Expression of CD44 and Cyclin D1 in Fine Needle Aspiration Cytology of Papillary Thyroid Carcinoma

Kim, Jung Yeon; Cho, Hyejae; Rhee, Byoung Doo; Kim, Hong-Yong

doi:10.1159/000326975

Cited by 25 publications

(23 citation statements)

References 22 publications

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“…Genes involved in signal transduction like Cbp/ p300-interacting transactivator (CITED1) or calcyclin (S100A6), the cell cycle regulators stratifin (SFN) and cyclin D1 (CCND1), the estrogen-responsive gene EBAG9, or CD44 antigen constitute other examples of genes in the large RFR set which were already indicated in previous PTC studies (see Table 2; refs. 24,[28][29][30][31][32][33][34][35]. On the other side, there was no overlap between our genes and genes proposed recently by Mazzanti et al (7) for differential diagnosis of PTC.…”

Section: Discussionmentioning

confidence: 76%

Gene Expression Profile of Papillary Thyroid Cancer: Sources of Variability and Diagnostic Implications

Jarząb

Wiench²,

Fujarewicz³

et al. 2005

Cancer Research

242

162

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Section: Discussionmentioning

confidence: 76%

Gene Expression Profile of Papillary Thyroid Cancer: Sources of Variability and Diagnostic Implications

Jarząb

Wiench²,

Fujarewicz³

et al. 2005

Cancer Research

242

162

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“…This gene has been reported to be highly expressed in hepatocellular carcinomas (42) and was found to differentiate follicular thyroid tumors from normal thyroid (17). Cyclin D1 (CCND1), a regulatory subunit of CDK4 or CDK6, has been found to be overexpressed in papillary thyroid carcinomas (43) and predicts lymph node metastases in papillary thyroid carcinoma (44).…”

Section: Discussionmentioning

confidence: 99%

Gene Expression Profiling of Differentiated Thyroid Neoplasms

Chevillard¹,

Ugolin²,

Vielh

et al. 2004

Clinical Cancer Research

120

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Purpose: The purpose of this research was to identify novel genes that can be targeted as diagnostic and clinical markers of differentiated thyroid tumors.Experimental Design: Gene expression analysis using microarray platform was performed on 6 pathologically normal thyroid samples and 12 primary follicular and papillary thyroid neoplasms. Microarrays containing probes for 5,760 human full-length cDNAs were used for hybridization with total RNA from normal and tumor thyroid samples labeled with Cy3-dUTP and Cy5-dUTP, respectively. Scanned array images were recorded, and data analysis was performed. Selected sets of differentially expressed genes were analyzed using quantitative real-time reverse transcription-PCR for verification.Results: We identified 155 genes that differentiate histologically normal thyroid tissues from benign and malignant thyroid neoplasms. Of these 75 genes were differentiated between follicular neoplasms (adenoma and carcinoma) and the follicular variant of papillary carcinoma. Purely follicular neoplasms (adenomas and carcinomas) shared many genetic profiles, and only 43 genes were distinctly different between these tumors. Hierarchical cluster analysis also differentiated conventional papillary carcinoma from its follicular variant and follicular tumors. The differentially expressed genes were composed of members of cell differentiation, adhesion, immune response, and proliferation associated pathways. Quantitative real-time reverse transcription-PCR analysis of selected genes corroborated the microarray expression results.Conclusions: Our study show the following: (1) differences in gene expression between tumor and nontumor bearing normal thyroid tissue can be identified, (2) a set of genes differentiate follicular neoplasm from follicular variant of papillary carcinoma, (3) follicular adenoma and carcinoma share many of the differentiated genes, and (4) gene expression differences identify conventional papillary carcinoma from the follicular variant.

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“…Whereas galectin-3 is an immunocytochemical marker for follicular epithelial cell-derived carcinomas, 23 CD44 is a useful marker for PTC. 24 This report indicates that an infarcted nodule in paraffin sections of a thyroidectomy specimen should prompt the histopathologist to look carefully at the periphery of the nodule for surviving cells, if any, and their detailed morphologic features, especially if there is a prior FNA cytology report of PTC or any other neoplasm. Immunohistochemical studies on paraffin sections of the infarcted nodule may also help to arrive at a correct diagnosis.…”

Section: Discussionmentioning

confidence: 95%