Expression of c‐<i>myc</i> and c‐<i>fos</i> oncogenes in different rat brain regions during postnatal development

Parma, Diana Lidia; Benasayag, Silvia J; Szijan, Irene

doi:10.1016/0736-5748(91)90023-f

Cited by 18 publications

(8 citation statements)

References 19 publications

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“…c-myc expression has been shown to increase in normal lymphocytes stimulated to divide by mitogen and growth factors and to decrease when the cells are stopped in GdG, (Lomo et al 1987), suggesting a correlation with proliferative activity. These results were confirmed in many normal (Parma et al 1991) and tumour cells (Harding et af. 1992).…”

Section: Discussionsupporting

confidence: 53%

Changes in oncogene expression in ascite tumour cells during ageing

et al. 1994

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The expression of two oncogenes, c-myc and c-fos, was studied in an ascitic tumour (ATPC+) at different times after implantation. The specific mRNA synthesis was analysed by Northern blot analysis. The presence of the oncogene proteins was shown by immunofluorescence using flow cytometry and referred to the distribution of the cells in the different cell phases. The results show that both oncogenes are expressed by ATPC+ tumour cells. c-myc is expressed 5, 8 and 12 days after implantation, although with a different intensity, and the protein is mainly present in S or S+G2 phase cells. The c-fos oncogene is expressed only 12 days after tumour implantation and the cells labelled with the specific antibody are mainly in G1 phase. We conclude that c-myc is principally correlated with proliferative activity, whereas c-fos is expressed by non-cycling cells.

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Section: Discussionsupporting

confidence: 53%

Changes in oncogene expression in ascite tumour cells during ageing

et al. 1994

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“…Even though the clonal expansion of increasing malignant tumor cells in nascent medulloblastomas results from the accumulation of genetic lesions, the failure of residual neuroectodermal cells to differentiate or to undergo apoptosis in the post‐natal brain could provide the cellular substrate for these genetic lesions. Given the central role that c‐ myc is thought to play in regulating cell proliferation, cell differentiation and cell death in the developing cerebellum (Hirvonen et al, 1990; Parma et al, 1991; Ruppert et al, 1986), one may hypothesize that c‐ myc plays a contributory role in the molecular pathogenesis of medulloblastoma. Indeed, c‐ myc gene amplification is a common finding in cell lines derived from medulloblastomas (Batra et al, 1994; Bruggers et al, 1998; Pietsch et al, 1994; Selvanayagam et al, 1988).…”

Section: Discussionmentioning

confidence: 99%

C-MYC expression in medulloblastoma and its prognostic value

Herms¹,

et al. 2000

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“…Several studies have indicated that the expression of IEGs during the early postnatal period undergoes a significant change and does so in a region‐specific manner. In the cerebral cortex and cerebellum of neonatal rats, constitutive levels of c‐ fos mRNA undergo a sharp decline during the first 10 days of postnatal development (Parma et al, 1991). However, in the hypothalamus, levels of c‐ fos mRNA remain high during this period and decrease only at a later age.…”

Section: Discussionmentioning

confidence: 99%

Induction of c-Fos-like and FosB-like immunoreactivity reveals forebrain neuronal populations involved differentially in pup-mediated maternal behavior in juvenile and adult rats

Kalinichev¹,

Rosenblatt²,

Nakabeppu³

et al. 2000

J. Comp. Neurol.

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Juvenile rats can exhibit maternal behavior after being exposed continuously to rat pups, a process called sensitization. Maternal behavior in juveniles is robust and is similar to adult maternal behavior (Mayer and Rosenblatt [1979] Dev. Psychobiol. 12:407–424; Gray and Chesley [684] J. Comp. Psychol. 98:91–99). In this study, immunocytochemical detection of the protein products of two immediate‐early genes, c‐fos and fosB, was used as a tool to identify forebrain neuronal populations involved in the maternal behavior of 27‐day‐old juvenile rats compared with 60‐day‐old adults. To sensitize them, rats were exposed continuously to foster pups. Once they were maternal, they were isolated from pups overnight, reexposed to pups for 2 hours, and then killed. Nonmaternal control animals also were isolated overnight and were either reexposed to pups for 2 hours or kept isolated from pups before killing. The lateral habenula (LH) was the only area in which both maternal juveniles and maternal adults had more c‐Fos‐immunoreactive (‐Ir) neurons compared with controls. In maternal adults, the number of neurons that expressed c‐Fos and FosB immunoreactivity increased in the medial preoptic area (MPO) and the ventral bed nucleus of the stria terminalis (BSTv), whereas the dorsal bed nucleus of the stria terminalis (BSTd) and the medial and cortical nuclei of the amygdala (MEA and COA, respectively) had increases only in the number of neurons that expressed c‐Fos immunoreactivity. In contrast, juveniles, whether or not they were maternal, had the same number of c‐Fos‐IR and FosB‐Ir neurons in all these areas. The adult‐like increase in the number of c‐Fos‐Ir neurons found in maternal juveniles suggests that the juvenile LH participates in the neural circuit that supports maternal behavior in an adult‐like manner. The lack of c‐fos or fosB induction in the MPO, BSTv, BSTd, COA, or MEA of maternal juveniles compared with maternal adults may reflect the immaturity of these brain regions in juvenile rats. Exactly what this immaturity consists of and when the responses of these regions become adult‐like remain to be determined. J. Comp. Neurol. 416:45–78, 2000. © 2000 Wiley‐Liss, Inc.

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Expression of c‐myc and c‐fos oncogenes in different rat brain regions during postnatal development

Cited by 18 publications

References 19 publications

Changes in oncogene expression in ascite tumour cells during ageing

Changes in oncogene expression in ascite tumour cells during ageing

C-MYC expression in medulloblastoma and its prognostic value

Induction of c-Fos-like and FosB-like immunoreactivity reveals forebrain neuronal populations involved differentially in pup-mediated maternal behavior in juvenile and adult rats

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