Expression and actions of corticotropin-releasing factor/diuretic hormone-like peptide (CDLP) and teneurin C-terminal associated peptide (TCAP) in the vase tunicate, Ciona intestinalis : Antagonism of the feeding response

Hsieh, Alan; Hsieh, Adam H.; Almeida, Reuben De; Lovejoy, Sabine R.; Lovejoy, David A.

doi:10.1016/j.ygcen.2016.06.015

Cited by 14 publications

(15 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, evolutionary analysis of the TCAP peptide revealed that it predates insulin, which suggests its metabolic functions are highly conserved (Hogg et al, 2018). D’Aquila et al (2017) showed that TCAP-1 treatment increased contractile behaviors in C. intestinalis , which is an energy dependent behavior. This suggests that TCAP can increase the energy production and metabolism in primitive species, further supporting the notion that TCAP has conserved functions in metabolism.…”

Section: Teneurin C-terminal Associated Peptides (Tcap)mentioning

confidence: 98%

“…TCAP can be independently transcribed or be cleaved from teneurin as a peptide, suggesting it has functional independence from its pro-protein teneurin (Qian et al, 2004; Chand et al, 2013a). Several TCAP peptides homologs (TCAP-1-4) have been identified at the extracellular end of teneurins in a number of species (Qian et al, 2004; Colacci et al, 2005; Wang et al, 2005; Lovejoy et al, 2006; Tan et al, 2011; Chand et al, 2013a, 2014; D’Aquila et al, 2017). TCAP peptides are well conserved across animal taxa (Lovejoy et al, 2009), including teleost fishes (Figure 2A,B).…”

Section: Teneurin C-terminal Associated Peptides (Tcap)mentioning

confidence: 99%

See 1 more Smart Citation

Teneurins and Teneurin C-Terminal Associated Peptide (TCAP) in Metabolism: What’s Known in Fish?

et al. 2019

View full text Add to dashboard Cite

Teneurins have well established roles in function and maintenance of the central nervous systems of vertebrates. In addition, teneurin c-terminal associated peptide (TCAP), a bioactive peptide found on the c-terminal portion of teneurins, has been shown to regulate glucose metabolism. Although, the majority of research conducted on the actions of teneurins and TCAPs has strictly focused on neurological systems in rodents, TCAP was first identified in rainbow trout after screening trout hypothalamic cDNA. This suggests a conserved functional role of TCAP across vertebrates, however, the current depth of literature on teneurins and TCAPs in fish is limited. In addition, the overall function of TCAP in regulating metabolism is unclear. This review will highlight work that has been conducted specifically in fish species in relation to the teneurin system and metabolism in order to identify areas of research that are needed for future work.

show abstract

Section: Teneurin C-terminal Associated Peptides (Tcap)mentioning

confidence: 98%

Section: Teneurin C-terminal Associated Peptides (Tcap)mentioning

confidence: 99%

Teneurins and Teneurin C-Terminal Associated Peptide (TCAP) in Metabolism: What’s Known in Fish?

et al. 2019

View full text Add to dashboard Cite

show abstract

“…A 13 kDa band was identified by Western blot, which could correspond to either a furin cleavage product or the full-length translation product of the TCAP-1 mRNA (Chand et al, 2013a). A smaller 5 kDa band was shown in protein extracts from the vase tunicate, Ciona intestinalis , which could represent a soluble form of its 39-amino acid TCAP (Colacci et al, 2015; D’Aquila et al, 2017).…”

Section: Evidence Of Tcap As a Small Soluble Peptidementioning

confidence: 99%

Activity of the Carboxy-Terminal Peptide Region of the Teneurins and Its Role in Neuronal Function and Behavior in Mammals

