1992
DOI: 10.1073/pnas.89.12.5601
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Expression cloning of a cDNA from rabbit kidney cortex that induces a single transport system for cystine and dibasic and neutral amino acids.

Abstract: We have isolated a cDNA clone by screening a rabbit kidney cortex cDNA library for expression of sodiumindependent transport of L-arginine and L-alanine in Xenopus laevis oocytes. Expressed uptake relates to a single component of sodium-independent transport for dibasic and neutral amino acids. This transport activity resembles the functionally defined system b0'+ and carries cystine and dibasic amino acids with high affmity. The rBAT (bO'+ amino acid transporterrelated) mRNA is found mainly in kidney and inte… Show more

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Cited by 208 publications
(178 citation statements)
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“…This agrees with previous studies that reported a transcript of similar size detected by Northern blot with rabbit or rat rBAT cDNA probes (27,28). Crossreaction with the homologous cell surface antigen 4F2hc transcript seems to be ruled out, since no hybridization signal was obtained in OK cells mRNA using a human 4F2hc cDNA (37) probe (data not shown).…”
Section: Ok Cellssupporting
confidence: 81%
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“…This agrees with previous studies that reported a transcript of similar size detected by Northern blot with rabbit or rat rBAT cDNA probes (27,28). Crossreaction with the homologous cell surface antigen 4F2hc transcript seems to be ruled out, since no hybridization signal was obtained in OK cells mRNA using a human 4F2hc cDNA (37) probe (data not shown).…”
Section: Ok Cellssupporting
confidence: 81%
“…These cells express an mRNA transcript that hybridizes with rBAT probes (27,28), and they show high affinity sodiumindependent cystine-dibasic amino acid transport in the apical pole (31). Here we demonstrate that OK cells express rBAT mRNA and that the transport of cystine in the apical pole of these cells is due to an amino acid transport system very similar to the b 0,ϩ -like system elicited by rBAT in oocytes.…”
Section: The Nucleotide Sequence(s) Reported In This Paper Has Been Smentioning
confidence: 72%
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