Exposure to Music and Noise During Pregnancy Influences Neurogenesis and Thickness in Motor and Somatosensory Cortex of Rat Pups

Kim, Chang-Hee; Lee, Sangchul; Shin, Je Wook; Chung, Kyung Jin; Lee, Shin-Ho; Shin, Mal‐Soon; Baek, Sang‐Bin; Sung, Yun‐Hee; Kim, Chang‐Ju; Kim, Khae Hawn

doi:10.5213/inj.2013.17.3.107

Cited by 27 publications

(26 citation statements)

References 30 publications

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“…For the detection of newly generated cells in the dentate gyrus, BrdU-specific immunohistochemistry was performed as previously described ( Cho et al, 2013 ; Kim et al, 2013 ). Five sections on average were selected in each brain region spanning from Bregma −3.30 mm to −4.16 mm.…”

Section: Methodsmentioning

confidence: 99%

The impact of duration of one bout treadmill exercise on cell proliferation and central fatigue in rats

et al. 2013

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The purpose of this study was to investigate the impact of the duration-dependence of the one bout treadmill exercise on cell proliferation, stress, and central fatigue in rats. The animals were randomly divided into five groups: the non-exercise group, 1-h exercise group, 2-h exercise group, 4-h exercise group, and 6-h exercise group. The exercise load consisted of running at speed of 13 meters/min with the 0° inclination. Cell proliferation in the hippocampal dentate gyrus was increased in response to one bout moderate treadmill exercise in all exercise groups. But there was no statistical significance between the exercise duration and cell proliferation. The optical density of glucocorticoid (GR)-positive cells in the hippocampal dentate gyrus was not changed by treadmill exercise at any exercise duration. Expressions of serotonin (5-hydroxytryptamine, 5-HT) and tryptophan hyroxylase (TPH) were increased by treadmill exercise only at 6 h duration. It seemed like that there was no additional benefits on cell proliferation over 2 h exercise due to stressful factors with over exercise dose, and there was no change of GR expression due to early assessment point of time. It can be suggested that the one-bout of moderate treadmill exercise increased cell proliferation, but treadmill exercise prolonged to 6 h induced central fatigue in rats.

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Section: Methodsmentioning

confidence: 99%

The impact of duration of one bout treadmill exercise on cell proliferation and central fatigue in rats

et al. 2013

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“…Hence, Kim et al . [ 17 ] separated pregnant rats into two groups and had one group listen to the noise and the other group to the music. They detected that there were decreases in the motor cortex and somatosensory cortical thicknesses and in the neurogenesis of the offspring of rats exposed to the noise, while in contrast, these values increased in those exposed to the music, and they provided evidences for neurological impact related to the noise.…”

Section: Discussion and Resultsmentioning

confidence: 99%

Investigation of the effect of the efficiency of noise at different intensities on the DNA of the newborns

et al. 2016

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Hearing loss can occur in newborns exposed to high-level noise; noise exposure can cause more physiological stress and can lead to DNA damage. This study was designed to determine DNA damage in newborn rats exposed to sound at different concentrations. For this purpose, 28 newborn (3-6 days old) rats were divided into four groups of 7 rats in each group (Control and Groups of 40 decibel (dB), 70 dB, and 110 dB]. In the experimental groups, 40 dB, 70 dB, and 110 dB (7.5-15 kHz) of sound was applied to the experimental groups for 30 min a day for 7 days. DNA damage levels in the serums obtained from this study were determined by the enzyme-linked immunosorbent assay (ELISA) method. According to this, it was determined that DNA damage in the group exposed to 110 dB showed a statistically significant increase (P < 0.05) compared to the compared to the control, 40 dB, and 70 dB groups. Related to the subject, it was concluded that DNA damage may occur in newborns exposed to 110 dB or higher sound in neonatal units, wards, and home environments with newborn babies. Mothers should be warned about this situation and noise should be kept under 110 dB volume in the environments with the newborns.

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“…In contrast, prenatal music exposure can improve neurogenesis in the hippocampus and spatial ability in newborn mice. [60][61] Brains that grow in a stimulus-rich environment have thicker cortex, larger nucleus neuron cells and more glia cells. Brain neurons that grow in there have more dendritic sites, allowing more synapses to form.…”

Section: Discussionmentioning

confidence: 99%

Mozart Compilation During Pregnancy Gave Higher Number of Neurons of Rattus Norvegicus Offsprings in Cerebrum Compared to Jazz, Blues, and Rock Compilation

Syania¹,

Tj²,

Mudjiani³

2019

GJMR

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Aim:To analyze the difference of the number of neurons in the cerebrum of Rattus norvegicus offsprings exposed to Mozart, Jazz, Blues, and Rock compilations during pregnancy. Method:Experimental study with single-blind randomized post-test only control group design using Rattus norvegicusas animal subjects that were divided into four groups: Mozart, Jazz, Blues, and Rock groups. The exposures started from the 10 day of gestation for 1 hour in a dark atmosphere with an intensity of 60 dB, in a distance of 25 cm from the exposure box, during March-May 2019. After cesarean delivery at day 19, the offsprings brain were prepared and stained by Hematoxylin-Eosin, then analyzed in 5 fields in each hemisphere with 1000x magnifying microscope. The study was conducted after ethical clearance and used a comparison statistical test chosen accordingly. Result:There were significant differences of the number of neurons between Mozart (71,96 ± 14,44) with Jazz (41,06 ± 7,65), Blues(40,92 ± 6,36), and Rock group (31,31 ± 8,19) with p=0,000. Conclusion:The number of neurons in the cerebrum of Rattus norvegicus offsprings exposed to Mozart compilation during pregnancy proved to be higher than Jazz,Blues, and Rock compilations.

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Exposure to Music and Noise During Pregnancy Influences Neurogenesis and Thickness in Motor and Somatosensory Cortex of Rat Pups

Cited by 27 publications

References 30 publications

The impact of duration of one bout treadmill exercise on cell proliferation and central fatigue in rats

The impact of duration of one bout treadmill exercise on cell proliferation and central fatigue in rats

Investigation of the effect of the efficiency of noise at different intensities on the DNA of the newborns

Mozart Compilation During Pregnancy Gave Higher Number of Neurons of Rattus Norvegicus Offsprings in Cerebrum Compared to Jazz, Blues, and Rock Compilation

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