et al. 2019

Self Cite

View full text Add to dashboard Cite

Teneurin C-terminal associated peptides (TCAPs) are an evolutionarily ancient family of 40- to 41-residue bioactive peptides located on the extracellular end of each of the four teneurin transmembrane proteins. TCAP-1 may exist as a tethered peptide at the teneurin-1 carboxy end or as an independent peptide that is either released via post-transcriptional cleavage from its teneurin-1 pro-protein or independently expressed as its own mRNA. In neurons, soluble TCAP-1 acts as a paracrine factor to regulate cellular activity and neuroplastic interactions. In vitro studies indicate that, by itself, synthetic TCAP-1 promotes neuron growth and protects cells from chemical insult. In vivo , TCAP-1 increases hippocampal neuron spine density, reduces stress-induced behavior and ablates cocaine-seeking behaviors. Together, these studies suggest that the physiological effects of TCAP-1 are a result of an inhibition of corticotropin-releasing factor (CRF) activity leading to increased energy production. This hypothesis is supported by in vivo functional positron emissions tomography studies, which demonstrate that TCAP-1 significantly increases glucose uptake in rat brain. Complimentary in vitro studies show that enhanced glucose uptake is the result of TCAP-1-induced insertion of the glucose transporter into the neuronal plasma membrane, leading to increased glucose uptake and ATP production. Interestingly, TCAP-1-mediated glucose uptake occurs through a novel insulin-independent pathway. This review will focus on examining the role of TCAP on neuronal energy metabolism in the central nervous system.

show abstract

“…Considerable evidence establishes a commonality among the secretin peptide and secretin receptor superfamilies (including CRF and calcitonin) in the regulation of energy metabolism for homeostasis (81–83). Much like the Secretin family of peptides, TCAP has been implicated in the regulation of both cellular and organismal energy metabolism (82, 84, 85). Recently, TCAP-1 has been demonstrated to induce glucose uptake in murine neuronal cells in vitro using 3 H-deoxyglucose (DG) (86).…”

Section: Discovery and Characterization Of The Teneurin C-terminal Asmentioning

confidence: 99%

Synthetic Peptides as Therapeutic Agents: Lessons Learned From Evolutionary Ancient Peptides and Their Transit Across Blood-Brain Barriers

et al. 2019

Self Cite

View full text Add to dashboard Cite

Peptides play a major role in the transmission of information to and from the central nervous system. However, because of their structural complexity, the development of pharmacological peptide-based therapeutics has been challenged by the lack of understanding of endogenous peptide evolution. The teneurin C-terminal associated peptides (TCAP) possess many of the required attributes of a practical peptide therapeutic. TCAPs, associated with the teneurin transmembrane proteins that bind to the latrophilins, members of the Adhesion family of G-protein-coupled receptors (GPCR). Together, this ligand-receptor unit plays an integral role in synaptogenesis, neurological development, and maintenance, and is present in most metazoans. TCAP has structural similarity to corticotropin-releasing factor (CRF), and related peptides, such as calcitonin and the secretin-based peptides and inhibits the (CRF)-associated stress response. Latrophilins are structurally related to the secretin family of GPCRs. TCAP is a soluble peptide that crosses the blood-brain barrier and regulates glucose transport into the brain. We posit that TCAP represents a phylogenetically older peptide system that evolved before the origin of the CRF-calcitonin-secretin clade of peptides and plays a fundamental role in the regulation of cell-to-cell energy homeostasis. Moreover, it may act as a phylogenetically older peptide system that evolved as a natural antagonist to the CRF-mediated stress response. Thus, TCAP's actions on the CNS may provide new insights into the development of peptide therapeutics for the treatment of CNS disorders.

show abstract

Expression and actions of corticotropin-releasing factor/diuretic hormone-like peptide (CDLP) and teneurin C-terminal associated peptide (TCAP) in the vase tunicate, Ciona intestinalis : Antagonism of the feeding response

Cited by 14 publications

References 34 publications

Teneurins and Teneurin C-Terminal Associated Peptide (TCAP) in Metabolism: What’s Known in Fish?

Teneurins and Teneurin C-Terminal Associated Peptide (TCAP) in Metabolism: What’s Known in Fish?

Activity of the Carboxy-Terminal Peptide Region of the Teneurins and Its Role in Neuronal Function and Behavior in Mammals

Synthetic Peptides as Therapeutic Agents: Lessons Learned From Evolutionary Ancient Peptides and Their Transit Across Blood-Brain Barriers

Contact Info

Product

Resources

About