Expression of Activated Transcription Factor Nuclear Factor‐κB in Periodontally Diseased Tissues

Abstract

Activation of NF-kappaB (p50/p65) is significant in periodontally diseased tissues, suggesting the potential of inhibitors of NF-kappaB in managing periodontitis.

The 15-Deoxy-Δ12,14-prostaglandin J2 inhibits LPS-stimulated AKT and NF-κB activation and suppresses interleukin-6 in osteoblast-like cells MC3T3E-1

“…The nuclear factor-κB (NF-κB) has been proven to play a key role in the transcriptional up-regulation of the LPS-inducible IL-6 gene (Guha and Mackman 2001). Recent analysis of the localization of the NF-κB complex demonstrated markedly increased activity beneath periodontal lesions (Ambili et al 2005;Milward et al 2007). Therefore, NF-κB activation seems to be essential for LPS-stimulated osteoclastogenesis and bone resorption (Yip et al 2004).…”

Eugenol Modulates Cyclooxygenase-2 Expression Through the Activation of Nuclear Factor Kappa B in Human Osteoblasts

“…ROS generation is a strong inducer of NF-B translocation (25). The activation of NF-B has been linked with a variety of inflammatory diseases, including periodontitis (26). Whether the eugenol-induced activation of NF-B is through ROS generation remains to be elucidated.…”

Nuclear Factor-Kappa B: From Clone to Clinic

“…Several other diseases that are also linked with NF-B activation include acute pancreatitis [115], alcoholic hepatitis [116], anhidrotic ectodermal dysplasia [117], chronic infantile neurologic, chronic periodontitis [118], epidemic keratoconjunctivitis [119], hemodialysis [120], hypereosinophilic syndrome [121], mucositis [122], multiple organ dysfunction syndrome [123], Paget's disease of bone [124], severe trauma [125], and oral lichen planus [126] (Table 3).…”