Expression level of valosin-containing protein (VCP) as a prognostic marker for gingival squamous cell carcinoma

Yamamoto, Shinji; Tomita, Yoshihiro; Hoshida, Yoshihiko; Toyosawa, Satoru; Inohara, Hidenori; Kishino, Mitsunobu; Kogo, Mikihiko; Nakazawa, M; Murakami, Shumei; Iizuka, Norishige; Kidogami, Shinya; Monden, Morito; Kubo, Takeshi; Ijuhin, Naokuni; Aozasa, Katsuyuki

doi:10.1093/annonc/mdh354

Cited by 32 publications

(21 citation statements)

References 12 publications

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“…It has been shown that VCP was an independent prognostic factor for both of OS and DFS by removing PBX2 factor (data not shown). This agrees with Yamamoto et al (2004a)'s study. Therefore, PBX2 is a stronger prognostic factor than VCP in GSCC.…”

Section: Discussionsupporting

confidence: 93%

“…The previous study also showed that the level of valosin-containing protein (VCP) expression, which is involved in invasion and metastasis of cancers, is correlated with metastatic potential in tumor cells and poor prognosis in many kinds of cancers, including GSCC (Yamamoto et al, 2003;2004a;2004b;2004c). The PBX2 expression is correlated with VCP expression, which has been revealed in NSCLC cell lines and in the clinical samples.…”

Section: Introductionmentioning

confidence: 91%

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Expression level of pre-B-cell leukemia transcription factor 2 (PBX2) as a prognostic marker for gingival squamous cell carcinoma

Qiu

Wang

Jin

et al. 2012

J. Zhejiang Univ. Sci. B

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Abstract:Objective: In this study, we investigated the interrelationship between clinicopathologic findings and pre-B-cell leukemia transcription factor 2 (PBX2) expression in gingival squamous cell carcinoma (GSCC). Methods: Expression level of PBX2 was immunohistochemically examined in 66 GSCC subjects (30 men and 36 women) with ages ranging from 42 to 85 (median 64.5) years, in which staining intensity in tumor cells was categorized as either weaker (level 1) or equal to/stronger (level 2) than that in the endothelial cells. Results: PBX2 expression is correlated with valosin-containing protein (VCP) expression. Univariate and multivariate analyses revealed a high level of PBX2 expression to be a poor prognosticator for disease-free survival (DFS) and overall survival (OS), and PBX2 expression was an independent prognostic factor for both DFS and OS in GSCC. Conclusions: PBX2 expression level in GSCC is prognostic. PBX2 may be a useful marker to identify the potential for progression in GSCC.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 91%

Expression level of pre-B-cell leukemia transcription factor 2 (PBX2) as a prognostic marker for gingival squamous cell carcinoma

Qiu

Wang

Jin

et al. 2012

J. Zhejiang Univ. Sci. B

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“…14 In addition, VCP had already been associated with prognosis in other tumour entities by Yamamoto and co-workers. 10,[15][16][17][18][19][20] For the validation, a second independent case-control group was investigated by Western blot analysis. Median VCP expression of all samples in this group was 0.19 (0.12-0.40), whereas PGR showed a median VCP Valosin-containing protein in childhood ALL M Lauten et al expression of 0.15 (0.11-0.28) compared to 0.34 (0.14-0.99) in PPR (P ¼ 0.04).…”

Section: Resultsmentioning

confidence: 99%

Unsupervised proteome analysis of human leukaemia cells identifies the Valosin-containing protein as a putative marker for glucocorticoid resistance

