Expression of antigens involved in the presentation of lipid antigens and induction of clonal anergy in the female reproductive tract

Sallinen, Kirsimarja; Veräjänkorva, Esko; Pöllänen, Pasi

doi:10.1016/s0165-0378(99)00061-3

Cited by 20 publications

(12 citation statements)

References 24 publications

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“…Interestingly, CD1d was expressed on trophoblasts, the fetal cells that invade the maternal tissue. CD1d expression has previously been reported in myeloid lineage cells, B cells, and activated T cells (28) as well as on intestinal and reproductive tract epithelia (35,36). Immunohistochemical staining demonstrated CD1d expression on both villous and extravillous trophoblasts [as judged by costaining of serial sections for the epidermal growth factor-like c-erbB-2, an extravillous trophoblast marker (30)], but not syncytiotrophoblast.…”

Section: Discussionmentioning

confidence: 70%

CD1d and invariant NKT cells at the human maternal–fetal interface

Boyson

Rybalov

Koopman

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

165

144

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Invariant CD1d-restricted natural killer T (iNKT) cells comprise a small, but significant, immunoregulatory T cell subset. Here, the presence of these cells and their CD1d ligand at the human maternal-fetal interface was investigated. Immunohistochemical staining of human decidua revealed the expression of CD1d on both villous and extravillous trophoblasts, the fetal cells that invade the maternal decidua. Decidual iNKT cells comprised 0.48% of the decidual CD3؉ T cell population, a frequency 10 times greater than that seen in peripheral blood. Interestingly, decidual CD4؉ iNKT cells exhibited a striking Th1-like bias (IFN-␥ production), whereas peripheral blood CD4؉ iNKT clones exhibited a Th2-like bias (IL-4 production). Moreover, compared to their peripheral blood counterparts, decidual iNKT clones were strongly polarized toward granulocyte͞macrophage colony-stimulating factor production. The demonstration of CD1d expression on fetal trophoblasts together with the differential pattern of cytokine expression by decidual iNKT cells suggests that maternal iNKT cell interactions with CD1d expressed on invading fetal cells may play an immunoregulatory role at the maternal-fetal interface.

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Section: Discussionmentioning

confidence: 70%

CD1d and invariant NKT cells at the human maternal–fetal interface

Boyson

Rybalov

Koopman

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

165

144

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“…110 CD1d has been shown to be expressed on dendritic cells, B cells, hepatocytes, intestinal epithelial cells, 111 trophoblast cell lines, 110 and mouse endometrial epithelial cells. 112 Cultured human uterine epithelial cells also express CD1d, suggesting they have the potential to present lipid antigens and interact with CD8 + or double-negative T cells.…”

Section: Antigen Presentation By Human Uterine Epithelial Cellsmentioning

confidence: 99%

Innate and adaptive immunity in the human female reproductive tract: influence of the menstrual cycle and menopause on the mucosal immune system in the uterus

Wira¹,

Fahey²,

Schaefer³

et al. 2008

Reproductive Medicine and Assisted Reproductive Techniques

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Synopsis Background• The mucosal surfaces of the female reproductive tract (FRT) defend it against pathogenic organisms.• The reproductive tract is an inductive as well as a reactive site for immune responses.• Immune protection must deal with sexually transmitted or opportunistic bacterial, fungal, and viral pathogens, while responding differently to allogeneic spermatozoa, and the immunologically distinct fetus.• The mucosal defense function combines innate (antigen non-specific) and adaptive (antigen-specific)

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“…We therefore sought to (i) characterize the expression of MHC II, CD40, CD80, CD86 and pIgR, and (ii) determine the effects of oestradiol treatment on the expression of these molecules by uterine and vaginal cells. Whereas the expression of MHC II by FRT tissues has been documented, the expression of co‐stimulatory molecules is less certain 11,13,14,51,52 . This may be partly because of the low sensitivity of procedures that rely on antibody staining, especially for detecting less stable molecules that are weakly expressed by some APC 53,54 .…”

Section: Discussionmentioning

confidence: 99%

Effect of oestradiol and pathogen‐associated molecular patterns on class II‐mediated antigen presentation and immunomodulatory molecule expression in the mouse female reproductive tract

et al. 2011

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SummaryCells of the female reproductive tract (FRT) can present antigen to naive and memory T cells. However, the effects of oestrogen, known to modulate immune responses, on antigen presentation in the FRT remain undefined. In the present study, DO11.10 T-cell antigen receptor transgenic mice specific for the class II MHC-restricted ovalbumin (OVA) 323-339 peptide were used to study the effects of oestradiol and pathogen-associated molecular patterns on antigen presentation in the FRT. We report here that oestradiol inhibited antigen presentation of OVA by uterine epithelial cells, uterine stromal cells and vaginal cells to OVA-specific memory T cells. When ovariectomized animals were treated with oestradiol for 1 or 3 days, antigen presentation was decreased by 20-80%. In contrast, incubation with PAMP increased antigen presentation by epithelial cells (Pam 3 Cys), stromal cells (peptidoglycan, Pam 3 Cys) and vaginal cells (Pam 3 Cys). In contrast, CpG inhibited both stromal and vaginal cell antigen presentation. Analysis of mRNA expression by reverse transcription PCR indicated that oestradiol inhibited CD40, CD80 and class II in the uterus and CD40, CD86 and class II in the vagina. Expression in isolated uterine and vaginal cells paralleled that seen in whole tissues. In contrast, oestradiol increased polymeric immunoglobulin receptor mRNA expression in the uterus and decreased it in the vagina. These results indicate that antigen-presenting cells in the uterus and vagina are responsive to oestradiol, which inhibits antigen presentation and co-stimulatory molecule expression. Further, these findings suggest that antigen-presenting cells in the uterus and vagina respond to selected Toll-like receptor agonists with altered antigen presentation.

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Expression of antigens involved in the presentation of lipid antigens and induction of clonal anergy in the female reproductive tract

Cited by 20 publications

References 24 publications

CD1d and invariant NKT cells at the human maternal–fetal interface

CD1d and invariant NKT cells at the human maternal–fetal interface

Innate and adaptive immunity in the human female reproductive tract: influence of the menstrual cycle and menopause on the mucosal immune system in the uterus

Effect of oestradiol and pathogen‐associated molecular patterns on class II‐mediated antigen presentation and immunomodulatory molecule expression in the mouse female reproductive tract

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