Expression of Aquaporin 1 in Bladder Uroepithelial Cell Carcinoma and its Relevance to Recurrence

Abstract

Objectives: To explore the expression of aquaporin 1 (AQP 1 ) in bladder uroepithelium cell carcinoma (BUCC) and its relevance to recurrence. Materials and Methods: Tissue samples from 45 BUCC patients who underwent total cystectomy or transurethral resection of bladder tumor (TURBT) and from 40 patients with non-bladder cancers who underwent special detection or treatments were collected. The level of expression of AQP 1 in BUCC tissues and normal bladder tissues was assessed by immunohistochemistry so as to analyze the relevance to pathological patterns and time of recurrence in BUCC patients. Results: The expression levels of AQP 1 normal bladder tissues and BUCC tissues were 2.175±0.693 and 3.689±0.701, respectively, and the difference was significant (t=9.99, P<0.0001). Marked increase was noted with BUCC histological grade and pathological stage (P<0.01). Moreover, the expression of AQP 1 was evidently higher in cancerous tissues with lymph node metastasis than in those without (P<0.01). With short-term recurrence, the positive cell expression rate of AQP 1 was higher in primary tissues, which increased obviously after recurrence. Additionally, the recurrent time of BUCC was negatively associated with the positive cell expression rate of AQP 1 and the difference between the expression of AQP 1 before and after recurrence (r=-0.843, F=39.302, P=0.000; r=-0.829, F=35.191, P=0.000). Conclusions: AQP 1 , which reflects the grade, stage, lymph node metastasis and recurrence of BUCC, has potential guiding significance in the diagnosis and treatment of bladder cancarcinoma.

Aquaporin‐1 expression in fluoro‐edenite‐induced mesothelioma effusions: An approach by cell‐block procedure

“…Namely, a statistically significant association of AQP‐1 high expression with increased survival was observed with a median OS of 12 months for patients with ≥50% AQP‐1 expression vs a median OS of only 7 months for patients with less than 50% AQP‐1 expression. The relationship between higher levels of AQP‐1 in MM and a better prognosis confirms the results of previous studies, but appears to be in conflict with data reported in other tumours, including breast cancer, melanoma, urothelial carcinoma and pharyngeal squamous cell carcinoma, in which increased levels of AQP1 are associated with a poorer prognosis . These data and the relatively few studies on MM require further validation.…”

Role of Aquaporin 1 Signalling in Cancer Development and Progression

“…AQP1 is over-expressed in multiple human cancers including that of biliary duct, bladder, brain, breast, cervix, colon, lung, nasopharynx and prostate [17,18,19,20,21,22,23,24,25,26]. In the case of colon cancer, Moon and colleagues showed expression of AQP1 in colonic adenoma, primary and secondary colon cancer, but not in normal colonic mucosa, suggesting a role of AQP1 in the early stage of colon cancer tumorigenesis [19].…”

AQP1 (aquaporin 1 (Colton blood group))

“…Marked increase expression levels of aquaporin-1 was noted with bladder urothelial carcinoma histological grade and pathological stage. The expression of aquaporin-1 was markedly higher in cancerous tissues with lymph node metastasis (Liu et al, 2015).…”