2013
DOI: 10.1007/s12088-013-0368-1
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Expression and Antibody Preparation of GP5a Gene of Porcine Reproductive and Respiratory Syndrome Virus

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Cited by 8 publications
(5 citation statements)
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“…pp1a and pp1ab are considered to be cleaved into at least 16 nonstructural proteins (nsp1␣,nsp1␤,nsp2TF,nsp2N,nsp7a, upon infection by viral proteases nsp1␣, nsp1␤, nsp2, and nsp4. ORF2a, ORF2b, ORF3-7, and ORF5a encode eight structural proteins: a small, non-glycosylated E protein, five glycosylated membrane proteins (GP2-GP5 and GP5a), a non-glycosylated membrane protein (M), and the nucleocapsid protein (N) (Dokland, 2010;Fang and Snijder, 2010;Fang et al, 2012b;Li et al, 2014;Wei et al, 2013). These PRRSV proteins are involved in virus entry, replication and http://dx.doi.org/10.1016/j.virusres.2014.12.014 0168-1702/© 2014 Elsevier B.V. All rights reserved.…”
Section: Introductionmentioning
confidence: 99%
“…pp1a and pp1ab are considered to be cleaved into at least 16 nonstructural proteins (nsp1␣,nsp1␤,nsp2TF,nsp2N,nsp7a, upon infection by viral proteases nsp1␣, nsp1␤, nsp2, and nsp4. ORF2a, ORF2b, ORF3-7, and ORF5a encode eight structural proteins: a small, non-glycosylated E protein, five glycosylated membrane proteins (GP2-GP5 and GP5a), a non-glycosylated membrane protein (M), and the nucleocapsid protein (N) (Dokland, 2010;Fang and Snijder, 2010;Fang et al, 2012b;Li et al, 2014;Wei et al, 2013). These PRRSV proteins are involved in virus entry, replication and http://dx.doi.org/10.1016/j.virusres.2014.12.014 0168-1702/© 2014 Elsevier B.V. All rights reserved.…”
Section: Introductionmentioning
confidence: 99%
“…PRRSV genome is approximately 15.4 kb in length and has at least 10 open reading frames (ORFs) [ 9 ]. Among them, ORF2a, ORF2b, ORF3-7, and ORF5a encode eight structural proteins: a small, non-glycosylated E protein, five glycosylated membrane proteins (GP2-GP5 and GP5a), a non-glycosylated membrane protein (M), and the nucleocapsid protein (N) [ 10 13 ].…”
Section: Introductionmentioning
confidence: 99%
“…The nonstructural proteins are encoded as polyprotein precursors from two open reading frames, ORF1a and ORF1ab. The precursors are thought to be cleaved into 15 nonstructural proteins (nsp1␣, nsp1␤, nsp2 to -6, nsp2TF, nsp7a, nsp7b, and nsp8 to -12) by four virus-encoded proteases upon infection (6)(7)(8). In addition to their protease activities in viral polyprotein processing, the viral proteases may act as "multitaskers" by interacting with key factors in innate immune response.…”
mentioning
confidence: 99%