Expression and function of colony-stimulating factors and their receptors in human prostate carcinoma cell lines

Savarese, Diane; Valinski, Helen; Quesenberry, Peter J.; Savarese, Todd M.

doi:10.1002/(sici)1097-0045(19980201)34:2<80::aid-pros2>3.0.co;2-n

Cited by 58 publications

(29 citation statements)

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“…9, which is published as supporting information on the PNAS web site). (43). Gene expression databases using microarray data (Unigene, www.ncbi.nlm.nih.gov͞UniGene͞ Hs.Home.html), EST analyses (GeneCards, Weizmann Institute of Science, http:͞͞bioinformatics.weizmann.ac.il͞cards͞), or serial analysis of gene expression (National Center for Biotechnology Information, www.ncbi.nlm.nih.gov͞SAGE͞) show moderate to high levels of expression of CSF-1R sequences in human prostate cancer-derived samples.…”

Section: Csf-1r Expression In Mouse Prostatementioning

confidence: 99%

Expression of colony-stimulating factor 1 receptor during prostate development and prostate cancer progression

Ide

Seligson²,

Memarzadeh³

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

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Section: Csf-1r Expression In Mouse Prostatementioning

confidence: 99%

Expression of colony-stimulating factor 1 receptor during prostate development and prostate cancer progression

Ide

Seligson²,

Memarzadeh³

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

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“…Granulocyte-macrophage-colony stimulating factor (GM-CSF), along with IL-6, epidermal growth factor, IGF-1 and fibroblast growth factor are among the growth factors known to be important regulators of prostate carcinoma cells (Davies & Eaton 1989, Rivas et al 1998, Savarese et al 1998, Chung et al 1999, Ruan et al 1999, DiGiovanni et al 2000, OlapadeOlaopa et al 2000, Ozen et al 2001. The receptor for GM-CSF (GMR) is expressed in prostate carcinoma cell lines and in primary prostate tumor ( Rivas et al 1998, Savarese et al 1998. Some prostate carcinomas produce GM-CSF, resulting in autocrine mediated proliferation and growth factor independence (Lang et al 1994, Rokhlin et al 1996.…”

Section: Introductionmentioning

confidence: 99%

Magmas expression in neoplastic human prostate

et al. 2005

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Magmas, is a 13-kDa mitochondrial protein which is ubiquitously expressed in eukaryotic cells. It was identified as a granulocyte-macrophage-colony stimulating factor (GM-CSF) inducible gene in hematopoietic cells and has a key role in the transport of mitochondrial proteins in yeast. Because GM-CSF receptor levels are elevated in prostate cancer, Magmas expression was examined in normal and neoplastic tissue. Magmas protein levels were barely detectable in non-neoplastic prostate glands. Increased amounts were observed in some samples of intraepithelial neoplasia. Approximately one half of the adenocarcinoma samples examined had weak Magmas expression, while the remainder had intermediate to high levels. The increased Magmas observed in malignant tissue was a result of higher protein expression and not from changes in mitochondrial content. Interestingly, in some patients, the normal prostate tissue had more Magmas message than the malignant portion. The results indicated that Magmas expression in prostate cancer is heterogeneous and independent of clinical stage and Gleason score. Further studies are needed to determine if Magmas expression has prognostic significance in prostate cancer.

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“…IL9R encodes the receptor for IL-9 [29] while CSFR2A and IL3RA encode the a subunits of receptors for the granulocyte-macrophage colony-stimulating factor (GM-CSF) and the IL-3, respectively [35][36][37][38][39][40][41][42], Each a subunit exhibits specific affinity to the respective growth factor but requires heterodimerization with the ß subunit to form a fully functional receptor [35][36][37][38]. Recent studies have demonstrated that GM-CSF and its receptors are expressed in prostatic cell lines LNCaP, PC3, and DU-145 [39][40][41]. Further recombinant human GM-CSF stimulates proliferation of the LNCaP cells in vitro [40], suggesting that prostatic cells are responsive to this hematopoietic factor.…”

Section: Discussionmentioning

confidence: 99%

“…The up-regulation of the three cytokine receptor genes, IL9R, CSFR2A, and IL3RA, suggests that cytokines and their receptors may play a role(s) in androgenstimulated proliferation in this prostatic cell line. IL9R encodes the receptor for IL-9 [29] while CSFR2A and IL3RA encode the a subunits of receptors for the granulocyte-macrophage colony-stimulating factor (GM-CSF) and the IL-3, respectively [35][36][37][38][39][40][41][42], Each a subunit exhibits specific affinity to the respective growth factor but requires heterodimerization with the ß subunit to form a fully functional receptor [35][36][37][38]. Recent studies have demonstrated that GM-CSF and its receptors are expressed in prostatic cell lines LNCaP, PC3,.…”

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confidence: 99%

The Roles of the Y Chromosome Genes in Prostate Cancer

Lau¹

2003

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302, and to the Office of Management and Budget, Paperwork Reduction Project (0704-0188), Washington, DC 20503 AGENCY USE ONLY (Leave blank)2. REPORT DATE February 2 001 REPORT TYPE AND DATES COVEREDAnnual (15 Jan 00 -14 Jan 01) TITLE AND SUBTITLE The Role of the Y Chromosome Genes in Prostate Cancer AUTHOR(S)Yun-Fai Chris Lau, Ph.D. FUNDING NUMBERS DAMD17-00-1-0039 PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES)Northern California Institute for Research and Education San Francisco, California 94121 E-Mail: clau@itsa.ucsf.edu At present, information regarding the contribution of the men-only chromosome, the Y chromosome, to prostate cancer is lacking. PERFORMING ORGANIZATION REPORT NUMBER SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES)UThe goals of this project are designed to address this question and to identify candidate genes on the Y chromosome involved in prostate cancer.The objectives are: 1) to study the expression of Y chromosome genes in prostate cancer and 2) to evaluate their effects in over-expression in the prostate of transgenic mice.In year 1, we completed the expression survey of all 31 functional genes on this chromosome.Results from this study identified the TSPY gene to potentially play a significant role in prostate cancer development and/or progression.For the next two years of the project, we plan to focus on an expression-function evaluation of TSPY and other Y chromosome genes using transgenic mouse approach, proposed under Objective 2. These studies will provide important information regarding the role of this male-specific chromosome on prostatic oncogenesis and in development of new diagnostic procedures, and/or treatment for this disease.In addition, the generation of transgenic mouse models of prostate cancer will be invaluable in understanding the disease mechanisms, therapeutic strategies and prevention of prostate cancer. References 10 SUBJECT TERMSAppendices 11 INTRODUCTIONThe role of the Y chromosome in prostate cancer has been debated on numerous occasions (see reference 1 for review). Both a gain and a loss of this chromosome had been reported in the literature, suggesting the possible existence of an oncogene and tumor suppressor gene respectively. In the past, studies on the function of the Y chromosome in oncogenesis of male-specific organs, such as the prostate gland and testis, are limited due to the lack of information on the genetic content of this chromosome. Recent advances in positi...

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Expression and function of colony-stimulating factors and their receptors in human prostate carcinoma cell lines

Cited by 58 publications

References 44 publications

Expression of colony-stimulating factor 1 receptor during prostate development and prostate cancer progression

Expression of colony-stimulating factor 1 receptor during prostate development and prostate cancer progression

Magmas expression in neoplastic human prostate

The Roles of the Y Chromosome Genes in Prostate Cancer

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