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Diabetic wounds or ulcers are major complication of diabetes mellitus. Diabetes is a metabolic disorder that impedes the normal steps of wound healing process Major increase in morbidity in diabetic patients is due to macro and micro vascular complications including failure of wound healing process. Diabetes is the cause for more than 3/4 th lower limb amputation Increased glucose in the tissue precipitates infection. The aim of this study is to establish whether topical application of human epidermal growth factor enhance wound healing better than conventional povidone-iodine dressing in diabetic wounds. For one group of patients, topical application of recombinant human epidermal growth factor gel over the wound and wound dressing was done twice daily For other group of patients, topical application of povidone-iodine over the wound and wound dressing done twice daily. The Human Epidermal Growth Factor Application group patients equally belonged to the male gender class interval (n=15, 50%). In the Conventional Povidone Iodine Dressing group patients, majority belonged to the male gender class interval (n=15, 50%). The association between the intervention groups and gender distribution is considered to be not statistically significant since p > 0.05 as per fishers exact test. The results of the study conclude that the topical application of human epidermal growth factor enhances wound healing significantly and is better than conventional povidine iodine dressing.

Objective: Tuberoinfundibular peptide of 39 (TIP39) is a potent agonist to the parathyroid hormone 2 receptor (PTH2R) abundantly expressed in brain. The current study focused to evaluate the role of TIP39 in acute restraint stress (ARS)-induced depression model. Methods:Rats were exposed to ARS for 2 h to establish the depression and then subjected to open field and forced swim test (OFT and FST). TIP39 (1 and 10 nmol/rat) and HYWH (1 nmol/rat) are a PTH2R antagonist which was infused through intracerebroventricular route. Diazepam (2 mg/kg, i.p) was utilized as reference standard. Results:The results depict ARS significantly diminished the TIP39 expression in cerebral regions and causes depression-like behavior. TIP39 significantly decreased the immobility period in FST. In the OFT, TIP39 significantly increased the ambulatory activity and did not alter the rearing and grooming activity in comparison to ARS group. After TIP39 treatment, plasma noradrenaline levels were significantly increased, whereas the serotonin levels were unaltered. The corticosterone levels also decreased significantly. In rat brain tissues, TIP39 significantly reversed the abnormalities in glutamate and gamma-aminobutyric acid (GABA) level by ARS induction. In contrast, HYWH-treated rats did not show any significant variations in the neurochemical and behavioral parameters in comparison to ARS rats. Conclusion:Our reports submitted that the primary evidence depicting the stimulation of TIP39 expression could modulate the monoaminergic, GABAergic, and glutaminergic release with the support of hypothalamic-pituitary-adrenal axis that can be produced an antidepressant-like effect evident with the interactive study.

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