“…pp1a and pp1ab are considered to be cleaved into at least 16 nonstructural proteins (nsp1␣,nsp1,nsp2TF,nsp2N,nsp7a, upon infection by viral proteases nsp1␣, nsp1, nsp2, and nsp4. ORF2a, ORF2b, ORF3-7, and ORF5a encode eight structural proteins: a small, non-glycosylated E protein, five glycosylated membrane proteins (GP2-GP5 and GP5a), a non-glycosylated membrane protein (M), and the nucleocapsid protein (N) (Dokland, 2010;Fang and Snijder, 2010;Fang et al, 2012b;Li et al, 2014;Wei et al, 2013). These PRRSV proteins are involved in virus entry, replication and http://dx.doi.org/10.1016/j.virusres.2014.12.014 0168-1702/© 2014 Elsevier B.V. All rights reserved.…”