Expression of an antitumor–analgesic peptide from the venom of Chinese scorpion Buthus martensii karsch in Escherichia coli

Unique diversity of the venom peptides from the scorpion Androctonus bicolor revealed by transcriptomic and proteomic analysis

“…The amino acid sequences of AbNaTx2 and AbTx18 share 74% and 60% identities to those of AGAP and AGAP-SYPU2 from the scorpion M. martensii Karsch, respectively. AGAP and AGAP-SYPU2 possess analgesic and antitumor activities [75,76]. This suggests that AbNaTx2 and AbTx18 may have potential for the treatment of malignant glioma or acute pain.…”

Potent Modulation of the Voltage-Gated Sodium Channel Nav1.7 by OD1, a Toxin from the Scorpion Odonthobuthus doriae

“…A number of analgesic peptides from its venom have been reported; for most of them, it can be assumed that they could target VGSCs by virtue of their primary structure homology and similar scaffold with so-called long-chain sodium channel toxins (Goudet et al, 2002). They are: BmK ITAP, an excitatory insect-selective toxin (Xiong et al, 1999); BmK dITAP3, a depressant insect-selective toxin (Guan et al, 2001a) with an analgesic effect in mice; BmK AGAP, an antitumor analgesic peptide showing inhibitory effect on both visceral and somatic pain (Liu et al, 2003); BmK Ang P1 (Guan et al, 2001b); BmK AngM1 (Cao et al, 2004); BmK AS (Chen and Ji, 2002); BmK IT2 ; BmK I1; BmK I4; and BmK I6 (Guan et al, 2000). All of these are peptides for which analgesic properties in mice have been demonstrated.…”

Purification, characterization and functional expression of a new peptide with an analgesic effect from Chinese scorpion Buthus martensii Karsch (BmK AGP‐SYPU1)

“…The scorpion Buthus martensii Karsch (BmK) is a widely distributed species in China and has been used as a source of drugs for relieving pains caused by meningitis, cerebral palsy and rheumatism (Liu et al, 2003). In the first authoritative Chinese Pharmacopoeia Compendium of Materia Medica, edited by Li Shi-Zhen in 1578, the pharmaceutical properties and curative effects of the scorpion were described in detail.…”