Exposure to waterborne 4-tert-octylphenol induces vitellogenin synthesis and disrupts testis morphology in the South American freshwater fish Cichlasoma dimerus (Teleostei, Perciformes)

Vázquez, Graciela Rey; Meijide, F.; Cuña, Rodrigo Hernán Da; Nostro, Fabiana Laura Lo; Piazza, Yanina Grisel; Babay, Paola Alejandra; Trudeau, Vance L.; Maggese, M.C.; Guerrero, G.A.

doi:10.1016/j.cbpc.2009.05.012

Cited by 37 publications

(33 citation statements)

References 69 publications

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“…In this context, this benthic species can be considered a useful sentinel to evaluate the presence of xeno‐oestrogens in the aquatic environment. Indeed, to date, the oestrogenic activity of EDCs has mostly been investigated in planktonic species (Ruggeri et al , 2008; Bickley et al , 2009; Rey Vázquez et al , 2009). Further studies are needed to better define the role of VTG as a biomarker: recent investigations have shown that VTG could be involved in other major physiological responses, such as immune response (Glinski & Jarosz, 2000; Zhang et al , 2005; Shi et al , 2006; Matozzo et al , 2008).…”

Section: Discussionmentioning

confidence: 99%

“…In such animals, treatment with NP induces, other than VTG synthesis, a significant reduction in the gonado-somatic index (Sumpter & Jobling, 1995;Jobling et al, 1996;Korsgaard and Pedersen, 1998;Christensen et al, 1999), alterations in gametogenesis (Gimeno et al, 1998;Christensen et al, 1999;Van Den Belt et al, 2002;Weber et al, 2003), an increase in apoptotic and necrotic testicular cells (Gimeno et al, 1998;Christensen et al, 1999;Weber et al, 2002) and production of ovo-testis (Gray et al, 1999). Histological alterations were also reported in the liver (Folmar et al, 2001;Zaroogian et al, 2001;Rey Vázquez et al, 2009) and kidney (Folmar et al, 2001;Zaroogian et al, 2001;Vaccaro et al, 2005). Furthermore, although the liver is the site responsible for VTG synthesis in other fishes, namely medaka Oryzias latipes (Temminck & Schlegel 1846) and rare minnow Gobiocypris rarus Ye & Fu 1983, NP-induced VTG was also recorded in the testis and kidney (Kobayashi et al, 2005;Zha et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Effects of nonylphenol on vitellogenin synthesis in adult males of the spotted ray Torpedo marmorata

Giudice

Prisco

Agnese

et al. 2012

Journal of Fish Biology

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The aim of this investigation was to assess the effects of nonylphenol (NP), an oestrogen-like environmental pollutant, on the vitellogenin (VTG) synthesis in adult males of the aplacental viviparous cartilaginous fish Torpedo marmorata. The VTG recovery in males is considered a biomarker of xeno-oestrogenic pollution as this lipophosphoglycoprotein is physiologically induced by oestrogens only in females of oviparous and ovoviparous vertebrates. Using in situ hybridization and immunohistochemistry, T. marmorata males injected with nonylphenol showed the presence of VTG in the liver and the kidney. In particular, vtg messenger (m)RNA and VTG protein were expressed in the liver, whereas in the kidney cells only the presence of VTG was recorded. By contrast, no expression for VTG was detected in the testis. These results demonstrate that in T. marmorata NP induces the expression of vtg only in the liver; the presence of VTG in the kidney and its absence in the testis are discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of nonylphenol on vitellogenin synthesis in adult males of the spotted ray Torpedo marmorata

Giudice

Prisco

Agnese

et al. 2012

Journal of Fish Biology

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“…An example is the alkylphenolic pollutant, 4- tert -octylphenol (OP) (Sharma et al, 2009; Ying et al, 2002) that is detected in the plasma and adipose tissue within human populations (Calafat et al, 2008; Inoue et al, 2000; Lopez-Espinosa et al, 2009; Ying et al, 2002). Across a wider range of vertebrate species the observed biological effects of OP exposure are multifold and may include altered gene and/or protein expression in gonadal and pituitary tissues (Lee et al, 2006; Majdic et al, 1997; Mayer et al, 2003; Rhee et al, 2009), abnormal steroid production (Mikkila et al, 2006; Myllymaki et al, 2005b), sperm abnormalities, changes in testicular function (Herath et al, 2004; Kinnberg and Toft, 2003; Rey et al, 2009;) Blake et al, 2004), and impaired sexual differentiation and fertility (Rasmussen et al, 2002; Seki et al, 2003; Karels et al, 2003). Thus, investigation of the biological outcome following treatment of a sentinel species with OP represents a useful model for exposure to estrogenic substances prevalent within the environment.…”

