Expression and Significance of KIM-1, NGAL, and HO-1 in Patients with Acute Kidney Injury After Cardiac Valve Replacement

Abstract

Objective To investigate the changes and significance of perioperative expression levels of kidney injury molecule-1 (KIM-1), neutrophil gelatinase-related lipocalin (NGAL), and heme oxygenase-1 (HO-1) in patients with acute kidney injury (AKI) after cardiac valve replacement under cardiopulmonary bypass. Methods A total of 80 patients were divided into the AKI group and non-AKI group based on the postoperative occurrence of AKI. The expression levels of urinary KIM-1, NGAL, serum creatinine, urea nitrogen, and HO-1 were compared between the two groups before surgery and at 12 h, 24 h, and 48 h after surgery. Results There were 22 patients with postoperative AKI (AKI group), the incidence of postoperative AKI were 27.5%, and there were 58 patients without AKI (non-AKI group). There was no significant difference in general clinical data between the two groups ( P > 0.05). Compared between AKI group and preoperative group, KIM-1, NGAL, HO-1, blood creatinine, and BUN levels were significantly increased, with significant differences ( P < 0.05). Compared with non-AKI groups, KIM-1, NGAL, HO-1, blood creatinine, and blood urea nitrogen levels increased at all time points, but the difference was not significant ( P > 0.05). Compared with AKI group and non-AKI group, KIM-1, NGAL, HO-1, blood creatinine, and BUN levels increased significantly, the differences were statistically significant ( P < 0.05). Conclusion AKI can easily occur after cardiac valve replacement and postoperative expression levels of KIM-1, NGAL, and HO-1 can be early warning indicators of postoperative AKI.

Cerium–Luteolin Nanocomplexes in Managing Inflammation-Related Diseases by Antioxidant and Immunoregulation

“…Simultaneously, we assessed the levels of heme oxygenase-1 (HO-1) and kidney injury molecule-1 (KIM-1), which are well-known biomarkers associated with kidney injury, in the kidney tissues. 45 Following the administration of CeLutNCs, the levels of HO-1 and KIM-1 in the kidneys of AKI mice were restored to levels similar to those observed in healthy mice (Figure 6c,d). Furthermore, we also monitored the levels of 8hydroxy-2′-deoxyguanosine (8-OHdG), a well-established biomarker for DNA damage.…”

“…Notably, at a dosage of 1.5 mg kg –1 , the number of apoptotic cells was the lowest, highlighting the excellent anti-apoptotic effect of CeLutNCs. Simultaneously, we assessed the levels of heme oxygenase-1 (HO-1) and kidney injury molecule-1 (KIM-1), which are well-known biomarkers associated with kidney injury, in the kidney tissues . Following the administration of CeLutNCs, the levels of HO-1 and KIM-1 in the kidneys of AKI mice were restored to levels similar to those observed in healthy mice (Figure c,d).…”

Mechanism and clinical role of TIMP-2 and IGFBP-7 in cardiac surgery-associated acute kidney injury: A review

“…It is produced by tubular cells and neutrophils to diagnose the severity of AKI. [12,13] L-FABP, a 14 kDa intracellular lipid chaperone produced by proximal tubule help diagnose AKI. [14] KIM-1, a type of transmembrane glycoprotein released into urine, which predicted and identify the severity of AKI.…”