Expression levels of breast cancer-related<i>GAS5</i>and<i>LSINCT5</i>lncRNAs in cancer-free breast tissue: Molecular associations with age at menarche and obesity

Mansoori, Yaser; Tabei, Mohammad Bagher; Askari, Alireza; Izadi, Pantea; Daraei, Abdolreza; Bastami, Milad; Naghizadeh, Mohammad Mehdi; Nariman‐Saleh‐Fam, Ziba; Mansoori, Behnam; Tavakkoly‐Bazzaz, Javad

doi:10.1111/tbj.13067

Cited by 25 publications

(25 citation statements)

References 36 publications

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“…Long et al [18] demonstrated that ovarian cancer patients with high LSINCT5 expression tended to have advanced FIGO stage and lymph node metastasis. However, Mansoori et al [19] indicated there was no significant correlation between LSINCT5 expression and clinicopathological characteristics in breast cancer patients.…”

Section: Discussionmentioning

confidence: 99%

LSINCT5 predicts unfavorable prognosis and exerts oncogenic function in osteosarcoma

Ming

Dongbo

2019

Bioscience Reports

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The dysregulated expression of LSINCT5 (long stress-induced non-coding transcript 5) has been found in various human tumors, and was generally related to cancer progression and unfavorable prognosis. Although the role of LSINCT5 in osteosarcoma was reported not long ago, the sample size of that study was limited. Our study presented more evidence about the clinical significance and biological function of LSINCT5 in osteosarcoma. In our results, we found LSINCT5 expression was increased in osteosarcoma tissue samples and cell lines, and high LSINCT5 expression was associated with advanced Enneking stage, large tumor size, high histological grade and present distant metastasis. Meanwhile, we observed high LSINCT5 expression was correlated with worse overall survival, and high LSINCT5 expression could be an independent poor predictor for overall survival in osteosarcoma cases. Moreover, we found inhibition of LSINCT5 expression suppressed cell proliferation, migration and invasion in vitro, and LSINCT5 overexpression dramatically facilitated cell proliferation, migration and invasion in vitro. In conclusion, our study suggests that LSINCT5 exerts oncogenic function in osteosarcoma cells, and may be a potential predictor for clinical outcome in osteosarcoma patients.

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Section: Discussionmentioning

confidence: 99%

LSINCT5 predicts unfavorable prognosis and exerts oncogenic function in osteosarcoma

Ming

Dongbo

2019

Bioscience Reports

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“…Recent studies examined GAS5 expression in a variety of cancers [33] including breast, bladder, ovarian, and cervical carcinomas [30,31,32,34,35,36,37,38,39,40], with a focus on cell proliferation and apoptosis. Other publications on the lncRNA GAS5 address not only proliferation but cell migration and tumor cell invasion.…”

Section: Gas5 Expression In Cancersmentioning

confidence: 99%

The Growth-Arrest-Specific (GAS)-5 Long Non-Coding RNA: A Fascinating lncRNA Widely Expressed in Cancers

Goustin

Thepsuwan

Kosir

et al. 2019

ncRNA

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Long non-coding RNA (lncRNA) genes encode non-messenger RNAs that lack open reading frames (ORFs) longer than 300 nucleotides, lack evolutionary conservation in their shorter ORFs, and do not belong to any classical non-coding RNA category. LncRNA genes equal, or exceed in number, protein-coding genes in mammalian genomes. Most mammalian genomes harbor ~20,000 protein-coding genes that give rise to conventional messenger RNA (mRNA) transcripts. These coding genes exhibit sweeping evolutionary conservation in their ORFs. LncRNAs function via different mechanisms, including but not limited to: (1) serving as “enhancer” RNAs regulating nearby coding genes in cis; (2) functioning as scaffolds to create ribonucleoprotein (RNP) complexes; (3) serving as sponges for microRNAs; (4) acting as ribo-mimics of consensus transcription factor binding sites in genomic DNA; (5) hybridizing to other nucleic acids (mRNAs and genomic DNA); and, rarely, (6) as templates encoding small open reading frames (smORFs) that may encode short proteins. Any given lncRNA may have more than one of these functions. This review focuses on one fascinating case—the growth-arrest-specific (GAS)-5 gene, encoding a complicated repertoire of alternatively-spliced lncRNA isoforms. GAS5 is also a host gene of numerous small nucleolar (sno) RNAs, which are processed from its introns. Publications about this lncRNA date back over three decades, covering its role in cell proliferation, cell differentiation, and cancer. The GAS5 story has drawn in contributions from prominent molecular geneticists who attempted to define its tumor suppressor function in mechanistic terms. The evidence suggests that rodent Gas5 and human GAS5 functions may be different, despite the conserved multi-exonic architecture featuring intronic snoRNAs, and positional conservation on syntenic chromosomal regions indicating that the rodent Gas5 gene is the true ortholog of the GAS5 gene in man and other apes. There is no single answer to the molecular mechanism of GAS5 action. Our goal here is to summarize competing, not mutually exclusive, mechanistic explanations of GAS5 function that have compelling experimental support.

