Expression and localization of CKLFSF2 in human spermatogenesis

Liu, Gang; Xin, Zhongcheng; Chen, Liang; Tian, Long; Yuan, Yiming; Song, Weidong; Jiang, Xuejun; Guo, Yinglu

doi:10.1111/j.1745-7262.2007.00249.x

Cited by 16 publications

(6 citation statements)

References 17 publications

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“…Cres mRNA is mainly transcribed in round spermatids, whereas the protein is synthesized in elongating spermatids [15]. CKLFSF2 mRNA is localized in the pachytene primary spermatocytes, not wholly consistent with the protein that is localized in meiotic and post-meiotic germ cells [16]. The c-mos mRNA increased dramatically from day 25 to 30, whereas the predominant increase of c-Mos protein occurred from day 35 to 49.…”

Section: Discussionmentioning

confidence: 97%

Spatial and temporal expression of c-mos in mouse testis during postnatal development

Cao¹,

Ding²,

Yuan³

et al. 2008

Asian J Andrology

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Section: Discussionmentioning

confidence: 97%

Spatial and temporal expression of c-mos in mouse testis during postnatal development

Cao¹,

Ding²,

Yuan³

et al. 2008

Asian J Andrology

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“…In addition to the previously known mutations, we found a novel mutation at CMTM2 (Table 2 ), and for the first time, we demonstrated its effect on cellular proliferation. CMTM2 is a member of a chemokine-like factor superfamily that regulates vesicular transport or membrane apposition events in the endoplasmic reticulum 33 . The DGC patients with lower CMTM2 expression had a shorter overall survival (Fig.…”

Section: Discussionmentioning

confidence: 99%

Identification of genomic aberrations associated with lymph node metastasis in diffuse-type gastric cancer

et al. 2018

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Diffuse-type gastric cancer (DGC) is a GC subtype with heterogeneous clinical outcomes. Lymph node metastasis of DGC heralds a dismal progression, which hampers the curative treatment of patients. However, the genomic heterogeneity of DGC remains unknown. To identify genomic variations associated with lymph node metastasis in DGC, we performed whole exome sequencing on 23 cases of DGC and paired non-tumor tissues and compared the mutation profiles according to the presence (N3, n = 13) or absence (N0, n = 10) of regional lymph node metastasis. Overall, we identified 185 recurrently mutated genes in DGC, which included a significant novel mutation at CMTM2, as well as previously known mutations at CDH1, RHOA, and TP53. Noticeably, CMTM2 expression could predict the prognostic outcomes of DGC but not intestinal-type GC (IGC), indicating pivotal roles of CMTM2 in DGC progression. In addition, we identified a recurrent loss of heterozygosity (LOH) of DNA copy numbers at the 3p12-pcen locus in DGC. A comparison of N0 and N3 tumors showed that N3 tumors exhibited more frequent DNA copy number aberrations, including copy-neutral LOH and mutations of CpTpT trinucleotides, than N0 tumors (P = 0.2 × 10−3). In conclusion, DGCs have distinct profiles of somatic mutations and DNA copy numbers according to the status of lymph node metastasis, and this might be helpful in delineating the pathobiology of DGC.

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“…Choi et al found a novel mutation at CMTM2 in addition to the previously known mutations and they suggested that it may play a crucial role in development of DGC [46]. CMTM2 is a chemokine-like factor that regulates vesicular transport or membrane apposition events belonging to the CMTM family (e.g., CMTM3, CMTM4, CMTM7, and CMTM8), which play a role in the tumor suppression [110,111,112,113]. …”

Section: Factors Associated With Molecular Pathogenicity Of Dgcmentioning

confidence: 99%

Diffuse Gastric Cancer: A Summary of Analogous Contributing Factors for Its Molecular Pathogenicity

Ansari

Gantuya

Tuan

et al. 2018

IJMS

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Gastric cancer is the third leading cause of cancer-related deaths and ranks as the fifth most common cancer worldwide. Incidence and mortality differ depending on the geographical region and gastric cancer ranks first in East Asian countries. Although genetic factors, gastric environment, and Helicobacter pylori infection have been associated with the pathogenicity and development of intestinal-type gastric cancer that follows the Correa’s cascade, the pathogenicity of diffuse-type gastric cancer remains mostly unknown and undefined. However, genetic abnormalities in the cell adherence factors, such as E-cadherin and cellular activities that cause impaired cell integrity and physiology, have been documented as contributing factors. In recent years, H. pylori infection has been also associated with the development of diffuse-type gastric cancer. Therefore, in this report, we discuss the host factors as well as the bacterial factors that have been reported as associated factors contributing to the development of diffuse-type gastric cancer.

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Expression and localization of CKLFSF2 in human spermatogenesis

Abstract: CKLFSF2 could play important roles in the process of meiosis and spermiogenesis, and might be involved in the vesicular transport or membrane apposition events in the endoplasmic reticulum.

Cited by 16 publications

References 17 publications

Spatial and temporal expression of c-mos in mouse testis during postnatal development

Spatial and temporal expression of c-mos in mouse testis during postnatal development

Identification of genomic aberrations associated with lymph node metastasis in diffuse-type gastric cancer

Diffuse Gastric Cancer: A Summary of Analogous Contributing Factors for Its Molecular Pathogenicity

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