Exposure to soil, house dust and decaying plants increases gut microbial diversity and decreases serum immunoglobulin <scp>E</scp> levels in <scp>BALB</scp>/c mice

Zhou, Dongrui; Zhang, Honglin; Bai, Zhimao; Zhang, Aidi; Bai, Futian; Luo, Xing; Hou, Yue; Ding, Xiao; Sun, Bai-Wang; Sun, Xiao; Ma, Ning; Wang, Cuifen; Dai, Xiang; Zhang, Lu

doi:10.1111/1462-2920.12895

Cited by 65 publications

(78 citation statements)

References 38 publications

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“…All other variables like diet, age, genetic background, physiological status, and original gut microbiota were controlled. The results show that mice from a sanitary environment had more diverse microbiota and a higher ratio of Bacteroidetes to Firmicutes [17] , which has previously been shown to be good for human health.…”

Section: Research Highlightmentioning

confidence: 75%

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Impact of sanitary living environment on gut microbiota

2018

Precis Med

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The human gut microbiota contributes to human health by aiding functions such as digestion, protection against pathogens, host immunity activation, and central nervous system regulation. Its composition is influenced by many effectors such as diet, genetics, and delivery mode. The hygiene hypothesis suggests that an overly clean living environment increases the incidence of asthma, inflammation, and autism. To test if good hygiene is linked to the composition of the gut microbiota, we raised mice with the same diet in living environments with different levels of hygiene and found that each group had special gut microbiota. Hygiene levels of the living environment influenced early establishment of the human gut microbiota. It is also suspected that a sanitary environment alters the composition of gut microbiota through activating development of the immune system and inoculating the gut with microbial components when some microorganism were killed by oral antibiotics or died due to lack of related nutrition.

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Section: Research Highlightmentioning

confidence: 75%

“…To answer the above question, we raised BALB/c mice under three distinct environmental conditions: a specific pathogen free animal room, a general animal room, and a farmhouse [17] . All other variables like diet, age, genetic background, physiological status, and original gut microbiota were controlled.…”

Section: Research Highlightmentioning

confidence: 99%

Impact of sanitary living environment on gut microbiota

2018

Precis Med

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“…A possible reason for this is the complex farm environment where pollution is more serious. Studies have shown that mice in a farmhouse harbored a significantly more diverse and richer gut microbiota, due to their exposure to unhygienic conditions, compared with mice reared in a specific pathogen-free animal room (Zhou et al 2016). The cultured R. dybowskii is susceptible to disease (Weng et al 2016), and the treatment options are limited.…”

Section: Discussionmentioning

confidence: 99%

Detection and comparative analysis of cutaneous bacterial communities of farmed and wild Rana dybowskii (Amphibia: Anura)

Jia

Liu

Zhang

et al. 2019

The European Zoological Journal

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Rana dybowskii Gunther, 1876 is a dominant amphibian species in northeast China. In order to understand the composition and structure of the cutaneous bacterial communities of farmed and wild R. dybowskii, two experimental groups (farmed and wild) were investigated in this study. Following DNA extraction, the V3-V4 hypervariable region of the 16S rRNA gene was targeted and analyzed by high-throughput sequencing. The cutaneous bacterial community diversity was investigated and compared through analysis of alpha and beta diversity. A total of 524,852 valid sequences and 1,023 operational taxonomic units (OTUs) were obtained from these two experimental groups. The number of shared OTUs was 333, while there were 603 unique OTUs in the farmed group and 87 unique OTUs in the wild group. The Chao, ACE and Shannon indices of the farmed group were significantly higher than those of the wild group (p < 0.05). The composition and abundance of the dominant bacteria at the phylum and genus levels were different. The dominant phyla in the farmed group were Firmicutes, Proteobacteria, Actinobacteria, Chloroflexi, Fusobacteria, Bacteroidetes, and Cyanobacteria. The dominant phyla of the wild group were Proteobacteria, Bacteroidetes, Firmicutes, and Actinobacteria. Furthermore, the alpha and beta diversities of the cutaneous bacterial communities of farmed and wild R. dybowskii exhibited significant differences. This study provides a theoretical basis for comprehensively understanding the composition and abundance of bacteria on the skin of farmed and wild R. dybowskii, which helps to develop its breeding industry and gain economic benefits.

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“…The high-throughput sequencing of 16S rRNA gene demonstrated that the microbiomes of three groups of mice kept in three different environments, including (i) specific pathogen-free animal rooms, (ii) general animal rooms and (iii) farmhouses were different. The enhanced gut microbial diversity, a sign of a healthy microbiome, mostly occurred in the second and third groups whose serum IgE levels were reduced as well (Zhou et al, 2016). The soil components related to a healthier microbiome remain to be identified, and that the soil Streptomycetes can be very attractive candidates.…”

Section: Mucosal Microbiomes and Streptomycetesmentioning

confidence: 99%

“…Their abundance in animals eating directly from nature is more than humans (Wang et al, 2014;Zhang et al, 2015;Rabelo-Fernandez et al, 2018). For example, Zhang et al investigated the rodent's gut microbiome and found that Streptomycetes constitute around 10% of the phylum Actinobacteria that accounted for 11% of rodent's gut microbiome living in a farmhouse (Zhang et al, 2015;Zhou et al, 2016). Streptomycetes were reported in the lower abundance taxa (< 0.5%) in humans (Li et al, 2014;Raymond et al, 2016) whose lifestyle has been significantly changed during the last century.…”

Section: Mucosal Microbiomes and Streptomycetesmentioning

confidence: 99%

Immunosuppressants produced by Streptomyces: evolution, hygiene hypothesis, tumour rapalog resistance and probiotics

Bolourian

Mojtahedi

2018

Environ Microbiol Rep

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Resistance to a drug and the suppression of inflammatory disorders with immunosuppressive drugs might have happened upon exposure to natural compounds during evolution. Streptomycetes are soil bacteria, but they produce therapeutic drugs. They have been reported to be the low-abundant members of mucosal microbiomes with a higher prevalence in nonhumans ingesting soil compared with humans. Their lower abundance in the human microbiome might be the representations of our current hygienic lifestyle. We suggest that the Streptomyces bacteria producing antiproliferative/immunosuppressive compounds (e.g., rapamycin and tacrolimus) contribute to the rapalog resistance of certain mucosal tumours (e.g., colon cancer) and the 'hygiene hypothesis'. If so, the shortage of exposure to these compounds in the current lifestyle might be an underlying reason for the increase of inflammatory diseases, such as inflammatory bowel diseases (IBD). An investigation on adding certain Streptomycetes (e.g., S. hygroscopicus and S. tubercidicus) to the list of probiotics against inflammatory diseases would be an interesting research area in the future.

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Exposure to soil, house dust and decaying plants increases gut microbial diversity and decreases serum immunoglobulin E levels in BALB/c mice

Cited by 65 publications

References 38 publications

Impact of sanitary living environment on gut microbiota

Impact of sanitary living environment on gut microbiota

Detection and comparative analysis of cutaneous bacterial communities of farmed and wild Rana dybowskii (Amphibia: Anura)

Immunosuppressants produced by Streptomyces: evolution, hygiene hypothesis, tumour rapalog resistance and probiotics

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