Expresión de Citoqueratina 5 y Calretinina en el carcinoma renal de células claras

Mouteira, P. Cid; Ortiz-Rey, J.A.; María, C. Gómez de; Fraile, P. San Miguel; Barroso, Agustín; Parcero, B. Regueiro; Badiola, I. Antón

doi:10.1016/s0210-4806(06)73460-x

Cited by 4 publications

(1 citation statement)

References 15 publications

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“…Finally, the sample was stained using hematoxylin–eosin (H-E) and examined under an optical microscope (Leica DM 2000). To confirm the diagnosis based on observations made during the tissue biopsy histopathology, we carried out immunostaining using calretinin (mesothelioma sensitive marker ( 13 )), mesothelin (tumor differentiation antigen overexpressed in neoplasms ( 14 )), and cytokeratin 5/6 (CK 5/6), which are proteins with expression in stratified epithelial layers, mesothelial cells, and proliferating squamous epithelium ( 15 ). The tissue sections were then incubated with antibodies against calretinin (mouse, clone H5, 1: 100, Diagnostic Biosystem), mesothelin (human, clone 5B2, 1: 50, Thermo Fisher), and cytokeratin 5/6 (mouse, clone D516 B4, 1:100, Diagnostic Biosystem).…”

Section: Casementioning

confidence: 99%

Case report: Abdominal mesothelioma in Atelerix albiventris

Troncoso,

Brown,

Isla

et al. 2024

Front. Vet. Sci.

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Hedgehogs, as exotic species, are more susceptible to various neoplastic conditions affecting diverse bodily systems, particularly the tegumentary, hemolymphatic, and digestive systems. Among these conditions, epithelial tumors are the most prevalent, followed by round cell tumors and mesenchymal tumors. A striking characteristic is the malignant nature of over 8% of these tumors, leading to a generally unfavorable prognosis. This study aims to present a unique case involving a 2.5 year-old male African pygmy hedgehog in Concepción, Biobío District, Chile, diagnosed with a mesenchymal neoplasia originating from mesothelial cells. The hedgehog presented to the veterinary clinic with acute abdominal pain, prompting ultrasound imaging, and comprehensive cytological, histopathological, and immunohistochemical analyses. During abdominal ultrasound, a mass was observed, and its cytological examination revealed the presence of malignant cells. The histopathological examination unveiled a diffuse mesothelial cell tissue interwoven with abundant fibrous tissue and small cysts containing serous fluid, all enveloped by flattened or cuboidal cells of mesothelial origin. Immunohistochemistry further confirmed the diagnosis, demonstrating positive immunostaining for calretinin and mesothelin markers, corroborating the diagnosis of fibrous malignant peritoneal mesothelioma. This case highlights the complexity of neoplastic conditions in hedgehogs and emphasizes the importance of multimodal diagnostic approaches for accurate identification and understanding of these rare diseases.

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Section: Casementioning

confidence: 99%