Exposure to visible mould or dampness at home and sleep problems in children: Results from the LISAplus study

Tiesler, Carla M. T.; Thiering, Elisabeth; Tischer, Christina; Lehmann, Irina; Schaaf, Beate; Berg, Andrea von; Heinrich, Joachim

doi:10.1016/j.envres.2014.11.023

Cited by 33 publications

(20 citation statements)

References 23 publications

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“…High concentrations of dust mite allergen are found on beds and may be a source of exposure during sleep. In children with AD from the German LISAplus cohort, exposure to mold or visible dampness was also associated with increased risk of sleep problems, including difficulty falling asleep, difficulty staying asleep, and decreased overall sleep time [ 66 ]. Currently, there is a lack of studies examining the impact of environmental factors on sleep in adults with AD.…”

Section: Discussionmentioning

confidence: 99%

Frequency and Management of Sleep Disturbance in Adults with Atopic Dermatitis: A Systematic Review

Jeon

Yan

Nakamura

et al. 2017

Dermatol Ther (Heidelb)

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IntroductionIntense nocturnal pruritus as well as the complex pathophysiology of atopic dermatitis (AD) can severely affect sleep and become a major factor in negatively impacting quality of life in adults. However, much of the literature on sleep disturbance in AD patients is on the pediatric population, and it is not well studied in adults. Furthermore, limited studies are available to guide effective management of sleep disturbance in AD in general. We review the literature to present the studies that have investigated the relationship between AD and its effect on sleep in adults and provide an approach for clinicians caring for this population.MethodsA systematic literature search was conducted through the PubMed and EMBASE databases using the search terms “atopic dermatitis” OR “eczema” AND “sleep.” The articles generated by the search and their references were reviewed.ResultsA high prevalence of sleep disturbance is experienced by adults with AD. The likelihood of sleep disturbance is much higher in patients with AD compared to those without AD. Sleep disturbance appears to worsen with AD severity. Pruritus and scratching appear to be large contributors to sleep disturbance in adult patients with AD.ConclusionIt is important that clinicians evaluate the severity of AD and ask general questions about itching, sleep, impact on daily activities, and persistence of disease during each patient visit and follow-up with the complaint of sleep disturbance. Management of sleep disturbance in AD should focus on adequate disease control of AD as well as possible medical interventions to help improve sleep. The pathophysiology of sleep disturbance in AD is extremely complex, and further research is needed to better understand the interplay of the immune system, circadian rhythm, and environmental factors implicated in both AD and sleep.

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Section: Discussionmentioning

confidence: 99%

Frequency and Management of Sleep Disturbance in Adults with Atopic Dermatitis: A Systematic Review

Jeon

Yan

Nakamura

et al. 2017

Dermatol Ther (Heidelb)

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“…In our study, wall moisture measurements in LRs and BRs were positively correlated, but BRs were damper In children, visible mold or dampness in a home also has been associated with sleep problems (Tiesler et al, 2014). Infants may spend even more time than other family members in their BRs, and the finding that BR walls were damper than LR walls suggested potentially greater exposure of these infants to dampness-related agents in the first year of life.…”

Section: Discussionmentioning

confidence: 41%

“…() postulated that their finding of an association between lung function and damp spots only in BRs was due to the longer time people spend sleeping and the smaller size and poorer ventilation of BRs relative to other parts of homes. In children, visible mold or dampness in a home also has been associated with sleep problems (Tiesler et al., ). Infants may spend even more time than other family members in their BRs, and the finding that BR walls were damper than LR walls suggested potentially greater exposure of these infants to dampness‐related agents in the first year of life.…”

Section: Discussionmentioning

confidence: 99%

Higher measured moisture in California homes with qualitative evidence of dampness

et al. 2016

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Relationships between measured moisture and qualitative dampness indicators (mold odor, visible mold, visible water damage, or peeling paint) were evaluated using data collected from California homes in a prospective birth cohort study when the infants were 6 or 12 months of age (737 home visits). For repeated visits, agreement between observation of the presence/ absence of each qualitative indicator at both visits was high (71-87%, P < 0.0001). Among individual indicators, musty odor and visible mold were most strongly correlated with elevated moisture readings. Measured moisture differed significantly between repeated visits in opposite seasons (P < 0.0001), and dampness increased with the number of indicators in a home. Linear mixedeffect models showed that 10-unit increases in maximum measured moisture were associated with the presence of 0.5 additional dampness indicators (P < 0.001). Bedroom (BR) walls were damper than living room (LR) walls in the same homes (P < 0.0001), although both average and maximum readings were positively correlated across room type (r = 0.75 and 0.67, respectively, both P < 0.0001). Exterior walls were significantly damper than interior walls (P < 0.0001 in both LRs and BRs), but no differences were observed between maximum wall readings and measurements at either window corners or sites of suspected dampness. Practical ImplicationsThe more indicators of dampness or mold present in a home (especially musty odor and visible mold), the damper the walls were likely to be. In our study, the consistency of dampness indicators over time suggests that one-time, qualitative assessments of dampness and mold have value in identifying moisture problems. However, the seasonal variation seen in measured wall moisture suggests that quantitative measurements repeated at different times of year may be necessary to identify transient moisture problems. Therefore, moisture measurements may be most informative when assessed along with dampness indicators, some of which consistently have been associated with increased risks of respiratory disease, for example, mold odor, visible mold, and water damage.

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“…The relationship between P. crustosum and insomnia could be explained by other studies which have found that mold or dampness was related to a high prevalence of sleep problems [62,63]. For the four symptoms (cough, fever, headache and insomnia) observed with P. crustosum, the median airborne concentrations were observed at higher extents when the symptoms were reported.…”

Section: Discussionmentioning

confidence: 73%

Relationships between Exposure to Bioaerosols, Moldy Surface and Symptoms in French Mold-Damaged Homes

et al. 2020

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Air quality in homes is a major concern in Europe, where people spend most of their time indoors. According to the World Health Organization, numerous houses are subject to dampness that can lead to mold growth, with associated health and economic consequences. Our goal was to characterize the human exposure to bioaerosols in French mold-damaged houses but also to study the effects of these bioaerosols as suffered by the inhabitants of these houses. A global approach including both field study and laboratory experimentation was used to investigate 48 mold-damaged homes. Among a wide fungal diversity, 101 viable species, Aspergillus versicolor, Penicillium chrysogenum and P. crustosum were observed as recurrent species and could be used as microbial indicators of indoor air quality. Statistical analyses highlighted a relationship between the concentrations of these recurrent molds and the levels of surface contamination by molds in homes. Fever, cough, dyspnea, flu-like symptoms were observed with several fungal strains (A. versicolor, P. chrysogenum and P. crustosum) or in relation to moldy odor. Relationships between particles of 2 to 15 µm diameter and headaches and dizziness were also observed. In our study, we identified a cutaneous effect (itching) in relationship to the airborne concentration of A. versicolor.

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Exposure to visible mould or dampness at home and sleep problems in children: Results from the LISAplus study

Abstract: Our data suggests that visible mould or dampness at home might negatively influence sleep in children. The influence of allergic rhinoconjunctivitis on this association needs to be investigated in future studies.

Cited by 33 publications

References 23 publications

Frequency and Management of Sleep Disturbance in Adults with Atopic Dermatitis: A Systematic Review

Frequency and Management of Sleep Disturbance in Adults with Atopic Dermatitis: A Systematic Review

Higher measured moisture in California homes with qualitative evidence of dampness

Relationships between Exposure to Bioaerosols, Moldy Surface and Symptoms in French Mold-Damaged Homes

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