Expression of bone markers and micro‐CT analysis of alveolar bone during orthodontic relapse

Abstract

Bone tissue reactions on a molecular level are similar during OTM and orthodontic relapse. These findings validate the importance of immediate retention following active OTM.

Effect of pharmacological agents on relapse following orthodontic tooth movement:

“…4 Further histologic studies, conducted predominantly on animal models, demonstrated that the pattern of tissue and molecular level responses immediately after withdrawal of orthodontic force were similar to those seen during active orthodontic tooth movement (OTM). [6][7][8] Continued activity of osteoclasts in the direction of relapse, osteoblasts in the direction opposite to that of relapse, gene expression of markers of alveolar bone and collagen remodeling were consistent with that observed during OTM, but in the opposite direction. [6][7][8] Underpinned by this similarity in physiological patterns occurring during OTM and OR, chemical preparations determined to decrease the rate of OTM by targeting the cascades involved in alveolar bone remodeling can potentially modulate OR.…”

“…[6][7][8] Continued activity of osteoclasts in the direction of relapse, osteoblasts in the direction opposite to that of relapse, gene expression of markers of alveolar bone and collagen remodeling were consistent with that observed during OTM, but in the opposite direction. [6][7][8] Underpinned by this similarity in physiological patterns occurring during OTM and OR, chemical preparations determined to decrease the rate of OTM by targeting the cascades involved in alveolar bone remodeling can potentially modulate OR. Evidence from animal and human studies indicated that commonly prescribed drugs, such as nonsteroidal antiinflammatory drugs, bisphosphonates, and statins, had an inhibitory effect on the rate of OTM.…”

“…Theoretically, any substance modulating the signaling pathways involved in periodontal tissue remodeling can affect tooth movement relapse. 4,7,8 Accordingly, it was observed in the current review process that substantial research on the effects of various biomi-metics, recombinant proteins and pharmacological substances on OR is being undertaken. However, contemplating the viability of translation of findings to human settings, the current review was restricted to studies investigating commonly prescribed medications.…”

Lithium enhances alveolar bone formation during orthodontic retention in rats

“…Consequently, effective retention is critical to the success of orthodontic treatments. An in vivo study in rats demonstrated that, in the absence of retention, within 1 day of removing an appliance, the average relapse rate for murine molars was 73%, and this rate increased continuously to 93% by 21 days after appliance removal . Relapse is an undesirable situation for both patients and clinicians.…”

Estudo in vitro da perfuração radicular por diferentes diâmetros de mini-implantes

“…Em Ortodontia, a Micro-CT tem sido empregada nos trabalhos em animais que pesquisam remodelação óssea (FRANZEN et al, 2014;KRAUS et al, 2014) e reabsorção radicular (KARADENIZ et al, 2013;PONDER et al, 2013) decorrentes da movimentação ortodôntica, estabilidade de mini-implante e resposta óssea ao seu redor (MASSEY et al, 2012;DRESCHER, 2011;WU et al, 2014), características estruturais tridimensionais de bráquetes (KANG et al, 2013), mensuração da espessura das corticais ósseas e disponibilidade de espaço para inserção de mini-implantes em peças anatômicas(LAURSEN; MELSEN; CATTANEO, 2013;WILMES et al, 2006), entre outras aplicações. A avaliação do contato/perfuração radicular por mini-implantes geralmente tem sido feita através de análise histológica (AHMED et al, 2012;ASSCHERICKX et al, 2005;BRISCENO et al, 2009;SHIN;KYUNG, 2008;DAO et al, 2009;KIM, 2011;LEE et al, 2010;MAINO et al, 2007;RENJEN et al, 2009) TASDEMIR, 2011;HWANG, 2011;KURODA et al, 2007;MCCABE;KAVANAGH, 2012), muitas vezes limitadas por ser tratar de imagens bidimensionais (ASSCHERICKX et al, 2008), e por tomografia computadorizada de feixe cônico (KURODA et al, 2007;SHIGEEDA, 2014;SHINOHARA et al, 2013;SON et al, 2014;WATANABE et al, 2013) (BARROS et al, 2011;FLORVAAG et al, 2010;HWANG, 2008;WILMES et al, 2008a;<...>…”