Expressão de Proteína-1 Relacionada a Receptor de Lipoproteína de Baixa Densidade (LRP1) em Monócito em Correlação com EIMC em Pacientes Mexicanos Hipertensos

Gamboa, Ricardo; Jaramillo-Estrella, María José; Martínez-Alvarado, María del Rocio; Soto, Marí­a Elena; Torres-Paz, Yazmín Estela; Gonzalo-Calvo, David de; Valle-Mondragón, Leonardo Del; López‐Marure, Rebeca; Llorente‐Cortés, Vicenta; Huesca-Gómez, Claudia

doi:10.36660/abc.20190535

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…Proteins were analyzed by Western blot analysis as previously described ( 16 ). Blots were incubated with antibodies against human UCP1 (polyclonal antibody Abcam ab10983, dilution 1:500), human UCP2 (polyclonal antibody Abcam ab67241, dilution 1:500), and human UCP3 (polyclonal antibody Abcam 10985, dilution 1:1000).…”

Section: Methodsmentioning

confidence: 99%

Expressions of mRNA and encoded proteins of mitochondrial uncoupling protein genes (UCP1, UCP2, and UCP3) in epicardial and mediastinal adipose tissue and associations with coronary artery disease

Huesca-Gómez

Torres-Paz

Fuentevilla-Álvarez

et al. 2023

Archives of Endocrinology and Metabolism

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Objective: To evaluate the expression of UCP1, UCP2, and UCP3 mRNA and encoded proteins in epicardial and mediastinal adipose tissues in patients with coronary artery disease (CAD). Subjects and methods: We studied 60 patients with CAD and 106 patients undergoing valve replacement surgery (controls). Expression levels of UCP1, UCP2, and UCP3 mRNA and encoded proteins were measured by quantitative real-time PCR and Western blot analysis, respectively. Results: We found increased UCP1, UCP2, and UCP3 mRNA levels in the epicardial adipose tissue in the CAD versus the control group, and higher UCP1 and UCP3 mRNA expression in the epicardial compared with the mediastinal tissue in the CAD group. There was also increased expression of UCP1 protein in the epicardial tissue and UCP2 protein in the mediastinum tissue in patients with CAD. Finally, UCP1 expression was associated with levels of fasting plasma glucose, and UCP3 expression was associated with levels of high-density lipoprotein cholesterol and low-density cholesterol in the epicardial tissue. Conclusions: Our study supports the hypothesis that higher mRNA expression by UCP genes in the epicardial adipose tissue could be a protective mechanism against the production of reactive oxygen species and may guard the myocardium against damage. Thus, UCP levels are essential to maintain the adaptive phase of cardiac injury in the presence of metabolic disorders.

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Section: Methodsmentioning

confidence: 99%

Expressions of mRNA and encoded proteins of mitochondrial uncoupling protein genes (UCP1, UCP2, and UCP3) in epicardial and mediastinal adipose tissue and associations with coronary artery disease

Huesca-Gómez

Torres-Paz

Fuentevilla-Álvarez

et al. 2023

Archives of Endocrinology and Metabolism

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“…Furthermore, the combination of hsa-miRNA-5589-5p and LRPAP1 may have diagnostic utility for hypertension. To explore the potential upstream regulation of these three key genes, the modulatory interaction between transcription factors and LRPAP1, ARID3A, and KIAA0513 was investigated (107)(108)(109)(110). Among the 123 mRNAs associated with hypertension, only the CEBPA transcription factor gene was identified.…”

Section: Role Of Mirnas and Epigenetics In Hypertension Pathogenesis:...mentioning

confidence: 99%

Epigenetics of hypertension as a risk factor for the development of coronary artery disease in type 2 diabetes mellitus

Karabaeva,

Vochshenkova,

Mussin

et al. 2024

Front. Endocrinol.

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Hypertension, a multifaceted cardiovascular disorder influenced by genetic, epigenetic, and environmental factors, poses a significant risk for the development of coronary artery disease (CAD) in individuals with type 2 diabetes mellitus (T2DM). Epigenetic alterations, particularly in histone modifications, DNA methylation, and microRNAs, play a pivotal role in unraveling the complex molecular underpinnings of blood pressure regulation. This review emphasizes the crucial interplay between epigenetic attributes and hypertension, shedding light on the prominence of DNA methylation, both globally and at the gene-specific level, in essential hypertension. Additionally, histone modifications, including acetylation and methylation, emerge as essential epigenetic markers linked to hypertension. Furthermore, microRNAs exert regulatory influence on blood pressure homeostasis, targeting key genes within the aldosterone and renin-angiotensin pathways. Understanding the intricate crosstalk between genetics and epigenetics in hypertension is particularly pertinent in the context of its interaction with T2DM, where hypertension serves as a notable risk factor for the development of CAD. These findings not only contribute to the comprehensive elucidation of essential hypertension but also offer promising avenues for innovative strategies in the prevention and treatment of cardiovascular complications, especially in the context of T2DM.

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Integrated Analysis of miRNA and mRNA Regulation Network in Hypertension

et al. 2023

Biochem Genet

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Expressão de Proteína-1 Relacionada a Receptor de Lipoproteína de Baixa Densidade (LRP1) em Monócito em Correlação com EIMC em Pacientes Mexicanos Hipertensos

Cited by 4 publications

References 36 publications

Expressions of mRNA and encoded proteins of mitochondrial uncoupling protein genes (UCP1, UCP2, and UCP3) in epicardial and mediastinal adipose tissue and associations with coronary artery disease

Expressions of mRNA and encoded proteins of mitochondrial uncoupling protein genes (UCP1, UCP2, and UCP3) in epicardial and mediastinal adipose tissue and associations with coronary artery disease

Epigenetics of hypertension as a risk factor for the development of coronary artery disease in type 2 diabetes mellitus

Integrated Analysis of miRNA and mRNA Regulation Network in Hypertension

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