Expression of an extracellular matrix metalloproteinase inducer (basigin) in the human ovary and ovarian endometriosis

Smedts, Anna M.; Lele, Subodh M.; Modesitt, Susan C.; Curry, Thomas E.

doi:10.1016/j.fertnstert.2006.01.042

Cited by 16 publications

(15 citation statements)

References 45 publications

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“…Additionally, lower levels of estrogen and progesterone have been noted in the serum and urine of women with endometriosis (Brosens et al 1978; Cheesman et al 1982; Cunha-Filho et al 2003; Smith et al 2002; Trinder and Cahill 2002; Tummon et al 1988). Changes in proteolytic enzymes (Ebisch et al 2007; Smedts et al 2006; Wunder et al 2005), cytokines (Carlberg et al 2000; Garrido et al 2000; Pellicer et al 1998; Wunder et al 2006), inflammatory molecules (Carlberg et al 2000; Lachapelle et al 1996; Wunder et al 2006) and the vasculature (Abae et al 1994; Garrido et al 2000; Pellicer et al 1998), all of which are required for normal ovulation, can also be found in the follicles of women with endometriosis. Collectively, these data provide evidence of mechanisms that could cause ovulatory dysfunction in endometriosis.…”

Section: Impact On the Ovarymentioning

confidence: 99%

Cellular and molecular basis for endometriosis-associated infertility

2012

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Endometriosis is a gynecological disease characterized by the presence of endometrial glandular epithelial and stromal cells growing in the extra-uterine environment. The disease afflicts 10%–15% of menstruating women causing debilitating pain and infertility. Endometriosis appears to affect every part of a woman’s reproductive system including ovarian function, oocyte quality, embryo development and implantation, uterine function and the endocrine system choreographing the reproductive process and results in infertility or spontaneous pregnancy loss. Current treatments are laden with menopausal-like side effects and many cause cessation or chemical alteration of the reproductive cycle, neither of which is conducive to achieving a pregnancy. However, despite the prevalence, physical and psychological tolls and health care costs, a cure for endometriosis has not yet been found. We hypothesize that endometriosis causes infertility via multifaceted mechanisms that are intricately interwoven thereby contributing to our lack of understanding of this disease process. Identifying and understanding the cellular and molecular mechanisms responsible for endometriosis-associated infertility might help unravel the confounding multiplicities of infertility and provide insights into novel therapeutic approaches and potentially curative treatments for endometriosis.

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Section: Impact On the Ovarymentioning

confidence: 99%

Cellular and molecular basis for endometriosis-associated infertility

2012

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“…The molecule has an external domain consisting of two regions exhibiting the features of the immunoglobulin superfamily [ 1 - 3 ]. CD147 is widely expressed in both hematopoietic and non-hematopoietic cells and tissues [ 4 - 7 ]. However, the molecule is strongly expressed on various cancer cells, thymocytes and activated T lymphocytes [ 3 , 6 , 8 - 12 ].…”

Section: Introductionmentioning

confidence: 99%

Generation of functional scFv intrabody to abate the expression of CD147 surface molecule of 293A cells

et al. 2008

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Background: Expression of intracellular antibodies (intrabodies) has become a broadly applicable technology for generation of phenotypic knockouts in vivo. The method uses surface depletion of cellular membrane proteins to examine their biological function. In this study, we used this strategy to block the transport of cell surface molecule CD147 to the cell membrane. Phage display technology was introduced to generate the functional antibody fragment to CD147, and we subsequently constructed a CD147-specific scFv that was expressed intracellularly and retained in the endoplasmic reticulum by adenoviral gene transfer.

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“…Expression of basigin is upregulated in endometriotic lesions in women (Braundmeier et al 2006, Smedts et al 2006, Jin et al 2014 and also in baboons (Braundmeier et al 2010). Levels of expression were highest in lesions of baboons at early stages of the disease (1-3 months) and decreased in later stages of disease progression (9-15 months).…”

Section: (D) Basigin In Uterine Reproductive Diseasesmentioning

confidence: 96%

“…Chang and coworkers (Chang et al 2004) reported that basigin was expressed in the corpora lutea during early gestation (days 1-3) but subsequently disappeared thereafter in Kunming White outbred mice. Smedts andcolleagues (McDonnel Smedts andCurry 2005, Smedts et al 2006) carried out a more detailed analysis of expression patterns in the rat ovary during specific functional stages of follicular development, follicular rupture and corpus luteum formation. They reported that Bsg expression was present in developing follicles from 1 to 48 h after eCG stimulation in the theca and granulosa cells.…”

Section: Role In Female Reproduction (A) Basigin In the Ovarymentioning

confidence: 99%

“…In cycling rats, Bsg mRNA was localized to the theca cells of preovulatory follicles and newly forming corpora lutea in cycling rats. Expression of basigin was also assessed in human ovaries (Smedts et al 2006). Basigin mRNA and protein were detected in granulosa cells in follicles at all stages of development and in the corpora lutea.…”

Section: Role In Female Reproduction (A) Basigin In the Ovarymentioning

confidence: 99%

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The role of basigin in reproduction

Nowak

2020

Reproduction

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Basigin is a highly glycosylated transmembrane protein that was originally identified as a product of tumor cells. Basigin is a potent inducer of matrix metalloproteinases (MMPs) and angiogenic factors such as vascular endothelial growth factor (VEGF). Basigin is also a chaperone protein for specific metabolite transporters in the plasma cell membrane such as the monocarboxylate transporters and is an important regulator of cell metabolism. Studies in reproductive model systems have demonstrated that basigin is expressed in the testis, ovary, uterus and placenta and is necessary for normal fertility in both males and females. Overexpression of basigin is associated with reproductive diseases including uterine leiomyomas and endometriosis. This review presents an overview of the literature regarding the physiological role of basigin in reproductive tissues and the mechanistic pathways involved in its actions.

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Expression of an extracellular matrix metalloproteinase inducer (basigin) in the human ovary and ovarian endometriosis

Cited by 16 publications

References 45 publications

Cellular and molecular basis for endometriosis-associated infertility

Cellular and molecular basis for endometriosis-associated infertility

Generation of functional scFv intrabody to abate the expression of CD147 surface molecule of 293A cells

The role of basigin in reproduction

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