Expresser phenotype determines ABO(H) blood group antigen loading on platelets and von Willebrand factor

O'Donghaile, D.; Jenkins, Patrick; McGrath, Rachel T.; Preston, Lisa; Field, Stephen; Ward, Soracha E.; O’Sullivan, Jamie M.; O’Donnell, James S.

doi:10.1038/s41598-020-75462-2

Cited by 8 publications

(6 citation statements)

References 42 publications

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“…It follows that more extensive glycosylation of VWF found in group A secretors but lacking in group O secretors would also result in higher circulating levels of high molecular weight VWF multimers in Group A. In addition, it has been observed that ABO genotype is a major determinant of ABO expression on platelets with homozygous A giving the highest expression [39]; ABO expression on platelets determines how they adhere to VWF captured by exposed collagen in the endothelium [40], with non-group O platelets adhering more strongly than group O. This leads to increased and more stable thrombus production in non-group O individuals.…”

Section: Discussionmentioning

confidence: 99%

Blood group type A secretors are associated with a higher risk of COVID‐19 cardiovascular disease complications

Mankelow

Singleton

Moura

et al. 2021

eJHaem

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The SARS-CoV-2 virus causes COVID-19, an infection capable of causing severe disease and death but which can also be asymptomatic or oligosymptomatic. We investigated whether ABO blood group or secretor status was associated with COVID-19 severity. We investigated secretor status because expression of ABO glycans on secreted proteins and non-erythroid cells are controlled by a fucosyltransferase (FUT2), and inactivating FUT2 mutations result in a non-secretor phenotype which protects against some viral infections. Data combined from healthcare records and our own laboratory tests (n = 275) of hospitalized SARS-CoV-2 polymerase chain reaction positive patients confirmed higher than expected numbers of blood group A individuals compared to O (RR = 1.24, CI 95% [1.05, 1.47], p = 0.0111). There was also a significant association between group A and COVID-19-related cardiovascular complications (RR = 2.56, CI 95% [1.43, 4.55], p = 0.0011) which is independent of gender.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

Blood group type A secretors are associated with a higher risk of COVID‐19 cardiovascular disease complications

Mankelow

Singleton

Moura

et al. 2021

eJHaem

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“…Therefore, the association of ABO polymorphisms with ACS observed in this study may be mediated by microbiota. Second, A, B, and H carbohydrates are expressed on different glycoproteins on platelet surfaces and are also present on glycans of the von Willebrand factor [ 34 ]. Consequently, ABO group determinants may affect the thrombotic process during a coronary event.…”

Section: Discussionmentioning

confidence: 99%

“…Even if controversial, our data and previous reports suggest an association of the rs579459 T/C, rs8176746 T/G, and rs8176740 A/T SNPs with cardiovascular events. The potential mechanisms that could explain the statistical association of ABO polymorphisms with cardiovascular outcomes may involve the gut microbiota and platelets aggregation [8,[29][30][31][32][33][34]. First, A, B, and H carbohydrates are expressed in different tissues and may also be secreted as soluble molecules in certain individuals.…”

Section: Discussionmentioning

confidence: 99%

ABO gene polymorphisms are associated with acute coronary syndrome and with plasma concentration of HDL-cholesterol and triglycerides

