Expression and Function of Kisspeptin during Mouse Decidualization

Zhang, Peng; Tang, Min; Zhong, Ting; Lin, Yan; Zong, Teng; Zhong, Chengxue; Zhang, Baoping; Ren, Min; Kuang, Haibin

doi:10.1371/journal.pone.0097647

Cited by 45 publications

(59 citation statements)

References 32 publications

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“…Additionally, because exogenous gonadotropins, E 2 and progesterone could not rescue the implantation failure, we concluded that the defect was uterine based (Calder et al 2014) and considered that it was the lack of a functional uterine-based kisspeptin signaling system in the null female that disrupted embryo implantation. In support of this idea, we found that on the day of implantation (D4 of pregnancy), the WT mouse uterus expresses kisspeptin and Kiss1r, a finding also made by Zhang et al (2014) based on both RT-PCR and immunohistochemical analyses. More importantly, we also demonstrated that at this critical peri-implantation period, the WT uterus expresses a functional kisspeptin/ KISS1R signaling system localized to both the luminal and glandular epithelia (Fig.…”

Section: Kisspeptin Positively Regulates Embryo Implantationsupporting

confidence: 67%

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Uterine and placental KISS1 regulate pregnancy: what we know and the challenges that lie ahead

Babwah¹

2015

Reproduction

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Hypothalamic KISS1 and its derivatives (kisspeptins) are now well recognized as potent stimulators of GnRH secretion and thereby major regulators of the neuroendocrine-reproductive axis. Recent studies in the mouse strongly suggest that independent of the hypothalamus and pituitary, peripherally derived KISS1 also regulates fertility, and disruption of local KISS1 signaling in the ovary and uterus is sufficient to trigger infertility. With this increasing recognition that peripherally derived KISS1 regulates fertility, the first goal of this review is to critically discuss the data that have led to this conclusion, focusing on uterine-and placental-derived KISS1. Given that a significant amount of this data was generated in animals such as the mouse and rat, a second goal of this review is to identify and discuss the limitations of the animal data in the context of better understanding KISS1 as a regulator of human pregnancy. The growing evidence suggests that in both man and mouse, KISS1 plays an important role in regulating very early pregnancy events such as embryo implantation. However, as pregnancy advances, although it seems that KISS1 continues to play important roles in regulating human pregnancy, it might not do so in the mouse. This surprising functional dichotomy between human females and mice appears also to exist between women and a large number of animal species, including lower primates. These findings are of tremendous significance and will greatly shape how KISS1 will be developed as a therapeutic agent in augmenting the reproductive potential of both women and important livestock species.Reproduction (2015) 150 R121-R128

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Section: Kisspeptin Positively Regulates Embryo Implantationsupporting

confidence: 67%

“…However, Zhang et al (2014) found that the expression of Kiss1 and Kiss1r in the mouse uterus was not transiently restricted to the periimplantation period. Instead, they found that between D5 and D8 the expression of these molecules increased significantly in the pseudopregnant uterus during artificially induced decidualization.…”

Section: Kiss1mentioning

confidence: 93%

Uterine and placental KISS1 regulate pregnancy: what we know and the challenges that lie ahead

Babwah¹

2015

Reproduction

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“…Although the process of decidualisation is different in humans, occurring before implantation in contrast to the post-implantation process occurring in rodents (Zhang et al 2014), the findings suggested a possible mechanism underlying the relationship between kisspeptin and placental function. Evidence has also demonstrated that not only does Kiss1 and Kiss1r mRNA expression increase, but that in rodents during implantation, a functional kisspeptin signalling system exists.…”

Section: Implantation and Placental Functionmentioning

confidence: 88%

“…Zhang and coworkers reported uterine expression of Kiss1 and Kiss1r mRNA was significantly greater with decidualisation (P < 0.01) (Zhang et al 2014). Interestingly, this was also observed in pseudopregnancy, suggesting a process independent of the developing embryo.…”

Section: Implantation and Placental Functionmentioning

confidence: 90%

Kisspeptin across the human lifespan:evidence from animal studies and beyond

Clarke

Dhillo

2016

Journal of Endocrinology

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Since its first description in 1996, the KISS1 gene and its peptide products, kisspeptins, have increasingly become recognised as key regulators of reproductive health. With kisspeptins acting as ligands for the kisspeptin receptor KISS1R (previously known as GPR54 or KPR54), recent work has consistently shown that administration of kisspeptin across a variety of species stimulates gonadotrophin release through influencing gonadotrophin-releasing hormone secretion. Evidence from both animal and human studies supports the finding that kisspeptins are crucial for ensuring healthy development, with knockout animal models, as well as proband genetic testing in human patients affected by abnormal pubertal development, corroborating the notion that a functional kisspeptin receptor is required for appropriate gonadotrophin secretion. Given the large body of evidence that exists surrounding the influence of kisspeptin in a variety of settings, this review summarises our physiological understanding of the role of these important peptides and their receptors, before proceeding to describe the varying role they play across the reproductive lifespan.

