Expression and significance of E-cadherin, N-cadherin, transforming growth factor-β1 and Twist in prostate cancer

Liu, Ge-Liang; Yang, Hanjie; Liu, Tian; Lin, Yun-Zhao

doi:10.1016/s1995-7645(13)60196-0

Cited by 43 publications

(36 citation statements)

References 21 publications

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“…It has been shown that the blockage of TGF-β causes upregulation of E-cadherin resulting in the reduction of migration and invasion of carcinoma cells 38 and then TGF-β1 expression negatively correlated with E-cadherin expression. 39 Our results are consistent with the literature in terms of elevated serum TGF-β1 levels and reduced sEcadherin levels. It was assumed that increased TGF-β1 levels may be associated with decreased E-Cadherin expression in endometrial and ovarian cancers.…”

Section: Turan Et Al Vitronectin Se-cadherin and Tgf-β1 Levels In Esupporting

confidence: 92%

Assessment of Vitronectin, Soluble Epithelial-Cadherin and TGF-β1 as a Serum Biomarker with Predictive Value for Endometrial and Ovarian Cancers

Turan

Torun

Atalay

et al. 2017

tjps

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ÖZAmaç: Vitronektin, çözünür epitelyal-cadherin (sE-cadherin) ve transforming büyüme faktörü-beta 1'i (TGF-β1) içeren ekstrasellüler matriks elemanları kanserin invazyonu ve metastazında anahtar rol oynamaktadır. Bu çalışmada endometriyal ve over kanserli hastalarda bu moleküllerin serum düzeylerinin klinik önemini belirlemek amaçlanmıştır. Gereç ve Yöntemler: Bu çalışmada, 28 endometriyum kanseri hastası, 40 over kanseri hastası ve 41 sağlıklı kontrol grubuna ait serum vitronektin (VN), sE-cadherin ve TGF-β1 düzeyleri ELISA yöntemiyle ticari kitler kullanılarak ölçülmüştür. Bulgular: Total hasta grubunda, sağlıklı kontrollere kıyasla VN, sE-cadherin ve TGF-β1 düzeylerinde anlamlı bir farklılık bulunmuştur (sırasıyla p<0,01; p<0,01 ve p<0,05). Serum VN ve sE-cadherin düzeyleri hem endometriyal hem de over kanseri hastalarında kontrol grubuna kıyasla önemli ölçüde düşük bulunmuştur (p<0,01). Buna karşın, TGF-β1 düzeyleri, kontrol grubuna kıyasla over kanserinde anlamlı derecede yükselmiştir (p<0,01), ancak sağlıklı kontroller ile endometriyal kanserli hastalar arasında anlamlı bir fark bulunamamıştır. Sonuç: Çalışmamız serum VN ve sE-cadherin düzeylerinin, endometriyal ve over kanserlerinde yeni tanı yöntemleri sağlamak için aday hedefler olabileceğini ortaya koymaktadır. Anahtar kelimeler: Vitronektin, sE-cadherin, TGF-β1, endometriyal kanser, over kanseri Objectives: Extracellular matrix components, including vitronectin (VN), soluble epithelial-cadherin (sE-cadherin) and transforming growth factorbeta 1 (TGF-β1), play a key role in the invasion and metastasis of cancer. The objective of the study was to determine the clinical significance of serum levels of these molecules in patients with endometrial and ovarian cancers. Materials and Methods: Serum levels of VN, sE-cadherin and TGF-β1 in patients with endometrial (n=28) and ovarian cancers (n=40) and healthy controls (n=41) were measured by ELISA using commercial kits. Results: A significant difference was found in VN, sE-cadherin and TGF-β1 levels between patients and healthy controls (p<0.01, p<0.01 and p<0.05, respectively). Serum VN and sE-cadherin levels were decreased significantly in both endometrial and ovarian cancer patients compared to controls (p<0.01, p<0.01, respectively). Conversely, TGF-β1 levels were increased significantly in patients with ovarian cancer as compared to controls (p<0.01). There was no significant difference between healthy controls and endometrial cancer patients. Conclusion: In conclusion, our study reveals that serum VN, sE-cadherin and TGF-β1 levels can be candidate targets for providing new diagnostic procedures in endometrial and ovarian cancers.

