Expression and distribution of cell adhesion-related proteins in bovine parthenogenetic embryos: The effects of oocyte vitrification

Zeng, Yan; Fu, Xiangwei; Zhou, Guangbin; Yue, Mingxing; Zhou, Yanhua; Zhu, Shi-En

doi:10.1016/j.theriogenology.2013.03.006

Cited by 7 publications

(1 citation statement)

References 49 publications

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“…Inactivation of this cell signaling pathway, as a consequence of E-cadherin mediated cell-cell contact inhibition, interferes with lineage segregation and, in turn, proper blastocyst development during mouse preimplantation embryogenesis [28,39,40]. E-cadherin is expressed during all the post compaction stages of bovine embryogenesis [41]. E-cadherin along with other catenins have been shown to play an essential role in establishing cell-cell contact in early bovine embryogenesis.…”

Section: How Do Cell-cell Contact and Cell Polarity Affect The Hippo mentioning

confidence: 99%

A Comparative Analysis of Hippo Signaling Pathway Components during Murine and Bovine Early Mammalian Embryogenesis

Sharma

Antenos

Madan

2021

Genes

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The time required for successful blastocyst formation varies among multiple species. The formation of a blastocyst is governed by numerous molecular cell signaling pathways, such as the Hippo signaling pathway. The Hippo signaling pathway is initiated by increased cell–cell contact and via apical polarity proteins (AMOT, PARD6, and NF2) during the period of preimplantation embryogenesis. Cell–cell contact and cell polarity activate (phosphorylates) the core cascade components of the pathway (mammalian sterile twenty like 1 and 2 (MST1/2) and large tumor suppressor 1 and 2 (LATS1/2)), which in turn phosphorylate the downstream effectors of the pathway (YAP1/TAZ). The Hippo pathway remains inactive with YAP1 (Yes Associated protein 1) present inside the nucleus in the trophectoderm (TE) cells (polar blastomeres) of the mouse blastocyst. In the inner cell mass (ICM) cells (apolar blastomeres), the pathway is activated with p-YAP1 present in the cytoplasm. On the contrary, during bovine embryogenesis, p-YAP1 is exclusively present in the nucleus in both TE and ICM cells. Contrary to mouse embryos, transcription co activator with PDZ-binding motif (TAZ) (also known as WWTR1) is also predominantly present in the cytoplasm in all the blastomeres during bovine embryogenesis. This review outlines the major differences in the localization and function of Hippo signaling pathway components of murine and bovine preimplantation embryos, suggesting significant differences in the regulation of this pathway in between the two species. The variance observed in the Hippo signaling pathway between murine and bovine embryos confirms that both of these early embryonic models are quite distinct. Moreover, based on the similarity of the Hippo signaling pathway between bovine and human early embryo development, bovine embryos could be an alternate model for understanding the regulation of the Hippo signaling pathway in human embryos.

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Section: How Do Cell-cell Contact and Cell Polarity Affect The Hippo mentioning

confidence: 99%

A Comparative Analysis of Hippo Signaling Pathway Components during Murine and Bovine Early Mammalian Embryogenesis

Sharma

Antenos

Madan

2021

Genes

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Developmental competence and gene expression of immature oocytes following liquid helium vitrification in bovine

Chen

et al. 2014

Cryobiology

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Microarray analysis of gene expression in parthenotes and in vitro–derived goat embryos

Singh¹,

Kumar²,

Mahapatra³

et al. 2014

Theriogenology

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Expression and distribution of cell adhesion-related proteins in bovine parthenogenetic embryos: The effects of oocyte vitrification

Cited by 7 publications

References 49 publications

A Comparative Analysis of Hippo Signaling Pathway Components during Murine and Bovine Early Mammalian Embryogenesis

A Comparative Analysis of Hippo Signaling Pathway Components during Murine and Bovine Early Mammalian Embryogenesis

Developmental competence and gene expression of immature oocytes following liquid helium vitrification in bovine

Microarray analysis of gene expression in parthenotes and in vitro–derived goat embryos

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