Expression of annexin II in conventional renal cell carcinoma is correlated with Fuhrman grade and clinical outcome

Zimmermann, Uwe; Woenckhaus, Christian; Pietschmann, Sophie; Junker, Heike; Maile, S.; Schultz, Kris Ann P.; Protzel, Chris; Giebel, J.

doi:10.1007/s00428-004-1103-4

Cited by 64 publications

(62 citation statements)

References 26 publications

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“…Some of the annexins have been well characterised while less is known about the biology of some of the other Figure 3 The mean intensity of expression of individual annexins in normal colon, primary colorectal cancer and lymph node metastasis. Zimmermann et al, 2004aZimmermann et al, , b, 2007Syed et al, 2007). However, the annexin profile has not previously been investigated in individual tumour types.…”

Section: Discussionmentioning

confidence: 99%

“…Annexin A2 shows increased expression in several type of cancer, including renal cell cancer (Zimmermann et al, 2004a), breast cancer (Sharma et al, 2006) and sarcomas (Gillette et al, 2004;Syed et al, 2007), and there are several possible mechanisms by which annexin A2 may be involved in tumour progression. Annexin A2 interacts with tissue-type plasminogen activator and disruption of this interaction resulted in decreased tumour cell invasion (Rand, 2000;Diaz et al, 2004;Sharma et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…Together, these studies suggest that dysregulation of annexin A1 loss is important in oesophageal tumour development and progression. Other types of cancer in which the expression of annexin A1 has been shown to be altered include pancreatic adenocarcinoma (Bai et al, 2004), where it was found to show increased expression in the majority of tumours, renal cell carcinoma (Zimmermann et al, 2007), prostate adenocarcinoma (Patton et al, 2005), breast cancer (Shen et al, 2006) and B-cell non-Hodgkin's lymphoma (Vishwanatha et al, 2004).…”

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confidence: 99%

“…Overexpression of annexin A2 has been found in renal cell cancer, where it is associated with tumour stage (Zimmermann et al, 2004a), invasive breast cancer (Sharma et al, 2006) and sarcomas, including both soft tissue sarcomas (Syed et al, 2007) and osteosarcomas (Gillette et al, 2004). There is increased expression of annexin A4 in renal clear cell carcinoma (Zimmermann et al, 2004b).…”

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confidence: 99%

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Characterisation and protein expression profiling of annexins in colorectal cancer

Carpenter²,

et al. 2007

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The annexins are family of calcium-regulated phospholipid-binding proteins with diverse roles in cell biology. Individual annexins have been implicated in tumour development and progression, and in this investigation a range of annexins have been studied in colorectal cancer. Annexins A1, A2, A4 and A11 were identified by comparative proteomic analysis to be overexpressed in colorectal cancer. Annexins A1, A2, A4 and A11 were further studied by immunohistochemistry with a colorectal cancer tissue microarray containing primary and metastatic colorectal cancer and also normal colon. There was significant increase in expression in annexins A1 (P ¼ 0.01), A2 (Po0.001), A4 (Po0.001) and A11 (Po0.001) in primary tumours compared with normal colon. There was increasing expression of annexins A2 (P ¼ 0.001), A4 (P ¼ 0.03) and A11 (P ¼ 0.006) with increasing tumour stage. An annexin expression profile was identified by k-means cluster analysis, and the annexin profile was associated with tumour stage (P ¼ 0.01) and also patient survival. Patients in annexin cluster group 1 (low annexin expression) had a better survival (log rank ¼ 5.33, P ¼ 0.02) than patients in cluster group 2 (high annexins A4 and A11 expression). In conclusion, this study has shown that individual annexins are present in colorectal cancer, specific annexins are overexpressed in colorectal cancer and the annexin expression profile is associated with survival.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Characterisation and protein expression profiling of annexins in colorectal cancer

Carpenter²,

et al. 2007

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“…Recently, an in vitro study of rat RCC showed an association between ANX2 overexpression and metastasis (Tanaka et al, 2004). In addition, another report showed that ANX2 expression correlated with higher nuclear grade of the tumour and poor clinical outcome, although the study included only 33 cases (Zimmermann et al, 2004). These findings imply that ANX2 may be involved in the metastatic process in RCC.…”

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confidence: 91%

Annexin II represents metastatic potential in clear-cell renal cell carcinoma

et al. 2009

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BACKGROUND: Annexin II (ANX2) is a multi-functional protein involved in cell proliferation and membrane physiology and is related to cancer progression. The purpose of this study was to assess ANX2 expression in clear-cell (cc) renal cell carcinoma (RCC). METHODS: The ANX2 expression in 18 primary ccRCCs was examined by real-time reverse transcriptase (RT) -PCR and western blot analyses. Furthermore, immunohistochemical study was performed using paraffin section of 154 primary ccRCCs and 24 metastases. The association between ANX2 expression and the clinicopathological factors and prognosis was analysed. RESULTS: The ANX2 was upregulated at both mRNA and protein levels in 14 of 18 primary ccRCCs. Immunohistochemical analysis showed that ANX2 was positive in 73 (47.4%) of 154 primary ccRCC and in 21 (87.5%) of 24 metastatic tumours. The ANX2 expression in the primary tumours showed significant associations with a higher stage, a higher nuclear grade. In patients without metastasis, the 5-year metastasis-free rate in patients with ANX2-positive tumour was significantly lower than that in those with ANX2-negative tumour (63.0% vs 90.1%; Po0.0001). Multivariate analysis showed that ANX2 expression is an independent predictor for metastasis. CONCLUSION: Our findings suggest that ANX2 expression might be a novel predictor of the metastatic potential of ccRCC.

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Annexin A2 (ANX A2): An emerging biomarker and potential therapeutic target for aggressive cancers

Sharma

2018

Intl Journal of Cancer

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ANX A2 is an important member of annexin family of proteins expressed on surface of endothelial cells (ECs), macrophages, mononuclear cells and various types of cancer cells. It exhibits high affinity binding for calcium (Ca ) and phospholipids. ANX A2 plays an important role in many biological processes such as endocytosis, exocytosis, autophagy, cell-cell communications and biochemical activation of plasminogen. On the cell surface ANX A2 organizes the assembly of plasminogen (PLG) and tissue plasminogen activator (tPA) for efficient conversion of PLG to plasmin, a serine protease. Proteolytic activity of plasmin is required for activation of inactive pro-metalloproteases (pro-MMPs) and latent growth factors for their biological actions. These activation steps are critical for degradation of extracellular matrix (ECM) and basement proteins (BM) for cancer cell invasion and metastasis. Increased expression of ANX A2 protein/gene has been correlated with invasion and metastasis in a variety of human cancers. Moreover, clinical studies have positively correlated ANX A2 protein expression with aggressive cancers and with resistance to anticancer drugs, shorter disease-free survival (DFS), and worse overall survival (OS). The mechanism(s) by which ANX A2 regulates cancer invasion and metastasis are beginning to emerge. Investigators used various technologies to target ANX A2 in preclinical model of human cancers and demonstrated exciting results. In this review article, we analyzed existing literature concurrent with our own findings and provided a critical overview of ANX A2-dependent mechanism(s) of cancer invasion and metastasis.

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Expression of annexin II in conventional renal cell carcinoma is correlated with Fuhrman grade and clinical outcome

Cited by 64 publications

References 26 publications

Characterisation and protein expression profiling of annexins in colorectal cancer

Characterisation and protein expression profiling of annexins in colorectal cancer

Annexin II represents metastatic potential in clear-cell renal cell carcinoma

Annexin A2 (ANX A2): An emerging biomarker and potential therapeutic target for aggressive cancers

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