Exposure to multiple trace elements and miscarriage during early pregnancy: A mixtures approach

Lǚ, Yingying; Zhang, Yuqing; Guan, Quanquan; Xu, Lu; Zhao, Shuangshuang; Duan, Jiawei; Wang, Yan; Xia, Yankai; Xu, Qing

doi:10.1016/j.envint.2022.107161

Cited by 43 publications

(25 citation statements)

References 56 publications

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“…A significant association was found between Fe and Zn quartile concentrations and dyslipidemia, and a significant association was found between the quartile concentration of Zn and dyslipidemia in females. Then, the combined exposure effects were estimated using the BKMR model, addressing the limitations of the complex interactions that may exist between metals and the possible nonlinear and nonadditive relationships between metals and dyslipidemia [ 27 ]. The BKMR model results showed that in the total population, As in the metal mixture was positively associated with dyslipidemia.…”

Section: Discussionmentioning

confidence: 99%

Association between combined exposure to plasma heavy metals and dyslipidemia in a chinese population

et al. 2022

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Background Exposure to heavy metals in the environment is widespread, while the relationship between combined exposure to heavy metals and dyslipidemia is unclear. Methods A cross-sectional study was performed, and 3544 participants aged 30 years or older were included in the analyses. Heavy metal concentrations in plasma were based on inductively coupled plasma‒mass spectrometry. The relationship between heavy metals and dyslipidemia was estimated by logistic regression. BKMR was used to evaluate metal mixtures and their potential interactions. Results In logistic regression analysis, participants in the fourth quartile of Fe and Zn (Fe > 1352.38 µg/L; Zn > 4401.42 µg/L) had a relatively higher risk of dyslipidemia (Fe, OR = 1.13, 95% CI: 0.92,1.38; Zn, OR = 1.30, 95% CI: 1.03,1.64). After sex stratification, females in the third quartile of plasma Zn (1062.05-4401.42 µg/L) had a higher relative risk of dyslipidemia (OR = 1.75, 95% CI: 1.28, 2.38). In BKMR analysis, metal mixtures were negatively associated with dyslipidemia in females when all metal concentrations were above the 50th percentile. In the total population (estimated from 0.030 to 0.031), As was positively associated with dyslipidemia when other metals were controlled at the 25th, 50th, or 75th percentile, respectively, and As was below the 75th percentile. In females (estimated from − 0.037 to -0.031), Zn was negatively associated with dyslipidemia when it was above the 50th percentile. Conclusion This study indicated that As was positively associated with dyslipidemia and that Zn may be negatively associated with dyslipidemia in females. Combined metal exposure was negatively associated with dyslipidemia in females. Females with low plasma Zn levels are more likely to develop dyslipidemia and should receive more clinical attention in this population.

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Section: Discussionmentioning

confidence: 99%

Association between combined exposure to plasma heavy metals and dyslipidemia in a chinese population

et al. 2022

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“…Interestingly, we found that concentrations of Rb initially decreased but subsequently bounced back during pregnancy. Previous studies have reported that Rb exhibited negative associations with miscarriages [ 38 ]. To our knowledge, no previous research has reported similar results.…”

Section: Discussionmentioning

confidence: 99%

An Evaluation of Exposure to 18 Toxic and/or Essential Trace Elements Exposure in Maternal and Cord Plasma during Pregnancy at Advanced Maternal Age

