Expression Levels of Vascular Endothelial Growth Factors A and C in Patients with Peptic Ulcers and Gastric Cancer

Taghizadeh, S; Sankian, Mojtaba; Ajami, Abolghasem; Tehrani, Mohsen; Hafezi, Nasim; Mohammadian, Rajeeh; Farazmandfar, Touraj; Hosseini, Vahid; Abbasi, Ali; Ajami, Maryam

doi:10.5230/jgc.2014.14.3.196

Cited by 8 publications

(5 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, several determinants in GC development such as vascular endothelial growth factor-A and -C (VEGFA and VEGFC) were shown to be overexpressed in H . pylori -positive GC patients and their clinical significances were investigated ( 11 ). However, despite all these efforts to identify only a limited number of GC tissue-based biomarkers with prognostic values for H .…”

Section: Introductionmentioning

confidence: 99%

High expression of GNB4 predicts poor prognosis in patients with Helicobacter pylori-positive advanced gastric cancer

Gao¹,

Teng²,

Yao³

et al. 2020

Transl Cancer Res TCR

View full text Add to dashboard Cite

Background Helicobacter pylori ( H. pylori ) is recognized as the most evident etiologic factor of infection-related gastric cancer (GC) and its involvement in GC initiation and progression has been well investigated. However, only a limited number of studies were performed to identify prognostic biomarkers and evaluate their clinical significance in GC patients infected with H. pylori . This study was conducted to investigate the clinical significance as well as its potential prognostic value of GNB4 in H. pylori -positive GC patients receiving standard treatment. Methods Retrospective statistical analysis was performed on 448 H. pylori -positive GC patients, with 137 early gastric cancer (EGC) patients undergoing radical gastrectomy alone and 311 advanced gastric cancer (AGC) patients receiving the same surgical procedure followed by fluorouracil-based chemotherapy. GNB4 expression was detected by immunohistochemistry staining on patient samples. H. pylori infection was routinely examined on endoscopic biopsy and/or surgical specimen of GC patients. Results High expression of GNB4 was 65.7% (90/137) in EGC and 62.7% (195/311) in AGC patients infected with H. pylori , respectively. In EGC patients, GNB4 expression was not associated with either clinicopathological parameters or 5-year overall survival (OS). In AGC patients however, high expression of GNB4 was significantly associated with patient’s pathological stage (P=0.047). Univariate analysis showed that tumor invasion depth (P=0.001), lymph node metastasis (P<0.001), pathological stage (P<0.001) as well as high expression of GNB4 (P=0.002) were significantly associated with 5-year OS. Multivariate analysis further identified lymph node metastasis (P=0.013) and GNB4 high expression (P=0.020) as independent prognostic factors for long-term outcome of H. pylori -positive AGC patients. Conclusions This study demonstrates that high expression of GNB4 is significantly associated with pathological stage of AGC patients with H. pylori infection. GNB4 expression independently predicts the 5-year OS of H. pylori -positive AGC patients undergoing radical gastrectomy and adjuvant chemotherapy.

show abstract

Section: Introductionmentioning

confidence: 99%

High expression of GNB4 predicts poor prognosis in patients with Helicobacter pylori-positive advanced gastric cancer

Gao¹,

Teng²,

Yao³

et al. 2020

Transl Cancer Res TCR

View full text Add to dashboard Cite

show abstract

“…Gram staining. Oxidase and catalase tests 13 GC: 2 tissues at an early stage and 11 tissues at an advanced stage; 6 intestinal type tissues, 4 diffuse type tissues, and 3 mixed type tissues Pathological diagnosis 32.5 (18.57 to 49.13) Yu et al [ 132 ] China 1992 -2007 2014 CS 217 59.15 IHC -PCR 116 intestinal type:97, diffuse type: 95 Histopathology 53.46 (46.58 to 60.24) Zabaglia et al [ 45 ] Brazil - 2017 PCS 72 65,6 PCR 19 GC Histopathology 26.39 (16.7 to 38.1) Szkaradkiewicz et al [ 46 ] Poland 2013–2014 2016 CS 42 65 PCR 15 GC Histopathology 35.71 (21.55 to 51.97) Jorge et al [ 47 ] Brazil - 2013 PCS 27 63.4 Multiplex PCR 11 Intestinal: 12 Diffuse type: 8 Histopathology 40.74 (22.39 to 61.2) Taghizadeh et al [ 48 ] Iran 2012 -2013 ...…”

Section: Resultsmentioning

confidence: 99%

The global prevalence of gastric cancer in Helicobacter pylori-infected individuals: a systematic review and meta-analysis

