Exposure to Recurrent Sleep Restriction in the Setting of High Caloric Intake and Physical Inactivity Results in Increased Insulin Resistance and Reduced Glucose Tolerance

Nedeltcheva, Arlet; Kessler, Lynn; Imperial, Jacqueline; Penev, Plamen D.

doi:10.1210/jc.2009-0483

Cited by 276 publications

(280 citation statements)

References 33 publications

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“…Sleep restriction was associated with reduced insulin sensitivity in all the studies (except one (30) ), with reduced glucose tolerance in one of them (27) . The study that found no effect on glucose or insulin aimed to determine the hormonal effects of restricting sleep duration under controlled feeding conditions (30) .…”

Section: Evidence From Sleep Restriction Clinical Studiesmentioning

confidence: 87%

“…Multiple small laboratory-based crossover studies on healthy young participants have looked at the effect of sleep restriction on insulin sensitivity and glucose tolerance (26)(27)(28)(29)(30) . Sleep restriction was associated with reduced insulin sensitivity in all the studies (except one (30) ), with reduced glucose tolerance in one of them (27) .…”

Section: Evidence From Sleep Restriction Clinical Studiesmentioning

confidence: 99%

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The role of sleep duration in diabetes and glucose control

Alnaji

Law

2016

Proc. Nutr. Soc.

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Sleep curtailment is common in the Westernised world and coincides with an increase in the prevalence of type 2 diabetes mellitus (T2DM). This review considers the recently published evidence for whether sleep duration is involved in the development of T2DM in human subjects and whether sleep has a role to play in glucose control in people who have diabetes. Data from large, prospective studies indicate a U-shaped relationship between sleep duration and the development of T2DM. Smaller, cross-sectional studies also support a relationship between short sleep duration and the development of both insulin resistance and T2DM. Intervention studies show that sleep restriction leads to insulin resistance, with recent sleep extension studies offering tantalising data showing a potential benefit of sleep extension on glucose control and insulin sensitivity. In people with established diabetes the published literature shows an association between poor glucose control and both short and long sleep durations. However, there are currently no studies that determine the causal direction of this relationship, nor whether sleep interventions are likely to offer benefit for people with diabetes to help them achieve tighter glucose control

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Section: Evidence From Sleep Restriction Clinical Studiesmentioning

confidence: 87%

Section: Evidence From Sleep Restriction Clinical Studiesmentioning

confidence: 99%

The role of sleep duration in diabetes and glucose control

Alnaji

Law

2016

Proc. Nutr. Soc.

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“…Additionally, night‐time NSHEs directly compromise patients’ quality of sleep. This is a concern, because disruption to sleep has been associated with metabolic abnormalities that can increase the risk of future hypoglycemic episodes, creating a vicious cycle12, 13.…”

Section: Discussionmentioning

confidence: 99%

Diabetes management and daily functioning burden of non‐severe hypoglycemia in Japanese people treated with insulin

Ohashi

Wolden

Hyllested‐Winge³

et al. 2017

J of Diabetes Invest

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Aims/IntroductionThe present study investigated the impact of non‐severe hypoglycemic events (NSHE) on patients’ diabetes management, daily functioning and well‐being.Materials and MethodsA survey assessing the impact of NSHEs was completed by insulin‐treated Japanese people with diabetes, aged ≥20 years with self‐reported diabetes, who had experienced at least one NSHE in the past 3 months. Survey questions captured reasons for and the length of the event, and impacts on diabetes management, daily functioning, sleep and well‐being.ResultsA total of 3,145 people with type 1 diabetes mellitus and type 2 diabetes mellitus were screened, of which 411 respondents were eligible. Increased glucose monitoring was reported by 57 and 54% of respondents after daytime and night‐time NSHE, respectively. The average number of additional glucose monitoring tests was 2.4 and 3.0 for daytime and night‐time NSHE. Among all respondents, 19% (daytime) and 16% (night‐time) changed their insulin dose after an NSHE. After a daytime NSHE, 25% of respondents reported a negative impact on their daily activities or work. After a night‐time NSHE, 34 and 23% of respondents reported a negative impact on sleep and next day emotional state, respectively.Conclusions NSHEs have a negative impact on the diabetes management, daily functioning, sleep and well‐being of Japanese patients.