Vargas‐Alarcón¹,

Pérez-Méndez²,

Posadas-Sánchez³

et al. 2023

Biomol Biomed

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The role of ABO gene polymorphisms in acute coronary syndrome (ACS) and lipid metabolism is increasingly recognized. We investigated whether ABO gene polymorphisms are significantly associated with ACS and the plasma lipid profile. Six ABO gene polymorphisms (rs651007 T/C, rs579459 T/C, rs495928 T/C, rs8176746 T/G, rs8176740 A/T, and rs512770 T/C) were determined by 5’exonuclease TaqMan assays in 611 patients with ACS and 676 healthy controls. The results demonstrated that the rs8176746 T allele was associated with a lower risk of ACS under the co-dominant, dominant, recessive, over-dominant, and additive models (P=0.0004, P=0.0002, P=0.039, P=0.0009, and P=0.0001, respectively). Furthermore, under co-dominant, dominant, and additive models, the rs8176740 A allele was associated with a lower risk of ACS (P=0.041, P=0.022, and P=0.039, respectively). On the other hand, the rs579459 C allele was associated with a lower risk of ACS under the dominant, over-dominant, and additive models (P=0.025, P=0.035, and P=0.037, respectively). In a subanalysis performed with the control group, rs8176746 T and rs8176740 A alleles were associated with low systolic blood pressure and with both high HDL-C and low triglyceride plasma concentrations, respectively. In conclusion, ABO gene polymorphisms were associated with a lower risk of ACS, and lower systolic blood pressure and plasma lipid levels, suggesting a causal relationship between ABO blood groups and the incidence of ACS.

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“…The ABO blood group antigens are the most studied and genetically polymorphic blood group system among the over 300 different blood group antigens identified on the membranes of red blood cells (RBCs) [1]. Although the A, B, and H determinants, which make up the ABO blood group system, are typically thought to be found on red blood cells, they may also be expressed on a range of different cell types, including platelets, von Willebrand factor (vWF), and endothelial cells [2]. The ABO blood group phenotype is regarded as one important determinant of the wide variation of plasma vWF antigen (vWF: Ag) levels in normal individuals, even though other contributing factors such as age, stress, medications, and hormones have been identified [3,4].…”

Section: Introductionmentioning

confidence: 99%

Plasma von Willebrand Factor Antigen Levels and Its Relation with ABO Blood Group, Age and Sex

et al. 2022

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Background: The ABO blood antigens may influence the levels of vWF: Ag and put individuals at risk of coagulopathies. This study assessed the plasma vWF: Ag and its relation with ABO blood antigens among healthy adults in northern Ghana. Methods: This cross-sectional study recruited 84 blood donors, aged 18–50 years, at Tamale Teaching Hospital. Blood groups were determined using the standard tube method, and a complete blood count was measured with an automated haematology analyzer. Sandwich ELISA was used to assess plasma vWF: Ag levels. The data obtained were analyzed using SPSS version 22. Results: The frequencies of O, A, B, and AB blood groups were 34 (40.5%), 25 (29.8%), 20 (23.8%), and 5 (6.0%), respectively. vWF: Ag levels were higher among the non-O than group O individuals (p = 0.008). Plasma vWF: Ag levels were lower in group O compared to AB (p = 0.015) and A (p = 0.013) individuals. Males had higher vWF: Ag levels than females (p = 0.002). A moderately positive correlation was observed between age and vWF levels (r = 0.497, p<0.001). Blood group O participants had lower absolute neutrophil counts (p = 0.039), but higher RDW-SD (p = 0.045). Conclusion: The predominant blood group was O, followed by other groups in the order: O>A>B>AB. Plasma vWF: Ag levels were higher in non-group O compared with group O individuals. Males had higher vWF: Ag levels, and a positive correlation between age and vWF: Ag was observed. Again, blood group O participants had lower neutrophil counts, but higher RDW-SD. The relationship between ABO blood phenotypes and plasma vWF: Ag should be considered in clinical practice. The establishment of separate reference intervals of vWF: Ag for the various phenotypes of ABO is recommended. Also, the study recommends further multicenter studies to assess the link between ABO phenotypes and all the endothelial cell parameters. Doi: 10.28991/SciMedJ-2022-04-02-02 Full Text: PDF

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Expresser phenotype determines ABO(H) blood group antigen loading on platelets and von Willebrand factor

Cited by 8 publications

References 42 publications

Blood group type A secretors are associated with a higher risk of COVID‐19 cardiovascular disease complications

Blood group type A secretors are associated with a higher risk of COVID‐19 cardiovascular disease complications

ABO gene polymorphisms are associated with acute coronary syndrome and with plasma concentration of HDL-cholesterol and triglycerides

Plasma von Willebrand Factor Antigen Levels and Its Relation with ABO Blood Group, Age and Sex

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