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“…It was explained further that localised uterine kisspeptin signalling modulates embryo implantation by regulating localised leukocyte inhibitory factor (LIF) secretion, which has been shown to be critical for implantation in mice [162,163]. Similarly, studies in mice have shown increased expression of kiss1 and kiss1r at the time of endometrial decidualisation, and the process was attenuated by downregulating kiss1 expression [164].…”

Section: Prace Poglądowementioning

confidence: 99%

Rola sygnalizacji kisspeptyny w osi podwzgórze–przysadka–nadnercza — aktualna perspektywa

Javed

Qamar

Sathyapalan

2015

Endokrynologia Polska

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The discovery of kisspeptins in the recent past remoulded current understanding of the neuroendocrine axis relating to the regulation of human puberty and reproduction. Kisspeptins have been recognised to act upstream of GnRH and have been shown to play a vital role in the control of the hypothalamic-pituitary-gonadal axis via regulation of gonadotrophin secretion, onset of puberty, and control of fertility. KNDy (kisspeptin/neurokinin-B/dynorphin) neurons have been suggested to modulate GnRH pulsatile secretion, which is required to support reproductive function in both sexes. They have also been involved in mediating both positive and negative sex steroid feedback signals to GnRH neurons and serve as a vital connection between reproduction and metabolic status of the body. When kisspeptin is administered to healthy humans, and in patients with reproductive disorders, it strongly and directly stimulates GnRH and subsequent LH secretion and enhances LH pulse frequency. These observations suggest that kisspeptins are a potential novel therapeutic approach for treating disorders with either pathologically reduced or augmented gonadotrophins pulsatile secretion and is currently a focus of translational research. Kisspeptins have also been identified in several peripheral reproductive organs, indicating their role in modulation of ovarian function, embryo implantation, and placentation, but a great deal of work remains to be done to explore further in this regard, and the evidence is only available from studies done on animal models. In this review we will mainly focus on current available evidence related to the role of kisspeptins in controlling GnRH pulse frequency, specifically their role in puberty, fertility, and reproduction. We will also be appraising other factors that regulate the kiSS1/Kisspeptin/GPR-54 system. StreszczenieOdkrycie kisspeptyn, które miało miejsce całkiem niedawno, odmieniło obecne rozumienie osi neuroendokrynnej, związanej z regulacją okresu dojrzewania i rozrodu. Odkryto, że kisspeptyny działają przed GnRH i odgrywają istotną rolę w kontroli osi podwzgórze-przysadka-nadnercza poprzez regulację wydzielania gonadotropiny, rozpoczęcia okresu dojrzewania oraz kontroli płodności. Zasugerowano, że komórki KNDy (kisspeptyna/neurokinina-B/dynorfina) modulują pulsacyjne uwalnianie GnRH, wymagane, aby wspomagać funkcję rozrodczą u obu płci. Komórki te są również zaangażowane w przekazywanie zarówno pozytywnych, jak i negatywnych sygnałów hormonów płciowych do neuronów GnRH, a także stanowią kluczowe połączenie między reprodukcją i stanem metabolicznym ciała. Kiedy kisspeptyna jest podawana jednostkom zdrowym i pacjentom z zaburzeniami płodności, silnie i bezpośrednio stymuluje GnPH i dalsze uwalnianie LH oraz poprawia częstotliwość impulsów LH. Obserwacje te przedstawiają kisspeptyny jako nowe potencjalne terapeutyczne podejście w leczeniu zaburzeń patologicznie obniżonego lub zwiększonego pulsacyjnego uwalniania gonadotropin i obecnie stanowi główny punkt zainteresowania badań przekładaj...

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Expression and Function of Kisspeptin during Mouse Decidualization

Cited by 45 publications

References 32 publications

Uterine and placental KISS1 regulate pregnancy: what we know and the challenges that lie ahead

Uterine and placental KISS1 regulate pregnancy: what we know and the challenges that lie ahead

Kisspeptin across the human lifespan:evidence from animal studies and beyond

Rola sygnalizacji kisspeptyny w osi podwzgórze–przysadka–nadnercza — aktualna perspektywa

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