Exposure to Pb-halide perovskite nanoparticles can deliver bioavailable Pb but does not alter endogenous gut microbiota in zebrafish

Pb Toxicity on Gut Physiology and Microbiota

“…Consistently, the expression of glycolysis and lipid metabolism-related genes, including Gk , Aco , Acc1 , Fas , Apo , and Dgat , were notably declined ( Xia et al, 2018b ). Patsiou et al (2020) also reported a notable increase in the phylum of Alphaproteobacteria and a reduction in Gammaproteobacteria of zebrafish following Pb (500 mg/kg) exposure via drinking water for 14 days. At the order level, the relative abundance of Alteromonadales was decreased with significance.…”

“…At the order level, the relative abundance of Alteromonadales was decreased with significance. At the genus level, gut microbiota was featured by an upregulation in the relative abundance of Pseudomonas , Halomonadaceae , Arcobacter , and Polaribacter ( Patsiou et al, 2020 ). Interestingly, specific Pseudomonas strains were reported to be Pb-tolerant bacteria in Pb-contaminated water and soil ( Li D. et al, 2017 ), which revealed that some Pb-against bacteria may exist in zebrafish.…”

A systematic review on the effects of nanomaterials on gut microbiota

“… Nano-sized plastics (44 nm) Shrimp Aquatic 0, 50 μg/L for 21 days Changes in GM, amino acids and fatty acids as well as microbial activities 3 Chae et al. (2019) Lead-halide perovskite NPs (889 - 1206 nm) Zebra fish 24 hour aquatic exposure to 0, 5, 10, 50, 100 and 200 mg/L and dietary exposure (500 mg/kg) No significant changes in GM 5 Patsiou et al. (2020) CNFs and SDA CNFs Mice Oral administration 0.1% (v/v) in tap water for 28 days Increases in Bacteroidales as well as changes in the metabolism of acyl-carnitines and fatty acids 3 Azuma et al.…”

Resistance and Resilience of Fish Gut Microbiota to Silver Nanoparticles

“…For example, the rapid growth of Proteobacteria , which is considered a potential diagnostic signature of dysbiosis and disease risk, may induce the gut microbiota to an unstable state ( 44 , 45 ). The higher abundance of Proteobacteria was also a typical feature of zebrafish with inflammatory bowel disease induced by environmental pollutants ( 46 ). In contrast, the cooperation of beneficial microbes such as Fusobacteria , Bacteroidetes , and Firmicutes could result in gut stability by producing essential vitamins to assist in detoxification ( 47 ).…”