Expression of 15‐lipoxygenase‐1 in Merkel cell carcinoma is linked to advanced disease

Fochtmann-Frana, Alexandra; Haymerle, Georg; Schachner, Helga; Pammer, Johannes; Loewe, Robert; Kerjaschki, Dontscho; Perisanidis, Christos; Erovic, Boban M.

doi:10.1111/coa.13191

Cited by 4 publications

(3 citation statements)

References 47 publications

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“…Our data suggest that SATB2 and MAP2 downregulated expression is correlated with promoter DNA hypermethylation, while downregulated ALOX5 expression correlates with gene body DNA hypomethylation (Fig. 6 A) [ 90 – 92 ]. Furthermore, overexpression of CDKN2A, NCAM1, PAX5, and PDGFRA in MCC can be indicated by DNA hypermethylation of their gene bodies (Fig.…”

Section: Resultsmentioning

confidence: 94%

Characterizing DNA methylation signatures and their potential functional roles in Merkel cell carcinoma

Gujar

Mehta

et al. 2021

Genome Med

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Background Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer with limited treatment possibilities. Merkel cell tumors display with neuroendocrine features and Merkel cell polyomavirus (MCPyV) infection in the majority (80%) of patients. Although loss of histone H3 lysine 27 trimethylation (H3K27me3) has been shown during MCC tumorigenesis, epigenetic dysregulation has largely been overlooked. Methods We conducted global DNA methylation profiling of clinically annotated MCC primary tumors, metastatic skin tumors, metastatic lymph node tumors, paired normal tissues, and two human MCC cell lines using the Illumina Infinium EPIC DNA methylation BeadArray platform. Results Significant differential DNA methylation patterns across the genome are revealed between the four tissue types, as well as based on MCPyV status. Furthermore, 964 genes directly regulated by promoter or gene body DNA methylation were identified with high enrichment in neuro-related pathways. Finally, our findings suggest that loss of H3K27me3 occupancy in MCC is attributed to KDM6B and EZHIP overexpression as a consequence of promoter DNA hypomethylation. Conclusions We have demonstrated specific DNA methylation patterns for primary MCC tumors, metastatic MCCs, and adjacent-normal tissues. We have also identified DNA methylation markers that not only show potential diagnostic or prognostic utility in MCC management, but also correlate with MCC tumorigenesis, MCPyV expression, neuroendocrine features, and H3K27me3 status. The identification of DNA methylation alterations in MCC supports the need for further studies to understand the clinical implications of epigenetic dysregulation and potential therapeutic targets in MCC.

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Section: Resultsmentioning

confidence: 94%

Characterizing DNA methylation signatures and their potential functional roles in Merkel cell carcinoma

Gujar

Mehta

et al. 2021

Genome Med

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“…CISD1 expression is associated with tumor growth and is a potential therapeutic target (18). ALOX15 may also be a potential target for cancer treatment, and its expression level can be used as a predictive marker for the clinical outcome of patients with lymph node metastasis and malignant tumors (19). CARS1 participates in cysteine metabolism and is the rate-limiting agent in glutathione synthesis.…”

Section: Discussionmentioning

confidence: 99%

Analysis and prediction model of ferroptosis related genes in breast cancer

Wang¹,

Chen²,

Zhao³

et al. 2022

Transl Cancer Res TCR

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Background: The prognosis of patients with breast cancer (BRCA) is difficult to predict because of the high degree of heterogeneity and complex etiological factors. Ferroptosis, an iron-dependent, new form of cell death, plays an important role in regulation of tumor growth and progression. The aim of this study was to clarify the predictive value of ferroptosis-related genes in the overall survival of patients with BRCA. Methods:The messenger RNA expression profile and clinical information of patients with BRCA were collected from The Cancer Genome Atlas (TCGA) database. The differences between BRCA and adjacent normal tissues were analyzed, and candidates with differentially expressed ferroptosis-related genes were identified. Through Cox and LASSO analyses, the prognostic genetic characteristics of ferroptosis-related genes were established. Lastly, according to the median risk score, the patients were divided into high-risk and low-risk groups, a nomogram was constructed, and the prediction accuracy was tested.Results: It was determined that the four ferroptosis related genes had a significant difference in survival in BRCA (P<0.05); a prognostic model was constructed based on the four ferroptosis related genes, and the overall survival of patients in the high-risk group was significantly worse (P<0.05). The four-gene nomogram can quantify the contribution of each index to survival, and the calibration chart shows high prediction accuracy.Conclusions: This study constructed four ferroptosis related gene characteristics and nomogram, which can effectively predict the prognosis of BRCA patients and provide new insights for future anti-cancer treatments based on ferroptosis targets.

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“…We read with interest the recent article titled “Expression of 15‐lipoxygenase‐1 in Merkel cell carcinoma is linked to advanced disease” …”

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confidence: 99%

Letter to the Editor in reference to: Expression of 15‐lipoxygenase‐1 in Merkel cell carcinoma is linked to advanced disease

Narayanan

Doan²,

Simonette³

et al. 2018

Clinical Otolaryngology

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Expression of 15‐lipoxygenase‐1 in Merkel cell carcinoma is linked to advanced disease

Abstract: In the current study, we were able to show ALOX15 expression in the primary MCC sample and the metastasis sample. Based on the findings of the current study, expression rate of ALOX15 in primary MCC and metastases is possibly linked to an increased lymphatic vessel density.

Cited by 4 publications

References 47 publications

Characterizing DNA methylation signatures and their potential functional roles in Merkel cell carcinoma

Characterizing DNA methylation signatures and their potential functional roles in Merkel cell carcinoma

Analysis and prediction model of ferroptosis related genes in breast cancer

Letter to the Editor in reference to: Expression of 15‐lipoxygenase‐1 in Merkel cell carcinoma is linked to advanced disease

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