investigated the association between serum uric acid (UA) and cadmium exposure. Our previous study revealed a significantly higher blood cadmium (CdB) level in the Chinese population compared to populations in other countries. To determine whether CdB in Chinese adults is associated with serum UA and hyperuricemia, 2996 participants from the cross-sectional SPECT-China study were recruited. CdB was measured by atomic absorption spectrometry. Hyperuricemia was defined as a serum UA concentration ≥416.4 μmol/L for men and ≥356.9 μmol/L for women. Regression analyses were used to analyze the association of CdB with serum UA and hyperuricemia. We found that the median CdB level was higher in men with hyperuricemia (2.40 μg/L) than in men without hyperuricemia (1.98 μg/L, P < 0.05). A positive relationship between serum UA and CdB was found in Chinese men after adjusting for the estimated glomerular filtration rate (eGFR), current smoking status, diabetes, dyslipidemia, hypertension and body mass index and in participants with eGFR > 60 mL/min per 1.73 m2. Further, the odds ratio of hyperuricemia increased with increasing CdB quartiles (P for trend < 0.05) in men. In conclusion, CdB was positively related to the serum UA level and to hyperuricemia in Chinese men but not in Chinese women.

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“…Our data (n = 6899) were from the SPECT-China study 54, 55 . The sampling method was described in detail in our previous study 23 .…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Cadmium exposure and its association with serum uric acid and hyperuricemia

Sun

Wang

Chen

et al. 2017

Sci Rep

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“…In the same cohort, prenatal exposure to famine was associated with a more atherogenic lipid profile than those who were not exposed to famine in utero 18 . Early-life exposure to famine during the Great Chinese Famine (1958–1961) was associated with a sex-specific increase in the prevalence of moderate–severe NAFLD in adulthood, providing direct evidence of the link between poor fetal nutrition and perturbed liver function 19 .…”

Section: Liver Physiologymentioning

confidence: 99%

Endocrine-disrupting chemicals and fatty liver disease

et al. 2017

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Nonalcoholic fatty liver disease (NAFLD) is a growing epidemic paralleling the increase in obesity and diabetes mellitus seen in Western diet-consuming countries. As NAFLD can lead to life-threatening conditions such as cirrhosis and hepatocellular carcinoma (HCC), an understanding of factors that trigger its development and pathological progression is needed. Although by definition this disease is not associated with alcohol consumption, exposure to environmental agents that have been linked to other diseases might have a role in the development of NAFLD. Here, we focus on one class of these agents, endocrine-disrupting chemicals (EDCs), and their potential to influence the initiation and progression of a cascade of pathological conditions associated with fatty liver. Experimental studies have revealed several potential mechanisms by which EDC exposures might contribute to disease pathogenesis, including modulation of nuclear hormone receptor (NR) function and alteration of the epigenome. However, many questions remain to be addressed about the causal link between acute and chronic EDC exposure and the development of NAFLD in humans. Future studies that address these questions hold promise not only for understanding the linkage between EDC exposure and liver disease, but for elucidating the molecular mechanisms underpinning NAFLD and the development of new prevention and treatment opportunities.

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“…The emerging pandemic was partially caused by population growth, rapidly aging and changes of diet and lifestyle [2, 3, 5]. However, recent studies indicated that the early life famine exposure also might increase the later susceptibility to some common chronic diseases [6], including metabolic syndrome [7], diabetes [8], and fatty liver disease [9]. …”

Section: Introductionmentioning

confidence: 99%

Fetal and infant exposure to severe Chinese famine increases the risk of adult dyslipidemia: Results from the China health and retirement longitudinal study

Wang

Yang

et al. 2017

BMC Public Health

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BackgroundTo explore the associations between the Chinese famine exposure in early life and the dyslipidemia in adulthood.MethodsWe selected 2752 participants from the baseline survey of China Health and Retirement Longitudinal Study (CHARLS) 2011–2012 to evaluate the associations of early life the Chinese famine exposure with risk of dyslipidemia in adulthood. Dyslipidemia was defined as TC (Total Cholesterol): HDL-C (High-Density Lipoprotein Cholesterol) ratio ≥ 5.0 or use cholesterol lowering drugs. Famine exposure cohorts were categorized by birthdates of participants. Binary logistics regression model was used to examine the associations of early-life famine exposure with the risk of dyslipidemia.ResultsThe dyslipidemia prevalence of the non-exposed cohort, fetal stage-, infant stage-, and preschool stage-exposed cohorts in adulthood was 15.7%, 23.1%, 22.0%, and 18.6%, respectively. Early-life exposure to the Chinese famine significantly increased LDL cholesterol concentrations in adulthood after adjusted for age. The risks of dyslipidemia in fetal (OR = 1.58; 95% CI: 1.23–2.03; P < 0.001) and infant (OR = 1.52; 95% CI: 1.15–2.00; P = 0.003) stage-exposed cohorts were significantly higher than the non-exposed cohort after adjusted for gender and current family economic status. Following gender stratification, we found that fetal (OR = 1.80; 95% CI: 1.26–2.57; P = 0.001), infant (OR = 1.75; 95% CI: 1.17–2.62; P = 0.006), and preschool (OR = 1.63; 95% CI: 1.10–2.42; P = 0.015) -stage exposure to severe famine aggravated the risk of dyslipidemia in female adults. However, the similar association was not observed for male adults.ConclusionsEarly-life exposure to severe Chinese famine could link with the higher dyslipidemia risk in female adulthood, but not in male adulthood. This gender-specific effect might be associated with the hypothesis that parents in China prefer boys to girls traditionally or survivors’ bias.Electronic supplementary materialThe online version of this article (doi:10.1186/s12889-017-4421-6) contains supplementary material, which is available to authorized users.

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Exposure to Famine in Early Life and Nonalcoholic Fatty Liver Disease in Adulthood

Cited by 93 publications

References 35 publications

Cadmium exposure and its association with serum uric acid and hyperuricemia

Cadmium exposure and its association with serum uric acid and hyperuricemia

Endocrine-disrupting chemicals and fatty liver disease

Fetal and infant exposure to severe Chinese famine increases the risk of adult dyslipidemia: Results from the China health and retirement longitudinal study

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