Expression of basement membrane laminin in oral squamous cell carcinomas

Reis, Sílvia Regina de Almeida; Souza, Leonardo Francisco Provedel de; Souza, Verônica Ferreira de; Silva, Lílian Dantas de Góes; Santos, Jean Nunes dos

doi:10.1016/s1808-8694(15)31173-3

Cited by 12 publications

(4 citation statements)

References 23 publications

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“…Both poorly differentiated tumours and well-differentiated tumours showed limited BM laminin expression, the same was true for tumour extent, an observation that suggests that disruption of BM laminin is an early process in tumour progression. The correlation of BM continuity with differentiation is in line with observations in bladder-, colorectal-, hepatocellular-, breast-, endometrial cancer and an earlier report on pancreatic cancer (Albrechtsen et al , 1981; Forster et al , 1984, 1986; Stenback et al 1985; Mollenhauer et al , 1987; Schapers et al , 1990; Grigioni et al , 1991; Lazaris et al , 2003; Souza et al , 2007). BM continuity has also been associated with stage in some tumours (Havenith et al , 1988; Schapers et al , 1990) and metastasis in others (Forster et al , 1984; Forster et al , 1986; Mielcarek-Kuchta et al , 2008).…”

Section: Discussionsupporting

confidence: 89%

Tumour basement membrane laminin expression predicts outcome following curative resection of pancreatic head cancer

et al. 2012

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Background:Although widely fragmented BMs have been associated with adverse outcome in several cancer types, comparatively little is known with respect to its effect on the prognosis of pancreatic cancer. The aim of the current study was therefore to determine the prognostic value of tumour basement membrane (BM) continuity in two anatomically closely related, however, prognostically different tumours, pancreatic head- and periampullary cancer.Methods:Tumour BM continuity was determined by immunohistochemical staining of its two major components, laminin and collagen type IV. Associations were made with recurrence free survival (RFS), cancer-specific survival (CSS), overall survival (OS) and conventional prognostic factors.Results:Fifty-nine and 61% of pancreatic head and periampullary tumours, respectively, showed limited BM laminin expression. Whereas 43% and 41% of pancreatic head and periampullary cancers, respectively, showed limited BM collagen type IV expression. Limited BM laminin was associated with poor outcome following curative resection of pancreatic head cancer (P=0.034, 0.013 and 0.017 for RFS, CSS and OS, respectively). Two and a half times as many patients with ⩾25% BM laminin were recurrence free and alive 5 years following resection compared with those with limited BM laminin. Although staining patterns of both BM components were weakly correlated with each other, BM collagen type IV expression was not significantly associated with outcome in either tumour type.Conclusion:Discontinuous BMs, determined by laminin expression, are associated with poor outcome following curative resection of pancreatic head cancer.

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Section: Discussionsupporting

confidence: 89%

Tumour basement membrane laminin expression predicts outcome following curative resection of pancreatic head cancer

et al. 2012

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“…The predominant presence of laminin‐332 in the tumor‐stromal interface of invasive OSSC suggests that this marker has an important role in the invasion and migration of dysplastic cells. In consonance with previous studies, it supports the hypothesis that the expression of laminin‐332 can be predictive of malignancy (de Almeida Reis et al., 2007; Silva et al., 2018). We found an expressive discontinuous staining in most of the laminin‐positive samples of OLP and OLL in the BM, suggesting that an altered epithelial BM can be involved in the pathogenesis of both OLP and OLL and their progression to OSCC.…”

Section: Introductionsupporting

confidence: 90%

“…It has an important function in adhesion of epithelia cells to the BM and structural support to the tissues. In oral potentially malignant disorders and oral cancers, the presence of laminin‐332 with membrane disruption has been associated with migration and attachment of cancer cells and suggested as an important marker of malignancy (de Almeida Reis, Provedel de Souza, Ferreira de Souza, de Goes Silva, & Dos Santos, 2007). The loss of laminin‐332 from the BM and its increase in the stromal area has been strongly associated with the process of malignant transformation (Silva, Freitas, Bautz, de Barros, & da Gama de Souza, 2018; Zargaran, Eshghyar, Vaziri, & Mortazavi, 2011).…”

Section: Introductionmentioning

confidence: 99%

Laminin‐332 expression in oral lichen planus: Preliminary results of a cross‐sectional study

et al. 2020

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“…Collagenous and elastic fibers, the main components of the extracellular matrix (ECM), are distributed widely among the varying oral mucosa layers. While providing a protective screen for the cells, tissues and organs it supports, the ETM is also involved in cell proliferation, survival and apoptosis ( 1 , 2 ). Clinically, a number of oral mucosal diseases are associated with the remodeling of collagenous and elastic fibers ( 3 , 4 ).…”

Section: Introductionmentioning

confidence: 99%

MMP-1/2 and TIMP-1/2 expression levels, and the levels of collagenous and elastic fibers correlate with disease progression in a hamster model of tongue cancer

Fan

Jiang

et al. 2015

Oncology Letters

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In the present study, the presence of extracellular matrix components, including collagenous and elastic fibers, and the expression of their key regulating enzymes, were investigated in different stages of hamster tongue carcinoma development. Immunohistochemical and computer-assisted morphological analyses were performed to quantify the staining intensity and area (integral optical density) of matrix metalloproteinase (MMP)-1 and −2, tissue inhibitors of metalloproteinase (TIMP)-1 and −2, and the extent of elastic and collagenous fibers in histological sections. MMP-1, MMP-2, TIMP-1 and TIMP-2 expression levels gradually increased with tongue cancer progression, and were associated with disease pathology staging (r=0.705, 0.633, 0.759 and 0.751, respectively). By contrast, elastic fiber levels gradually decreased with cancer progression and were negatively correlated with disease staging (r=-0.881). The levels of collagenous fibers gradually increased with cancer progression and showed a positive correlation (r=0.619). In summary, the study demonstrated that MMP1/2 and TIMP1/2 expression levels, and collagenous and elastic fiber levels were significantly correlated with disease progression in a hamster model of tongue cancer.

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Expression of basement membrane laminin in oral squamous cell carcinomas

Abstract: Different expressions of laminin, a glycoprotein present in basement membranes were evident in oral cell carcinomas within different grades of histological malignancy.

Cited by 12 publications

References 23 publications

Tumour basement membrane laminin expression predicts outcome following curative resection of pancreatic head cancer

Tumour basement membrane laminin expression predicts outcome following curative resection of pancreatic head cancer

Laminin‐332 expression in oral lichen planus: Preliminary results of a cross‐sectional study

MMP-1/2 and TIMP-1/2 expression levels, and the levels of collagenous and elastic fibers correlate with disease progression in a hamster model of tongue cancer

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