Jia

Shi

et al. 2022

IJERPH

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Pregnant women of advanced maternal age (AMA) are vulnerable to exposure to the surrounding environment. Assessment of trace elements in pregnant women living in specific areas is important for biomonitoring. However, exposure levels and variation patterns during pregnancy remains controversial and attracts extensive public concern. Therefore, we aimed to evaluate exposure of 18 toxic and/or essential trace elements in maternal plasma and in paired cord plasma during pregnancy at AMA. A total of 48 pregnant women of AMA were recruited in Peking University Third Hospital from 2018 to 2021. Eighteen elements found in maternal plasma during the 1st, 2nd, or 3rd trimester of pregnancy and paired cord plasma were measured by 7700x ICP-MS (Agilent Technologies, Palo Alto, CA, USA) and Elan DRC type II ICP-MS (The Perkin-Elmer Corporation, Waltham, MA USA). Concentrations of Pb, Se, Fe, Zn, and Mo all decreased during pregnancy, while Cu increased. Interestingly, concentrations of Rb decreased initially but then increased. Elements as Al, Co, Se, Cu, and Ni showed significantly lower levels in cord than in maternal plasma, while elements as Sr, Fe, Rb, Mn and Zn displayed significantly higher levels in cord than in maternal plasma. Moreover, positively- interacted clusters were found in Ni-Co-Cu-Al-Rb-Zn and Zn-Mn-Al-Pb in maternal blood. Similar positively-interacted clusters were found in Zn-Ni-Co, Zn-Ni-Fe, Mn-Al-Pb, Fe-Pb-Mn, Fe-Ni-Cu, and Rb-Cu-Sb-Fe-Mn in cord plasma. Furthermore, correlations between paired maternal and cord blood samples for As, Sr, and Mo were statistically significant, indicating that the fetus burden may reflect maternal exposure to some extent. Admittedly, levels of toxic and essential elements in our cohort study were comparatively lower than those in the scientific literature.

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“…Previous studies reported that Rb exhibited negative associations with miscarriage. [37] The interesting variation pattern cannot be explained to our knowledge yet. No previous research has reported similar results to our knowledge.…”

Section: Concentration Of Trace Elements During Pregnancymentioning

confidence: 94%

Evaluate levels of 18 toxic and/or essential trace elements exposure in maternal and cord plasma during pregnancy at advanced maternal age

Jia

Shi

et al. 2022

Preprint

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Pregnant women with advanced maternal age (AMA) are vulnerable to the surrounding environment exposure. Assessment of the trace elements in pregnant women living in specific areas is important for biomonitoring. However, the exposure levels and variation pattern of elements’ exposure during pregnancy is still controversial and attracting extensive public concern. Therefore, we aimed to evaluate exposure of 18 toxic and/or essential trace elements’ exposure in maternal plasma during pregnancy of AMA and in paired cord plasma. A total of 48 pregnant women with AMA were recruited in Peking University Third Hospital from 2018 to 2021. 18 elements of Maternal plasma in 1st, 2nd, 3rd pregnancy and paired cord plasma were measured by 7700x ICP-MS (Agilent Technologies, USA) and Elan DRC type II ICP-MS (The Perkin-Elmer Corporation, USA). Concentrations of Pb, Se, Fe, Zn, Mo all decreased during pregnancy, while Cu increased in the opposite. Interestingly, concentrations of Rb decreased first but subsequently increased. Elements as Al, Co, Se, Cu, Ni showed significantly lower levels in cord than in maternal plasma, while elements as Sr, Fe, Rb, Mn, Zn displayed significantly higher levels in cord than in maternal plasma. What’s more, positively-interacted clusters were found in Ni-Co-Cu-Al-Rb-Zn and Zn-Mn-Al-Pb in maternal blood. Similar positively-interacted clusters were found in Zn-Ni-Co, Zn-Ni-Fe, Mn-Al-Pb, Fe-Pb-Mn, Fe-Ni-Cu and Rb-Cu-Sb-Fe-Mn in cord plasma. Last but not least, correlations between paired maternal and cord blood samples for As, Sr and Mo were statistically significant, indicating that the fetus burden might reflect the maternal exposure to some extent. Admittedly, levels of toxic and essential elements in our cohort study were comparatively lower in the scientific literature.

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Exposure to multiple trace elements and miscarriage during early pregnancy: A mixtures approach

Cited by 43 publications

References 56 publications

Association between combined exposure to plasma heavy metals and dyslipidemia in a chinese population

Association between combined exposure to plasma heavy metals and dyslipidemia in a chinese population

An Evaluation of Exposure to 18 Toxic and/or Essential Trace Elements Exposure in Maternal and Cord Plasma during Pregnancy at Advanced Maternal Age

Evaluate levels of 18 toxic and/or essential trace elements exposure in maternal and cord plasma during pregnancy at advanced maternal age

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