Expression of chickBarx-1 and its differential regulation by FGF-8 and BMP signaling in the maxillary primordia

Barlow, Amanda; Bogardi, Jean-Philippe; Ladher, Raj K.; Francis‐West, Philippa

doi:10.1002/(sici)1097-0177(199904)214:4<291::aid-aja2>3.0.co;2-e

Cited by 113 publications

(100 citation statements)

References 46 publications

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“…2A). Barx1 cDNAs have been recently isolated from mouse (28), human (29), and chicken (30). The novel clone shows 82-84% total identity with known Barx1 homologues.…”

Section: B Lane 4) These Results Suggested That Carg Box Is the Crmentioning

confidence: 99%

Transcriptional Activation of β-Tropomyosin Mediated by Serum Response Factor and a Novel Barx Homologue, Barx1b, in Smooth Muscle Cells

Nakamura

Nishida

Mori

et al. 2001

Journal of Biological Chemistry

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Tropomyosin (TM) is a regulatory protein of actomyosin system. Muscle type-specific expression of TM isoforms is generated from different genes and by alternative splicing. ␤-TM isoforms in chicken skeletal and smooth muscles are encoded by a single gene and transcribed from the same promoter. We previously reported a smooth muscle cell (SMC) phenotype-dependent change in ␤-TM expression (Kashiwada, K., Nishida, W., Hayashi, K., Ozawa, K., Yamanaka, Y., Saga, H., Yamashita, T., Tohyama, M., Shimada, S., Sato, K., and Sobue, K.

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“…2A). Barx1 cDNAs have been recently isolated from mouse (28), human (29), and chicken (30). The novel clone shows 82-84% total identity with known Barx1 homologues.…”

Section: B Lane 4) These Results Suggested That Carg Box Is the Crmentioning

confidence: 99%

Transcriptional Activation of β-Tropomyosin Mediated by Serum Response Factor and a Novel Barx Homologue, Barx1b, in Smooth Muscle Cells

Nakamura

Nishida

Mori

et al. 2001

Journal of Biological Chemistry

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“…Some of the more characterized genes in the chicken embryo include AP2a, MSX1, MSX2, DLX5, TBX2, TBX3 (Brown et al, 1993;Shen et al, 1997;Gibson-Brown et al, 1998;Barlow et al, 1999;Ashique et al, 2002a;Szabo-Rogers et al, 2008. Our recent expression profile study has also identified many genes differentially expressed in the frontonasal mass and one of the most abundant was the T-box transcription factor, TBX22 (Buchtová et al, 2009).…”

Section: Introductionmentioning

confidence: 85%

The function and regulation of TBX22 in avian frontonasal morphogenesis

Higashihori¹,

Buchtová²,

Richman³

2010

Developmental Dynamics

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The frontonasal mass gives rise to the facial midline and fuses with the maxillary prominence to form the upper lip. Here we focus on the regulation and function of TBX22, a repressor dynamically expressed in the frontonasal mass. Both FGF and Noggin (a BMP antagonist) strongly induce gTBX22, however, each has opposite effects on morphogenesis -Noggin inhibits whereas FGF stimulates growth. To determine whether TBX22 mediates these effects, we used retroviruses to locally increase expression levels. RCAS::hTBX22 decreased proliferation, reduced expression of MSX2 and DLX5 and caused cleft lip. Decreased levels of endogenous gTBX22 were also observed but were not the primary cause of the phenotype as determined in rescue experiments. Our data suggest that genetic or environmental insults such as those affecting the BMP pathway could lead to a gain-of-function of TBX22 and predispose an individual to cleft lip. Developmental Dynamics 239:458-473,

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“…In the developing face, complimentary expression of Msx1 and Barx1 in the mandibular mesenchyme specifies patterning events including tooth formation [82,83]. Also, the overlapping expression of Msx and Dlx genes together with the evidence that members of the two families form heterodimers in vitro reveals a putative mechanism for controlling facial patterning events in vivo [55,84].…”

Section: Regulation Of Msx1 and Msx2 Expression And Facial Patterningmentioning

confidence: 99%

Msx homeobox gene family and craniofacial development

2003

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Vertebrate Msx genes are unlinked, homeobox-containing genes that bear homology to the Drosophila muscle segment homeobox gene. These genes are expressed at multiple sites of tissue-tissue interactions during vertebrate embryonic development. Inductive interactions mediated by the Msx genes are essential for normal craniofacial, limb and ectodermal organ morphogenesis, and are also essential to survival in mice, as manifested by the phenotypic abnormalities shown in knockout mice and in humans. This review summarizes studies on the expression, regulation, and functional analysis of Msx genes that bear relevance to craniofacial development in humans and mice.

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Expression of chickBarx-1 and its differential regulation by FGF-8 and BMP signaling in the maxillary primordia

Cited by 113 publications

References 46 publications

Transcriptional Activation of β-Tropomyosin Mediated by Serum Response Factor and a Novel Barx Homologue, Barx1b, in Smooth Muscle Cells

Transcriptional Activation of β-Tropomyosin Mediated by Serum Response Factor and a Novel Barx Homologue, Barx1b, in Smooth Muscle Cells

The function and regulation of TBX22 in avian frontonasal morphogenesis

Msx homeobox gene family and craniofacial development

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