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“…Decreased sleep in humans is associated with weight gain, higher body mass index (BMI), greater body-fat percentage (Cappuccio et al, 2008;Patel and Hu, 2008), and impaired glucose metabolism (Hanlon and Van Cauter, 2011;Nedeltcheva et al, 2009). Remarkably, recent studies have shown that the positive energy-balance state incurred by sleep loss is accounted for by increased caloric intake outside of regular meals ('snacking'; Markwald et al, 2013), particularly on carbohydrate-or fat-enriched foods (Markwald et al, 2013;Nedeltcheva et al, 2009;Spiegel et al, 2004a;St-Onge et al, 2011;Weiss et al, 2010). There is much interest in identifying the physiological basis of these behavioral changes, and studies to date have focused mainly on peripheral endocrine systems (eg, leptin and ghrelin) that regulate feeding in conjunction with energy-balance fluctuations.…”

Section: Introductionmentioning

confidence: 99%

Upregulation of Gene Expression in Reward-Modulatory Striatal Opioid Systems by Sleep Loss

Baldo

Hanlon

Obermeyer

et al. 2013

Neuropsychopharmacol

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Epidemiological studies have shown a link between sleep loss and the obesity 'epidemic,' and several observations indicate that sleep curtailment engenders positive energy balance via increased palatable-food 'snacking.' These effects suggest alterations in rewardmodulatory brain systems. We explored the effects of 10 days of sleep deprivation in rats on the expression of striatal opioid peptide (OP) genes that subserve food motivation and hedonic reward, and compared effects with those seen in hypothalamic energy balanceregulatory systems. Sleep-deprived (Sleep-Dep) rats were compared with yoked forced-locomotion apparatus controls (App-Controls), food-restricted rats (Food-Restrict), and unmanipulated controls (Home-Cage). Detection of mRNA levels with in situ hybridization revealed a subregion-specific upregulation of striatal preproenkephalin and prodynorhin gene expression in the Sleep-Dep group relative to all other groups. Neuropeptide Y (NPY) gene expression in the hippocampal dentate gyrus and throughout neocortex was also robustly upregulated selectively in the Sleep-Dep group. In contrast, parallel gene expression changes were observed in the Sleep-Dep and Food-Restrict groups in hypothalamic energy-sensing systems (arcuate nucleus NPY was upregulated, and cocaine-and amphetamine-regulated transcript was downregulated), in alignment with leptin suppression in both groups. Together, these results reveal a novel set of sleep deprivation-induced transcriptional changes in reward-modulatory peptide systems, which are dissociable from the energy-balance perturbations of sleep loss or the potentially stressful effects of the forced-locomotion procedure. The recruitment of telencephalic food-reward systems may provide a feeding drive highly resistant to feedback control, which could engender obesity through the enhancement of palatable feeding.

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Exposure to Recurrent Sleep Restriction in the Setting of High Caloric Intake and Physical Inactivity Results in Increased Insulin Resistance and Reduced Glucose Tolerance

Abstract: Experimental bedtime restriction, designed to approximate the short sleep times experienced by many individuals in Westernized societies, may facilitate the development of insulin resistance and reduced glucose tolerance.

Cited by 276 publications

References 33 publications

The role of sleep duration in diabetes and glucose control

The role of sleep duration in diabetes and glucose control

Diabetes management and daily functioning burden of non‐severe hypoglycemia in Japanese people treated with insulin

Upregulation of Gene Expression in Reward-Modulatory Striatal Opioid Systems by Sleep Loss

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