Expression of AGR2 in pituitary adenomas and its association with tumor aggressiveness

Role of AGR2 Expression in Specimens from Pituitary Adenoma Tissue on Tumor Behavior

“…However, AGR2 expression was similar in the other adenomas compared to brain tissues. A similar result was observed in another study, and AGR2 expression was found more frequently in corticotroph and somatotroph adenomas (9). In the other study by the same researchers, the highest serum AGR2 level was observed in somatotrophic adenomas.…”

“…Future studies with tissues from cadavers will reveal more definitive results. The strength of this study lies in the establishment of a negative correlation between adenoma aggressiveness and AGR2 expression, which was similar to that observed in the two previous studies (9,10). This would play a significant role in determining the prognosis and individualized treatment in pituitary adenomas.…”

“…However, we found a negative association between AGR2 expression and aggressiveness in pituitary adenomas but these tumors are not malignant. Similar results were reported in two studies assessing AGR2 expression in pituitary adenomas (9,10). In the first study, AGR2 expression was assessed in pituitary adenoma tissues by immunohistochemical staining, and AGR2 staining was found to be negative in the majority of aggressive adenomas (9).…”

“…It has been reported that AGR2 overexpression may be associated with the development of various malignancies such as breast, lung, ovary, prostate, colon, and pancreas; however, there are controversial data on this topic (8). There are limited studies about the role of AGR2 expression in pituitary adenomas (9,10). In this study, the authors aimed to assess the importance of AGR2 expression in both identifying pituitary adenoma subtypes and tumor aggressiveness in tissue specimens from pituitary adenomas.…”

Leveraging the Role of the Metastatic Associated Protein Anterior Gradient Homologue 2 in Unfolded Protein Degradation: A Novel Therapeutic Biomarker for Cancer

“…The AGR2 protein was also shown to be highly expressed in pituitary adenoma (PA). The AGR2 expression levels were examined in 117 PA tissue samples using IHC and Western blotting, and 59 patients (51%) were shown to have an overexpressed AGR2 levels [71]. In a different study, AGR2 was variably detected in the serum of 163 PA patients using ELISA [72].…”