Section: Introductionmentioning

confidence: 99%

Estrogenic environmental contaminants alter the mRNA abundance profiles of genes involved in gonadal differentiation of the American bullfrog

Wolff

Veldhoen

Helbing

et al. 2015

Science of The Total Environment

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Wildlife and human populations are exposed to anthropogenic mixtures of chemicals in the environment that may adversely influence normal reproductive function and development. We determined the effects of exposure to estrogenic chemicals and wastewater effluent (WWE) on developing gonads of the American bullfrog, Rana (Lithobates) catesbeiana, a species whose widespread distribution make it an ideal model for environmental monitoring for endocrine effects of chemical contaminants. Premetamorphic bullfrog tadpoles were exposed to treatment vehicle, 17β-estradiol (E2; 10−9 M) or 4-tert-octylphenol (OP; 10−9 M, 10−8 M, and 10−7 M). Additionally, gonadal differentiation was evaluated in bullfrog tadpoles from a WWE-containing site versus those from a reference location receiving no WWE. In both studies, phenotypic sex, steroidogenic factor-1 (nr5a1), and aromatase (cyp19a1) mRNA levels using quantitative real-time PCR were determined. Exposure to E2 or OP did not alter sex ratios. In controls, both nr5a1 and cyp19a1 transcript levels exhibited sexual dimorphism, with males demonstrating higher levels of nr5a1 and females greater abundance of cyp19a1. However, E2 exposure increased cyp19a1 mRNA abundance in testes and decreased levels in ovaries, eliminating the sexual dimorphism observed in controls. E2-exposed males exhibited increased nr5a1 transcript levels in the testes compared to controls, while females demonstrated no E2 effect. OP treatment had no effect on female cyp19a1 mRNA abundance, but exposure to 10−7 M OP increased testicular transcript levels. Treatment with 10−9 and 10−8 M OP, but not 10−7 M, resulted in decreased abundance of nr5a1 transcript in both ovaries and testes. Animals from the field had sexually dimorphic gonadal levels of cyp19a1, but both sexes from the WWE site exhibited elevated cyp19a1 transcript abundance compared to the reference location. Individual chemical compounds and anthropogenic wastewater effluent dispersed within the environment influence the levels of gonadal mRNA encoding key proteins involved in gonadal differentiation.

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“…O ERA é definido como procedimentos, utilizando metodologias científicas, pelo qual o provável ou atual efeito adverso dos poluentes ou outras atividades antrópicas nos ecossistemas e seus componentes são estimados com um grau conhecido de certeza (Depledge e Fossi, 1994) (Nishi et al, 2002). Muitos dos desreguladores químicos endócrinos podem apresentar efeitos semelhantes aos hormônios estrógenos, sendo então referidos como agentes estrogênicos (Vázquez et al, 2009). Nos últimos anos, tem havido um significativo esforço para demonstrar os efeitos dos xenobióticos, que são compostos químicos estranhos ao sistema biológico, no controle fisiológico da reprodução dos animais selvagens (Vázquez et al, 2009) pela enzima 20β-hidroxi-esteroide-desidrogenase (20βHSD).…”

Section: Histórico E Definiçõesunclassified

“…Muitos dos desreguladores químicos endócrinos podem apresentar efeitos semelhantes aos hormônios estrógenos, sendo então referidos como agentes estrogênicos (Vázquez et al, 2009). Nos últimos anos, tem havido um significativo esforço para demonstrar os efeitos dos xenobióticos, que são compostos químicos estranhos ao sistema biológico, no controle fisiológico da reprodução dos animais selvagens (Vázquez et al, 2009) pela enzima 20β-hidroxi-esteroide-desidrogenase (20βHSD). O 17α20βP-DHP é o hormônio efetivo da maturação final dos oócitos e ovulação na maioria dos teleósteos (Zohar et al, 2010).…”

Section: Histórico E Definiçõesunclassified

Influência antrópica no ambiente aquático sobre os processos fisiológicos associados à maturação oocitária em peixes teleósteos

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Exposure to waterborne 4-tert-octylphenol induces vitellogenin synthesis and disrupts testis morphology in the South American freshwater fish Cichlasoma dimerus (Teleostei, Perciformes)

Cited by 37 publications

References 69 publications

Effects of nonylphenol on vitellogenin synthesis in adult males of the spotted ray Torpedo marmorata

Effects of nonylphenol on vitellogenin synthesis in adult males of the spotted ray Torpedo marmorata

Estrogenic environmental contaminants alter the mRNA abundance profiles of genes involved in gonadal differentiation of the American bullfrog

Influência antrópica no ambiente aquático sobre os processos fisiológicos associados à maturação oocitária em peixes teleósteos

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