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“…[21]. Moreover, these small noncoding RNAs not only play an important role in BC development, but also have some links with BC risk factors in breast tissue of healthy women [22,23]. And interestingly, lncRNAs have been shown to exhibit diagnostic and prognostic biomarker properties as well as therapeutic targets for BC [24].…”

Section: Discussionmentioning

confidence: 99%

Clinical Values of two Novel Estrogen Receptor Signaling Targeted lncRNAs in Invasive ductal breast carcinoma

Ilbeigi

Farahani

Monjezi

et al. 2020

Preprint

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Invasive ductal carcinoma (IDC) is the most frequent type of breast cancer (BC) in women, with a high clinical burden due to its high invasive properties. Despite of new data regarding the molecular heterogeneity of invasive cancers is quickly emerging; far less is known about the molecular patterns among cases of IDC. An expanding body of evidence has demonstrated that dysregulation of long noncoding RNAs (lncRNAs) is involved in heterogeneity feature of the BC. In this study, we analyzed the expression levels of two novel lncRNAs LOC100288637 and RP11-48B3 in 51 IDC tissues in comparison with adjacent non-cancerous tissues (ANCTs). And finally, bioinformatic evaluation has been done.The qPCR results showed that LOC100288637 and RP11-48B3 were significantly overexpressed in tumor tissues compared to normal samples (P= 0.0085 and P= 0.0002, respectively). Also, the two lncRNAs were overexpressed in both MDA-MB-231 and MCF-7 BC cell lines, nevertheless, with a higher expression pattern in MDA-MB-231 than MCF7 cell line. Furthermore, LOC100288637 had an elevated expression level in HER-2 positive tumors compared to HER-2 negative tumors (P= 0.031). Interestingly, the lncRNA RP11-48B3.4 was upregulated in IDC subjects with age at menarche <14 compared to patients with age at menarche ≥14 (P= 0.041). It was observed in another result that lncRNA RP11-48B3.4 is significantly upregulated in tumors with a lower histological grade compared to tumor samples with higher grades (P= 0.047). And finally, using bioinformatic evaluation, we found a predicted interaction between RP11-48B3.4 and mRNA Zinc Finger and BTB Domain Containing 10 (ZBTB10).Altogether, our findings suggest that these lncRNAs with potential oncogenic roles involved in pathogenesis of IDC with clinical significance, and thus, they may serve as novel markers for diagnosis and treatment of IDC.

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Expression levels of breast cancer-relatedGAS5andLSINCT5lncRNAs in cancer-free breast tissue: Molecular associations with age at menarche and obesity

Cited by 25 publications

References 36 publications

LSINCT5 predicts unfavorable prognosis and exerts oncogenic function in osteosarcoma

LSINCT5 predicts unfavorable prognosis and exerts oncogenic function in osteosarcoma

The Growth-Arrest-Specific (GAS)-5 Long Non-Coding RNA: A Fascinating lncRNA Widely Expressed in Cancers

Clinical Values of two Novel Estrogen Receptor Signaling Targeted lncRNAs in Invasive ductal breast carcinoma

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