A Comparative Study on Wound Healing with Topical Application of Human Epidermal Growth Factor verses Application of Povidone-Iodine in Diabetic Wounds

Abstract

Diabetic wounds or ulcers are major complication of diabetes mellitus. Diabetes is a metabolic disorder that impedes the normal steps of wound healing process Major increase in morbidity in diabetic patients is due to macro and micro vascular complications including failure of wound healing process. Diabetes is the cause for more than 3/4 th lower limb amputation Increased glucose in the tissue precipitates infection. The aim of this study is to establish whether topical application of human epidermal growth factor enhance wound healing better than conventional povidone-iodine dressing in diabetic wounds. For one group of patients, topical application of recombinant human epidermal growth factor gel over the wound and wound dressing was done twice daily For other group of patients, topical application of povidone-iodine over the wound and wound dressing done twice daily. The Human Epidermal Growth Factor Application group patients equally belonged to the male gender class interval (n=15, 50%). In the Conventional Povidone Iodine Dressing group patients, majority belonged to the male gender class interval (n=15, 50%). The association between the intervention groups and gender distribution is considered to be not statistically significant since p > 0.05 as per fishers exact test. The results of the study conclude that the topical application of human epidermal growth factor enhances wound healing significantly and is better than conventional povidine iodine dressing.

Ultrasound-Mediated EGF-Coated-Microbubble Cavitation in Dressings for Wound-Healing Applications

“…Moreover, the topical application of human EGF gel over a wound and wound dressing enhanced wound healing significantly, and was more effective than a conventional povidine iodine dressing. EGF was also found to reduce the number of nonhealing ulcers 12 . A novel polymeric bilayer wound dressing containing EGF-loaded microspheres was synthesized in 2001, and two different doses of EGF were added to prepared gelatin sponges (1 and 15 μg/cm 2 ) to activate cell proliferation, with the EGF added either in free form or within microspheres to achieve prolonged release of EGF so as to increase the efficiency 13 .…”