Expression and Function of Ganglioside 9-O-Acetyl GD3 in Postmitotic Granule Cell Development

Santiago, Marcelo F.; Berrêdo-Pinho, Márcia; Costa, Marcos Romualdo; Gandra, Mario; Cavalcante, Leny A.; Mendez-Otero, Rosália

doi:10.1006/mcne.2000.0943

Cited by 41 publications

(53 citation statements)

References 57 publications

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“…In these regions, cells are found with migratory profiles. The observation that labeling with Jones mAb is restricted to regions of cell migration is consistent with previous reports that have suggested that the ganglioside 9-O-acetyl GD3 is a marker for neuronal migration in the developing Schlosshauer et al, 1988;Mendez-Otero and Ramon-Cueto, 1994;Miyakoshi et al, 2001;Santiago et al, 2001) (for review, see Mendez-Otero and Santiago, 2001) and adult (Mendez-Otero and Cavalcante, 1996) nervous system. We also show that the antibody against 9-Oacetyl GD3 arrests granule cells in the external granular cell layer and diminishes the number of BrdU-positive granule cells in the internal granular cell layer by 57%.…”

Section: Discussionsupporting

confidence: 90%

Immunoblockage of 9-O-Acetyl GD3 Ganglioside Arrests theIn VivoMigration of Cerebellar Granule Neurons

Santiago¹,

Costa²,

Mendez-Otero³

2004

J. Neurosci.

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Section: Discussionsupporting

confidence: 90%

Immunoblockage of 9-O-Acetyl GD3 Ganglioside Arrests theIn VivoMigration of Cerebellar Granule Neurons

Santiago¹,

Costa²,

Mendez-Otero³

2004

J. Neurosci.

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“…We have also used cerebellar explants and slices from postnatal rat cerebellum in antibody perturbation assays to investigate the functional role of these ganglioside in granule cell migration. We found that although other receptor systems can support neuronal movement, blocking 9-O-acetyl GD3 reduces the rate of neuronal locomotion by approximately 66% (Santiago et al 2001).…”

Section: Gangliosides and Cell Migrationmentioning

confidence: 78%

Functional role of a glycolipid in directional movements of neurons

Mendez-Otero

Santiago

2001

An. Acad. Bras. Ciênc.

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Migration of neurons from their site of origin to their final destination is a critical and universal step in the formation of the complex structure of the nervous system. The migratory process is thought to be governed in part by genetically and epigenetically defined sequences of signals which are interpreted by migrating cells. The molecular mechanisms that underlie neuronal migration have been the subject of intense investigation. As in other developmental processes, many molecules must participate in neuronal migration. Some molecules, such as cell adhesion molecules and motor proteins, may contribute to discrete steps in the migration act; others, like extracellular signaling molecules, may regulate the activation and/or termination of the migration program. In this article we review findings from our group that demonstrate the functional role(s) of a specific glycolipid in neuronal migration and neurite outgrowth in the developing and adult nervous system.

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“…However, this result may be due to a direct effect on proliferation (22) It may not be surprising that ganglioside 9-O-acGD3 is involved in RMS cell migration since it is expressed in a spatiotemporally regulated manner in regions in which cell migration and process outgrowth occur in the developing CNS and peripheral nervous system (48). This glycolipid has been directly implicated in external granule cell radial migration in the cerebellum (48,49). Initially it was thought to mediate only gliophilic migration via a homophilic interaction of this ganglioside on the surface of migrating neuronal precursors and radial glial cells (48).…”

Section: Cell Contact-mediating Moleculesmentioning

confidence: 99%

Cell migration in the postnatal subventricular zone

Menezes

Marins

Alves

et al. 2002

Braz J Med Biol Res

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New neurons are constantly added to the olfactory bulb of rodents from birth to adulthood. This accretion is not only dependent on sustained neurogenesis, but also on the migration of neuroblasts and immature neurons from the cortical and striatal subventricular zone (SVZ) to the olfactory bulb. Migration along this long tangential pathway, known as the rostral migratory stream (RMS), is in many ways opposite to the classical radial migration of immature neurons: it is faster, spans a longer distance, does not require radial glial guidance, and is not limited to postmitotic neurons. In recent years many molecules have been found to be expressed specifically in this pathway and to directly affect this migration. Soluble factors with inhibitory, attractive and inductive roles in migration have been described, as well as molecules mediating cell-to-cell and cell-substrate interactions. However, it is still unclear how the various molecules and cells interact to account for the special migratory behavior in the RMS. Here we will propose some candidate mechanisms for roles in initiating and stopping SVZ/RMS migration.

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Expression and Function of Ganglioside 9-O-Acetyl GD3 in Postmitotic Granule Cell Development

Cited by 41 publications

References 57 publications

Immunoblockage of 9-O-Acetyl GD3 Ganglioside Arrests theIn VivoMigration of Cerebellar Granule Neurons

Immunoblockage of 9-O-Acetyl GD3 Ganglioside Arrests theIn VivoMigration of Cerebellar Granule Neurons

Functional role of a glycolipid in directional movements of neurons

Cell migration in the postnatal subventricular zone

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