Expression and distribution of tuberoinfundibular peptide of 39 residues in the rat central nervous system

Dobolyi, Árpád; Palkovits, Miklós; Usdin, Ted B.

doi:10.1002/cne.10515

Cited by 59 publications

(133 citation statements)

References 65 publications

Supporting

Mentioning

128

Contrasting

Unclassified

Order By: Relevance

“…A ligand of PTH2R is a tuberoinfundibular peptide (TIP) isolated from bovine hypothalamus [42,43]. As both TIP and PTH2R are strongly expressed in the hypothalamus, it was considered that TIP acts on the nervous system in mammals [43,44]. In tilapia, however, TIP mRNA was expressed in excretory organs, such as the gill and kidney [45].…”

Section: Discussionmentioning

confidence: 99%

Parathyroid hormone 1 (1–34) acts on the scales and involves calcium metabolism in goldfish

Suzuki

Danks

Maruyama

et al. 2011

Bone

View full text Add to dashboard Cite

The effect of fugu parathyroid hormone 1 (fugu PTH1) on osteoblasts and osteoclasts in teleosts was examined with an assay system using teleost scale and the following markers: alkaline phosphatase (ALP) for osteoblasts and tartrate-resistant acid phosphatase (TRAP) for osteoclasts. Synthetic fugu PTH1 (1-34) (100 pg/ml to 10 ng/ml) significantly increased ALP activity at 6 h of incubation. High-dose (10 ng/ml) fugu PTH1 significantly increased ALP activity even after 18 h of incubation. In the case of TRAP activity, fugu PTH1 did not change at 6 h of incubation, but fugu PTH1 (100 pg/ml to 10 ng/ml) significantly increased TRAP activity at 18 h. Similar results were obtained for human PTH (1-34), but there was an even greater response with fugu PTH1 than with human PTH. In vitro, we demonstrated that both the receptor activator of the NF-B ligand in osteoblasts and the receptor activator NF-B mRNA expression in osteoclasts increased significantly by fugu PTH1 treatment. In an in vivo experiment, fugu PTH1 induced hypercalcemia resulted from the increase of both osteoblastic and osteoclastic activities in the scale as well as the decrease of scale calcium contents after fugu PTH1 injection. In addition, an in vitro experiment with intramuscular autotransplanted scale indicated that the ratio of multinucleated osteoclasts/mononucleated osteoclasts in PTH-treated scales was significantly higher than that in the control scales. Thus, we concluded that PTH acts on osteoblasts and osteoclasts in the scales and regulates calcium metabolism in goldfish.3

show abstract

Section: Discussionmentioning

confidence: 99%

Parathyroid hormone 1 (1–34) acts on the scales and involves calcium metabolism in goldfish

Suzuki

Danks

Maruyama

et al. 2011

Bone

View full text Add to dashboard Cite

show abstract

“…The expression of TIP39 in the central nervous system is restricted to two major sites, the subparafascicular area in the caudal thalamus and the medial paralemniscal nucleus in the lateral pons (Dobolyi et al, 2003b;Dobolyi et al, 2002). The distributions of TIP39 fibers (Dobolyi et al, 2003b) and the PTH2 receptor in the central nervous system have recently been described in young male rats.…”

Section: Introductionmentioning

confidence: 99%

“…The distributions of TIP39 fibers (Dobolyi et al, 2003b) and the PTH2 receptor in the central nervous system have recently been described in young male rats. PTH2 receptors and TIP39 fibers have similar distributions in many brain regions, suggesting that they form a neuromodulator system (Dobolyi et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…PTH2 receptors and TIP39 fibers have similar distributions in many brain regions, suggesting that they form a neuromodulator system (Dobolyi et al, 2006). TIP39 fibers and PTH2 receptors are abundant in the medial prefrontal cortex, the lateral septum, the amygdala, several different hypothalamic nuclei, the paraventricular thalamic nucleus, and the parabrachial nuclei (Dobolyi et al, 2006;Dobolyi et al, 2003b;Wang et al, 2000) suggesting limbic-endocrine functions for TIP39 (Dobolyi et al, 2003a;Usdin et al, 2003). Initial functional studies suggest that TIP39 is involved in the transmission of nociceptive information towards higher nociceptive centers (Dobolyi et al, 2002;.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Postnatal development and gender‐dependent expression of TIP39 in the rat brain