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Section: Turan Et Al Vitronectin Se-cadherin and Tgf-β1 Levels In Esupporting

confidence: 92%

Assessment of Vitronectin, Soluble Epithelial-Cadherin and TGF-β1 as a Serum Biomarker with Predictive Value for Endometrial and Ovarian Cancers

Turan

Torun

Atalay

et al. 2017

tjps

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“…Increased expression of both TGFβ and Twist are associated with the cadherin switch in EMT and play an important role in the development of PCa [23]. The role of Twist in the down-modulation of E-cadherin is well-established and Twist expression has been shown to predict the metastatic potential of primary PCa [46].…”

Section: Resultsmentioning

confidence: 99%

Epithelial mesenchymal-like transition occurs in a subset of cells in castration resistant prostate cancer bone metastases

Haider

Zhang

Coleman

et al. 2015

Clin Exp Metastasis

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TGFβ is a known driver of epithelial-mesenchymal transition (EMT) which is associated with tumor aggressiveness and metastasis. However, EMT has not been fully explored in clinical specimens of castration-resistant prostate cancer (CRPC) metastases. To assess EMT in CRPC, gene expression analysis was performed on 149 visceral and bone metastases from 62 CRPC patients and immunohistochemical analysis was performed on 185 CRPC bone and visceral metastases from 42 CRPC patients. In addition, to assess the potential of metastases to seed further metastases the mitochondrial genome was sequenced at different metastatic sites in one patient. TGFβ was increased in bone versus visceral metastases. While primarily cytoplasmic; nuclear and cytoplasmic Twist were significantly higher in bone than in visceral metastases. Slug and Zeb1 were unchanged, with the exception of nuclear Zeb1 being significantly higher in visceral metastases. Importantly, nuclear Twist, Slug, and Zeb1 were only present in a subset of epithelial cells that had an EMT-like phenotype. Underscoring the relevance of EMT-like cells, mitochondrial sequencing revealed that metastases could seed additional metastases in the same patient. In conclusion, while TGFβ expression and EMT-associated protein expression is present in a considerable number of CRPC visceral and bone metastases, nuclear Twist, Slug, and Zeb1 localization and an EMT-like phenotype (elongated nuclei and cytoplasmic compartment) was only present in a small subset of CRPC bone metastases. Mitochondrial sequencing from different metastases in a CRPC patient provided evidence for the seeding of metastases from previously established metastases, highlighting the biological relevance of EMT-like behavior in CRPC metastases.

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“…[5] This protein is mainly expressed in the cytoplasm and plasma membrane and is upregulated in response to lesions. [20,21] Ishimine et al, found that N-cadherin can serve as a prospective marker on the plasma membrane of human mesenchymal stem cells, as it may promote the differentiation of cardiomyocytes. When cardiomyogenic progenitor cells differentiate into mature cardiomyocytes, high levels of N-cadherin expression are observed, which play an essential role for the formation of cardiac intercalated disk structure.…”

Section: N-cadherinmentioning

confidence: 99%

The significance of cadherin for cell–cell interactions and cell adhesions on biomaterials

Shen

et al. 2015

Journal of Adhesion Science and Technology

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Cadherins are surface glycoproteins on plasma membranes and exist in many forms: T-cadherin, neuronal cadherin (N-cadherin), epithelial cadherin (E-cadherin), and vascular endothelial (VE-cadherin). Cadherins play critical roles in cell-cell interactions and are involved in multiple functions related to cell growth and proliferation. Findings from numerous reports have indicated that VE-cadherin regulates the remodeling, gating, and maturation of vascular vessels. The surface morphology of materials also impacts endothelial cell adhesion. This report is an overview of recent research on the effects of cadherins on cell-cell interactions, along with cell adhesions as examined on different materials. This summary will provide novel insights and approaches for research on cell-cell and cell-material interactions and illuminate some of the mechanisms of cell growth on different materials.

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Expression and significance of E-cadherin, N-cadherin, transforming growth factor-β1 and Twist in prostate cancer

Abstract: The reduced expression of E-cadherin, abnormal expression of N-cadherin, transformation form E-cadherin to N-cadherin and the increased expression of TGF-β1 and Twist play an important role in the occurrence and development of prostate cancer.

Cited by 43 publications

References 21 publications

Assessment of Vitronectin, Soluble Epithelial-Cadherin and TGF-β1 as a Serum Biomarker with Predictive Value for Endometrial and Ovarian Cancers

Assessment of Vitronectin, Soluble Epithelial-Cadherin and TGF-β1 as a Serum Biomarker with Predictive Value for Endometrial and Ovarian Cancers

Epithelial mesenchymal-like transition occurs in a subset of cells in castration resistant prostate cancer bone metastases

The significance of cadherin for cell–cell interactions and cell adhesions on biomaterials

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