Exposure to various ambient air pollutants and 9 cardiovascular conditions among individuals with diabetes: A prospective analysis of the UK Biobank

Ma, Yudiyang; Li, Dankang; Xie, Junqing; Hu, Yonghua; Su, Binbin; Tian, Yaohua

doi:10.1016/j.atherosclerosis.2023.02.002

Cited by 4 publications

(1 citation statement)

References 45 publications

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“…Few sex differences were observed between individual air pollutants and ASCVD risk in this study. These results are consistent with previous studies in UK Biobank cohort [ 25 , 39 , 66 – 68 ].…”

Section: Discussionsupporting

confidence: 94%

Sex Associations Between Air Pollution and Estimated Atherosclerotic Cardiovascular Disease Risk Determination

Vallée

2023

Int J Public Health

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Objective: The purpose of this study was to investigate the sex correlations of particulate matters (PM2.5, PM10, PM2.5–10), NO2 and NOx with ASCVD risk in the UK Biobank population.Methods: Among 285,045 participants, pollutants were assessed and correlations between ASCVD risk were stratified by sex and estimated using multiple linear and logistic regressions adjusted for length of time at residence, education, income, physical activity, Townsend deprivation, alcohol, smocking pack years, BMI and rural/urban zone.Results: Males presented higher ASCVD risk than females (8.63% vs. 2.65%, p < 0.001). In males PM2.5, PM10, NO2, and NOx each were associated with an increased ASCVD risk >7.5% in the adjusted logistic models, with ORs [95% CI] for a 10 μg/m3 increase were 2.17 [1.87–2.52], 1.15 [1.06–1.24], 1.06 [1.04–1.08] and 1.05 [1.04–1.06], respectively. In females, the ORs for a 10 μg/m3 increase were 1.55 [1.19–2.05], 1.22 [1.06–1.42], 1.07 [1.03–1.10], and 1.04 [1.02–1.05], respectively. No association was observed in both sexes between ASCVD risk and PM2.5–10.Conclusion: Our findings may suggest the possible actions of air pollutants on ASCVD risk.

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Section: Discussionsupporting

confidence: 94%

Sex Associations Between Air Pollution and Estimated Atherosclerotic Cardiovascular Disease Risk Determination

Vallée

2023

Int J Public Health

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Association between long-term exposure to air pollution and incidence of peripheral artery disease: Evidence from a longitudinal study

Di Blasi,

Nobile,

Settembrini

et al. 2024

European Journal of Internal Medicine

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Assessment of toxicity changes induced by exposure of human cells to lunar dust simulant

Wang,

Lei,

Xue

et al. 2024

Sci Rep

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The toxicity of lunar dust (LD) to astronauts' health has been confirmed in the Apollo missions and subsequent biological experiments. Therefore, it is crucial to understand the biological toxicity of lunar dust for future human missions to the Moon. In this study, we exposed human lung epithelial cells (BEAS-2B) and peripheral blood B lymphocytes (AHH-1) to varying concentrations (0, 500, 1000, and 1500 μg/ml) of a lunar dust simulant (LDS) called CLDS-i for 24 and 48 h. The results provided the following key findings: (1) LDS induction of cell damage occurred through oxidative stress, with the levels of reactive oxygen species (ROS) in BEAS-2B cells being dependent on the duration of exposure. (2) Necrosis and early apoptosis were observed in BEAS-2B cells and AHH-1 cells, respectively. In addition, both cells showed lysosomal damage. (3) Genes CXCL1, SPP1, CSF2, MMP1, and POSTN are implicated in immune response and cytoskeletal arrangement regulation in BEAS-2B cells. Considering the similarities in composition and properties between CLDS-i and real lunar dust, our findings not only enhance the understanding of LDS toxicity, but also contribute to a better comprehension of the genomic alterations and molecular mechanisms underlying cellular toxicity induced by LD. These insights will contribute to the development of a biotoxicology framework aimed at safeguarding the health of astronauts and, consequently, facilitating future human missions to the Moon.

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Exposure to various ambient air pollutants and 9 cardiovascular conditions among individuals with diabetes: A prospective analysis of the UK Biobank

Cited by 4 publications

References 45 publications

Sex Associations Between Air Pollution and Estimated Atherosclerotic Cardiovascular Disease Risk Determination

Sex Associations Between Air Pollution and Estimated Atherosclerotic Cardiovascular Disease Risk Determination

Association between long-term exposure to air pollution and incidence of peripheral artery disease: Evidence from a longitudinal study

Assessment of toxicity changes induced by exposure of human cells to lunar dust simulant

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