et al. 2006

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The response to initial glucocorticoid therapy in childhood acute lymphoblastic leukaemia (ALL) reliably predicts the response to multiagent chemotherapy. Patients resistant to glucocorticoids (prednisone poor responders (PPR)) have a poorer event-free survival compared to glucocorticoid-sensitive patients (prednisone good responders (PGR)). A casecontrol study was performed to investigate differential protein expression in leukaemic blasts from PGR and PPR childhood ALL patients. Two-dimensional gel electrophoresis (2-DE) was used for an unsupervised screening and surface enhanced laser desorption/ionisation-time of flight mass spectrometry (SELDI-TOF MS) for the characterisation of protein spots. In difference maps of average gels for the proteomes of each responder group, differentially expressed proteins were identified after tryptic digestion and spotting onto H4-SELDI-TOF-MS chips. Proteins overexpressed in PPR were Catalase, RING finger protein 22 alpha, Valosin-containing protein (VCP) and a G-protein-coupled receptor. Proteins overexpressed in PGR were protein kinase C and malate dehydrogenase. Valosincontaining protein was chosen for validation and quantification by Western blot analysis in a second case-control group of ALL patients. In this second independent cohort, median VCP expression (P 25 -P 75 ) was 0.15 (0.11-0.28) in PGR and 0.34 (0.14-0.99) in PPR patients (P ¼ 0.04). We conclude that high VCP expression is associated with poor prednisone response in childhood ALL patients.

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“…Those five silkworm genes meet all requirements for selenoproteins, although their homologs in other species do not. Proteins CG6024 and CG5195 do not have enough information at present, but ABCA and nuclear VCP-like protein are being studied by many groups [31][32][33][34][35][36][37] .…”

Section: Discussionmentioning

confidence: 99%

“…It constitutes a family of highly conserved proteins involved in the membrane transport of a variety of substrates including ions, amino acids, peptides, sugars, vitamins and steroid hormones [31 -34] . VCP, a member of the superfamily of ATPases associated with various cellular activities (AAA), is known to be involved in proteasome degradation pathway of inhibitor κBα (IκBα), an inhibitor of nuclear factor-κB (NFκB) [35,36] . Cell lines transfected with VCP showed the constant activation of NFκB and rapid degradation of phosphorylated IκBα [37] .…”

Section: Discussionmentioning

confidence: 99%

In silico identification of silkworm selenoproteomes

et al. 2006

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Selenium (Se) is an essential trace element in vivo. Its biological function is mainly exerted through selenoproteins. Selenocysteine (Sec), the active site of selenoproteins, is incorporated into the protein at an in-frame TGA codon under the guidance of Sec insertion sequence (SECIS) element in the 3′-untranslated region (UTR) of the gene. In this work, a method was developed and a series of programs were edited by PERL language to in silico identify selenoproteomes from the genome of domesticated silkworm (Bombyx mori). Out of 18510 annotated genes, 6348 was terminated with TGA codons, 249 containing both in-frame TGAs and SECIS elements in the 3′-UTRs. Alignments of those selenoprotein candidates with their cysteine (Cys)-containing homologs revealed that 52 genes had TGA/Cys pairs and similar flanking regions around the in-frame TGAs. Restricted by the patterns of SECIS elements only 5 genes were screened out to fully meet the requirements for selenoproteins. Among them glutathione S-transferase (GST) has been reported as a microbial selenoprotein, the other four are novel selenoproteins annotated as CG6024, CG5195, ATP-binding cassette transporter subfamily A (ABCA), and nuclear VCP-like protein. Derived from the general properties of GST, ABCA and VCP, silkworm selenoproteins may play important roles in redox regulation, Se storage and transportation, as well as cell apoptosis.

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Expression level of valosin-containing protein (VCP) as a prognostic marker for gingival squamous cell carcinoma

Abstract: Prognostic significance of VCP expression level in GSCC was demonstrated.

Cited by 32 publications

References 12 publications

Expression level of pre-B-cell leukemia transcription factor 2 (PBX2) as a prognostic marker for gingival squamous cell carcinoma

Expression level of pre-B-cell leukemia transcription factor 2 (PBX2) as a prognostic marker for gingival squamous cell carcinoma

Unsupervised proteome analysis of human leukaemia cells identifies the Valosin-containing protein as a putative marker for glucocorticoid resistance

In silico identification of silkworm selenoproteomes

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