Expression level of sonic hedgehog correlated with the speed of gastric mucosa regeneration in artificial gastric ulcers

Abstract

Expression of Shh was correlated with the speed of gastric ulcer healing, promoting the regeneration of gastric mucosa.

Two-week treatment with proton pump inhibitor is sufficient for healing post endoscopic submucosal dissection ulcers

“…The use of rebamipide might eliminate the distinction in healing rate between the 2W and 4W groups. But, in our previous report, we treated 45 artificial ulcers after ESD only by PPI (esomeprazole or omeprazole) for 4 wk and showed that the healing rate was 94.6% (95%CI: 90.7%-98.5%), which was not different from those of 2W or 4W groups in this study [23] . This result suggested us that the effect of adding rebamipide on healing ulcer was limited.…”

“…Rebamipide has been reported to induce healing of ulcers, especially artificial ulcers [14] . Nishizawa et al [22] reported that the administration of rebamipide could induce the expression of Sonic Hedgehog (Shh) and we also reported that the expression level of Shh in the gastric mucosa showed a good correlation with the speed of healing of artificial ulcers [23] , that is, rebamipide could promote the healing of ulcers via Shh, which could influence some cellular and tissue functions, including cell proliferation and tissue repair [24,25] . The use of rebamipide might eliminate the distinction in healing rate between the 2W and 4W groups.…”

Vonoprazan is superior to proton pump inhibitors in healing artificial ulcers of the stomach post‐endoscopic submucosal dissection: A propensity score‐matching analysis

“…It has been reported that rebamipide could heal artificial ulcers rapidly because it could induce the expression of Sonic Hedgehog (Shh) . We have also reported that the Shh expression level in the gastric mucosa showed a high correlation with the healing speed of artificial ulcers of the stomach post‐ESD . Because Shh could influence some cellular and tissue functions, including cell proliferation and tissue repair, rebamipide may enhance the healing of ulcers.…”

“…34 We have also reported that the Shh expression level in the gastric mucosa showed a high correlation with the healing speed of artificial ulcers of the stomach post-ESD. 35 Because Shh could influence some cellular and tissue functions, including cell proliferation and tissue repair, 36,37 rebamipide may enhance the healing of ulcers. There have been several randomized controlled trials (RCT) comparing the effects of PPI alone and rebamipide adjunctively with PPI for artificial ulcer, and all results support rebamipide adjunctively.…”

Enhancement of Gastric Ulcer Healing and Angiogenesis by Hepatocyte Growth Factor Gene Mediated by AttenuatedSalmonellain Rats

“…At present, nearly 15 million people are suffering from peptic ulcer diseases, and almost 6,000 people die of it every year. Gastric ulcer healing is a complex process that involves inflammation, reepithelialization, granulation tissue formation, angiogenesis, and scar formation (123). The approaches to the treatment of gastric ulcer includes inhibition of gastric acid secretion by H 2 receptor blockers or proton pump inhibitors (PPIs) as well as eradication of H. pylori (4).…”