Dobolyi

Wang

Irwin

et al. 2006

J of Comparative Neurology

View full text Add to dashboard Cite

Tuberoinfundibular peptide of 39 residues (TIP39) is a selective agonist of the parathyroid hormone 2 (PTH2) receptor. The topographical distributions of TIP39 and the PTH2 receptor in the brain, described in young male rats, suggested that TIP39 has limbic and endocrine functions. In the present study, we investigated the expression of TIP39 and the PTH2 receptor in male and female rat brain during postnatal development by means of in situ hybridization histochemistry, quantitative RT-PCR and immunocytochemistry. TIP39's distribution and expression levels are similar in young female and male brains. TIP39 mRNA levels peak at postnatal day 14 and subsequently decline both in the subparafascicular area and the medial paralemniscal nucleus, the two major sites where TIP39 is synthesized. A greater developmental decrease in TIP39 expression in males leads to greater levels in older females than older males. The decrease is partially reversed by pre-pubertal but not post-pubertal gonadectomy. TIP39 peptide levels in cell bodies change in parallel with mRNA levels, while TIP39 appears and disappears somewhat later in nerve fibers. In addition, TIP39 peptide levels are also sexually dimorphic in older rats. In contrast, PTH2 receptor expression in the brain does not decrease during puberty and is not sexually dimorphic even in old animals. The appearance of TIP39 during early, and decline during late, postnatal development together with the gender dependent levels in mature animals suggest that TIP39 may play a role in sexual maturation or gender specific functions. Indexing termstuberoinfundibular peptide of 39 residues; parathyroid hormone 2 receptor; TIP39 and PTH2 receptor in situ hybridization and immunocytochemistry and quantitative

show abstract

“…Interestingly, neuroanatomical studies implicated that high-density TIP39 fibers project widely in many limbic areas, including the PVN and several hypothalamic nuclei. Earlier studies also implicated that TIP39 peptide potentially modulates the natural process of the HPA axis during stressful condition [24].…”

Section: Discussionmentioning

confidence: 93%

Neurochemical Assessment and Behavioral Role of Tuberoinfundibular Peptide-39 in Acute Restraint Stress-Induced Depression in Rats.

Sankar

Ramanathan²,

Venkatesh³

2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: Tuberoinfundibular peptide of 39 (TIP39) is a potent agonist to the parathyroid hormone 2 receptor (PTH2R) abundantly expressed in brain. The current study focused to evaluate the role of TIP39 in acute restraint stress (ARS)-induced depression model. Methods:Rats were exposed to ARS for 2 h to establish the depression and then subjected to open field and forced swim test (OFT and FST). TIP39 (1 and 10 nmol/rat) and HYWH (1 nmol/rat) are a PTH2R antagonist which was infused through intracerebroventricular route. Diazepam (2 mg/kg, i.p) was utilized as reference standard. Results:The results depict ARS significantly diminished the TIP39 expression in cerebral regions and causes depression-like behavior. TIP39 significantly decreased the immobility period in FST. In the OFT, TIP39 significantly increased the ambulatory activity and did not alter the rearing and grooming activity in comparison to ARS group. After TIP39 treatment, plasma noradrenaline levels were significantly increased, whereas the serotonin levels were unaltered. The corticosterone levels also decreased significantly. In rat brain tissues, TIP39 significantly reversed the abnormalities in glutamate and gamma-aminobutyric acid (GABA) level by ARS induction. In contrast, HYWH-treated rats did not show any significant variations in the neurochemical and behavioral parameters in comparison to ARS rats. Conclusion:Our reports submitted that the primary evidence depicting the stimulation of TIP39 expression could modulate the monoaminergic, GABAergic, and glutaminergic release with the support of hypothalamic-pituitary-adrenal axis that can be produced an antidepressant-like effect evident with the interactive study.

show abstract

Expression and distribution of tuberoinfundibular peptide of 39 residues in the rat central nervous system

Cited by 59 publications

References 65 publications

Parathyroid hormone 1 (1–34) acts on the scales and involves calcium metabolism in goldfish

Parathyroid hormone 1 (1–34) acts on the scales and involves calcium metabolism in goldfish

Postnatal development and gender‐dependent expression of TIP39 in the rat brain

Neurochemical Assessment and Behavioral Role of Tuberoinfundibular Peptide-39 in Acute Restraint Stress-Induced Depression in Rats.

Contact Info

Product

Resources

About