Exposure to smoking-relevant cues: Effects on desire to smoke and topographical components of smoking behavior

Payne, Thomas J.; Schare, Mitchell L.; Levis, Donald J.; Colletti, Gep

doi:10.1016/0306-4603(91)90054-l

Cited by 154 publications

(132 citation statements)

References 31 publications

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“…In contrast to the predictions of appetitive-incentive [22] and incentive-sensitization [23] models of drug motivation that suggest drug cues prime central motivational systems mediating pleasure and positive affect, the limited number of studies assessing mood during cigarette craving have, in line with associative-withdrawal models of drug motivation, observed self-reported negative affect to accompany craving, and for negative affect manipulation to increase craving [24][25][26][27][28] . Thus, these observations of cue-elicited withdrawal-like responses appear to implicate relative right hemisphere involvement in smoking-related urges.…”

mentioning

confidence: 90%

Craving-Induced EEG Reactivity in Smokers: Effects of Mood Induction, Nicotine Dependence and Gender

Knott¹,

Naccache²,

Cyr³

et al. 2008

Neuropsychobiology

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Background/Aims: Cigarette craving is a core symptom of smoking withdrawal, which is more intense and more frequently observed in smokers with depressed mood. Using self-reports and electroencephalographic (EEG) indices of frontal hemispheric asymmetry, which has been shown to be sensitive to mood states, the purpose of this study was to investigate the neural basis of cue-elicited cigarette craving, its variation with experimentally induced depressed mood, and with differences in gender and smoker type. Methods: Cigarette-cue reactivity was examined in 11 (5 male) regular and 11 (6 male) light smokers in two sessions involving the induction of neutral or depressed mood. Results: Frontal EEG alpha asymmetry changes reflecting left frontal hypoactivation were evident with cigarette-cue exposure, particularly in female smokers. During cigarette-cue exposure, EEG evidenced both decreases and increases in brain state activation, with the latter activational increments also being influenced by depressed mood. Exposure to the cigarette cue, in addition to increasing withdrawal symptoms, increased cravings and negative affect, these latter effects being more evident in female and regular smokers. Conclusion: These findings, which appear to provide a physiological basis for ‘withdrawal-like’ negative affective experiences during craving, are discussed in relation to theories of drug reinforcement and smoking motivation.

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mentioning

confidence: 90%

Craving-Induced EEG Reactivity in Smokers: Effects of Mood Induction, Nicotine Dependence and Gender

Knott¹,

Naccache²,

Cyr³

et al. 2008

Neuropsychobiology

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“…The hypothesis that these stimuli can acquire reinforcing properties (i.e., sustain operant responding) and promote human smoking is widely endorsed by theoretical models (e.g., Caggiula et al 2001;Chiamulera 2005;Conklin and Tiffany 2002;Rose and Levin 1991) and has generally been supported by empirical studies of human smoking (Lazev et al 1999;Payne et al 1991). For example, stimuli with no historical affiliation to smoking can acquire conditional stimulus properties in the laboratory when they are paired with a period of free access to smoking (Lazev et al 1999).…”

Section: Introductionmentioning

confidence: 96%

Conditioned reinforcement in rats established with self-administered nicotine and enhanced by noncontingent nicotine

et al. 2007

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“…Nicotine is the principal psychoactive component of cigarette smoke and non-nicotine stimuli that become associated with nicotine delivery are thought to play an important role in the maintenance of smoking and in its relapse after attempted quitting (Caggiula et al, 2001;Childress et al, 1993;Niaura et al, 1989;O'Brien et al, 1998). Human studies have demonstrated that smoking cues increase the rate, intensity, and time of smoking (Mucha et al, 1998;Surawy et al, 1985) and significantly enhance desire to smoke (Drobes and Tiffany, 1997;Droungas et al, 1995;Lazev et al, 1999;Payne et al, 1991;Tiffany and Hakenewerth, 1991). Smoking denicotinized cigarettes (ie cue alone) produces comparable levels of smoke intake, satisfaction, and reduction of craving and withdrawal compared to smoking nicotine-containing cigarettes (ie cue plus nicotine) (Butschky et al, 1995;Dallery et al, 2003;Gross et al, 1997;Rose et al, 2000;Shahan et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Mecamylamine Attenuates Cue-Induced Reinstatement of Nicotine-Seeking Behavior in Rats

Liu

Caggiula

Yee

et al. 2006

Neuropsychopharmacol

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Mecamylamine, a noncompetitive nicotinic cholinergic antagonist, inhibits nicotine self-administration in animals and may attenuate tobacco smoking in humans trying to quit. Our preliminary data suggested that this agent, at a dose of 2 mg/kg (subcutaneous (s.c.)), also attenuates cue-induced relapse to nicotine-seeking behavior in rats. This study determined whether mecamylamine-induced attenuation can be obtained at doses lower than the high 2 mg/kg dose used in the first study, and whether it is specific to nicotine-associated cues. Male Sprague-Dawley rats were trained to intravenously self-administer nicotine (0.03 mg/kg/infusion) on a fixed-ratio 5 schedule. Each infusion was accompanied by a visual cue (1 s onset of a lever light followed by offset of a house light for 20 s during which time no infusions could be obtained). After the nicotine-maintained responding was extinguished by withholding the delivery of nicotine (saline substitution) and its associated cue, reinstatement tests were conducted. Response-contingent re-presentation of the cue without further availability of nicotine significantly reinstated extinguished responding at the previously nicotine-reinforced lever. Pretreatment with mecamylamine (0.5, 1, and 2 mg/kg, s.c.) dose-dependently attenuated the cue-induced reinstatement of lever responding. Mecamylamine did not change food-taking and -seeking responses, whereas the highest dose (2 mg/kg) decreased nicotine selfadministration behavior. The results confirm previous findings that stimuli conditioned to nicotine self-administration effectively elicit reinstatement of nicotine-seeking behavior after extinction and demonstrate that mecamylamine, besides suppressing self-administration of nicotine, effectively attenuates cue-induced nicotine-seeking behavior. These findings suggest that the response-reinstatement procedures used in this study may be useful for studying neurobiological mechanisms of nicotine-seeking behavior and that mecamylamine-like drugs may be potential candidates for pharmacological treatment and prevention of relapse to tobacco smoking in abstinent smokers.

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Exposure to smoking-relevant cues: Effects on desire to smoke and topographical components of smoking behavior

Cited by 154 publications

References 31 publications

Craving-Induced EEG Reactivity in Smokers: Effects of Mood Induction, Nicotine Dependence and Gender

Craving-Induced EEG Reactivity in Smokers: Effects of Mood Induction, Nicotine Dependence and Gender

Conditioned reinforcement in rats established with self-administered nicotine and enhanced by noncontingent nicotine

Mecamylamine Attenuates Cue-Induced Reinstatement of Nicotine-Seeking Behavior in Rats

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