Shirani,

Pakzad,

Haddadi

et al. 2023

BMC Infect Dis

View full text Add to dashboard Cite

Background Helicobacter pylori is a gastrointestinal pathogen that infects around half of the world's population. H. pylori infection is the most severe known risk factor for gastric cancer (GC), which is the second highest cause of cancer-related deaths globally. We conducted a systematic review and meta-analysis to assess the global prevalence of GC in H. pylori-infected individuals. Methods We performed a systematic search of the PubMed, Web of Science, and Embase databases for studies of the prevalence of GC in H. pylori-infected individuals published from 1 January 2011 to 20 April 2021. Metaprop package were used to calculate the pooled prevalence with 95% confidence interval. Random-effects model was applied to estimate the pooled prevalence. We also quantified it with the I2 index. Based on the Higgins classification approach, I2 values above 0.7 were determined as high heterogeneity. Results Among 17,438 reports screened, we assessed 1053 full-text articles for eligibility; 149 were included in the final analysis, comprising data from 32 countries. The highest and lowest prevalence was observed in America (pooled prevalence: 18.06%; 95% CI: 16.48 − 19.63; I2: 98.84%) and Africa (pooled prevalence: 9.52%; 95% CI: 5.92 − 13.12; I2: 88.39%). Among individual countries, Japan had the highest pooled prevalence of GC in H. pylori positive patients (Prevalence: 90.90%:95% CI: 83.61–95.14), whereas Sweden had the lowest prevalence (Prevalence: 0.07%; 95% CI: 0.06–0.09). The highest and lowest prevalence was observed in prospective case series (pooled prevalence: 23.13%; 95% CI: 20.41 − 25.85; I2: 97.70%) and retrospective cohort (pooled prevalence: 1.17%; 95% CI: 0.55 − 1.78; I 2: 0.10%). Conclusions H. pylori infection in GC patients varied between regions in this systematic review and meta-analysis. We observed that large amounts of GCs in developed countries are associated with H. pylori. Using these data, regional initiatives can be taken to prevent and eradicate H. pylori worldwide, thus reducing its complications.

show abstract

“…pylori -induced ulcers 26 . Meanwhile, recent evidence has suggested that elevated expression levels of endothelial growth factor C in gastric mucosal inflammation induced by sleep apnea, sleep loss, and nighttime hypoxia are likely to increase the risk of developing PUD 27,28 .…”

Section: Discussionmentioning

confidence: 99%

Association between Poor Sleep Quality and Subsequent Peptic Ulcer Recurrence in Older Patients with Mild Cognitive Impairment: Examining the Role of Social Engagement

Fang

Yang

et al. 2019

Sci Rep

View full text Add to dashboard Cite

This study aims to examine whether perceived poor sleep quality predicts subsequent recurrence of peptic ulcer disease (PUD) in older patients with mild cognitive impairment following Helicobacter pylori eradication and to investigate whether social engagement status alters this association. Of 1,689 older patients with H. pylori-infected PUD recruited from eight Grade-A hospitals in the People’s Republic of China between 2011 and 2014, H. pylori was eradicated and PUD cleared in 1,538 patients by the end of 2014; 1,420 of these were followed for up to 36 months. The Kaplan–Meier method was used to compare the proportion of PUD recurrence, as confirmed with esophagogastroduodenoscopy, among older patients with different levels of sleep quality and social engagement statuses. Multivariate Cox-proportional hazards models were performed to examine the association between sleep quality and PUD recurrence, and the role of social engagement in altering this relationship. The results showed that PUD recurrence was more prevalent in poor (10.8%) compared with good sleepers (5.5%). However, increased and continued social engagement reduced the proportion to 7.2% and 8.2% among poor sleepers, respectively. Poor sleep quality was associated with subsequent PUD recurrence (hazard ratio [HR] 1.965 (1.002, 3.518)). However, no significant difference was observed between good and poor sleepers who reported increased (HR 1.428 (0.736, 2.380)) and continued (HR 1.273 (0.915, 2.492)) social engagement, suggesting that increased and continued social engagement prevented the effect of poor sleep quality on PUD recurrence. To conclude, poor sleep quality is associated with subsequent PUD recurrence. However, increased and continued social engagement may moderate this association.

show abstract

Expression Levels of Vascular Endothelial Growth Factors A and C in Patients with Peptic Ulcers and Gastric Cancer

Cited by 8 publications

References 33 publications

High expression of GNB4 predicts poor prognosis in patients with Helicobacter pylori-positive advanced gastric cancer

High expression of GNB4 predicts poor prognosis in patients with Helicobacter pylori-positive advanced gastric cancer

The global prevalence of gastric cancer in Helicobacter pylori-infected individuals: a systematic review and meta-analysis

Association between Poor Sleep Quality and Subsequent Peptic Ulcer Recurrence in Older Patients with Mild Cognitive Impairment: Examining the Role of Social Engagement

Contact Info

Product

Resources

About